Dietary choline metabolite TMAO impairs cognitive function and induces hippocampal synaptic plasticity declining through the mTOR/P70S6K/4EBP1 pathway
Abstract
-methyl-aspartate receptor (NMDAR), was examined by western blotting and immunohistochemical (IHC). The results showed that TMAO treatment contributes to neuron loss, synapse ultrastructure alteration, and synaptic plasticity impairments. In mechanism, the mammalian target of rapamycin (mTOR) regulates synaptic function, and the activation of the mTOR signaling pathway was observed in TMAO groups. In conclusion, this study confirmed that the choline metabolite TMAO can induce hippocampal-dependent learning and memory ability impairment with synaptic plasticity deficits by activating the mTOR signaling pathway. The effects of choline metabolites on cognitive function may provide a theoretical basis for establishing the daily reference intakes (DRIs) of choline.
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In the brain, TMAO is detrimental to neuronal physiology as it induces neuronal senescence, oxidative stress, and alters synaptic plasticity.
“In the brain, TMAO is detrimental to neuronal physiology as it induces neuronal senescence, oxidative stress, and alters synaptic plasticity.”
From Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases (2024) · cites this paper as [670]
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Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk
Tang, W. H. W., Wang, Z., Levison, B. S., Koeth, R. A., Britt, E. B., Fu, X., Wu, Y., & Hazen, S. L. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1109400 · Cited by 3,402 · see citing works
Viewpoints: how the hippocampus contributes to memory, navigation and cognition
Lisman, J., Buzsáki, G., Eichenbaum, H., Nadel, L., Ranganath, C., & Redish, A. D. (2017) · Nature Neuroscience · doi:10.1038/nn.4661 · Cited by 851 · see citing works
Trimethylamine‐<i>N</i>‐oxide promotes brain aging and cognitive impairment in mice
Li, D., Ke, Y., Zhan, R., Liu, C., Zhao, M., Zeng, A., Shi, X., Ji, L., Cheng, S., Pan, B., et al. (2018) · Aging Cell · doi:10.1111/acel.12768 · Cited by 304 · see citing works
Ma, T., Hoeffer, C. A., Capetillo-Zarate, E., Yu, F., Wong, H., Lin, M. T., Tampellini, D., Klann, E., Blitzer, R. D., & Gouras, G. K. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012845 · Cited by 262 · see citing works
Alzheimer’s disease and gut microbiota: does trimethylamine N-oxide (TMAO) play a role?
Arrona Cardoza, P., Spillane, M. B., & Morales Marroquin, E. (2022) · Nutrition Reviews · doi:10.1093/nutrit/nuab022 · Cited by 53 · see citing works
Quan, L., Yi, J., Zhao, Y., Zhang, F., Shi, X.-T., Feng, Z., & Miller, H. L. (2020) · NeuroToxicology · doi:10.1016/j.neuro.2019.10.012 · Cited by 44 · see citing works
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Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases
Loh, J. S., Mak, W. Q., Tan, L. K. S., Ng, C. X., Chan, H. H., Yeow, S. H., Foo, J. B., Ong, Y. S., How, C. W., & Khaw, K. Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01743-1 · Cited by 1,193 · see citing works
Zhao, Q., Chen, J., Wu, M., Yin, X., Jiang, Q., Gao, H., & Zheng, H. (2023) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2023.110638 · Cited by 49 · see citing works
- Authors
- Zhou, S., Liu, J., Sun, Y., Xu, P., Liu, J. L., Sun, S., Zhu, B., & Wu, H.
- Affiliations
- Nanjing University of Chinese Medicine (CN)
- Corresponding author
- Zhu, Boran
- Wu, Haoxin
- Venue
- Food & Function
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2023
- Volume
- 14
- Issue
- 6
- Pages
- 2881-2895
- ISSN
- 2042-6496 (ISSN-L)
- 2042-650X
- OpenAlex
- W4321456254
- Cited by
- 34
- References
- 6
- Citations by year
- 2026: 7 · 2025: 16 · 2024: 9 · 2023: 2
- FWCI
- 4.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Food & Function (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Graduate Research and Innovation Projects of Jiangsu Province (KYCX22_1886)
- National Natural Science Foundation of China (82074292)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- trimethylamine N-oxide, choline metabolites, cognitive impairment, hippocampus, synaptic plasticity, mTOR signaling, p70S6K, 4E-BP1, NMDA receptor, learning and memory, synaptic ultrastructure, neuronal loss, choline intake
- MeSH terms
- Choline, Cognition, Diet, Hippocampus, Humans, Methylamines, Neuronal Plasticity, Neurodegenerative Diseases, Ribosomal Protein S6 Kinases, 70-kDa, TOR Serine-Threonine Kinases
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