Cited by 53Gut microbiota and healthDementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Alzheimer’s disease and gut microbiota: does trimethylamine N-oxide (TMAO) play a role?

Arrona Cardoza, Pablo, Spillane, Micheil B, Morales Marroquin, Elisa·2022·Nutrition Reviews

Abstract

Alzheimer's disease (AD) is a neurodegenerative disease that affects memory and cognitive function. Clinical evidence has put into question our current understanding of AD development, propelling researchers to look into further avenues. Gut microbiota has emerged as a potential player in AD pathophysiology. Lifestyle factors, such as diet, can have negative effects on the gut microbiota and thus host health. A Western-type diet has been highlighted as a risk factor for both gut microbiota alteration as well as AD development. The gut-derived trimethylamine N-oxide (TMAO) has been previously implied in the development of cardiovascular diseases with recent evidence suggesting a plausible role of TMAO in AD development. Therefore, the main goal of the present review is to provide the reader with potential mechanisms of action through which consumption of a Western-type diet could increase AD risk, by acting through microbiota-produced TMAO. Although a link between TMAO and AD is far from definitive, this review will serve as a call for research into this new area of research.

Integrity signals

Registry

Crossref · 10.1093/nutrit/nuab022

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190 of 190 references verified0 citation errors · 0 not checkable

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Authors
Arrona Cardoza, P., Spillane, M. B., & Morales Marroquin, E.
Affiliations
  • Tecnológico de Monterrey, School of Medicine and Health Science, Monterrey, Nuevo Leon, Mexico
  • H.C. Drew School of Health and Human Performance, McNeese State University, Lake Charles, Louisiana, USA
  • School of Public Health, University of Texas Health Science Center at Houston, Houston, Texas, USA
Venue
Nutrition Reviews
Published
2021-05-03
Volume
80
Issue
2
Pages
271-281
ISSN
  • 0029-6643 (ISSN-L)
  • 1753-4887
OpenAlex
W3157088902
Cited by
53
References
192
Citations by year
2026: 7 · 2025: 11 · 2024: 13 · 2023: 8 · 2022: 12 · 2021: 2
FWCI
0.92
Type
journal article
Language
en
Open access
closed
Locations
  • Nutrition Reviews (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Keywords
Alzheimer's disease, gut microbiota, trimethylamine N-oxide, Western diet, neurodegeneration, gut-brain axis, dietary risk factors, cardiovascular risk
MeSH terms
Gastrointestinal Microbiome, Alzheimer Disease, Humans, Methylamines, Neurodegenerative Diseases

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