Cited by 49Gut microbiota and healthNeuroinflammation and Neurodegeneration MechanismsGastrointestinal motility and disorders

Microbiota from healthy mice alleviates cognitive decline via reshaping the gut-brain metabolic axis in diabetic mice

Zhao, Qihui, Chen, Junli, Wu, Mengjun, Yin, Xiaoli, Jiang, Qiaoying, Gao, Hongchang, Zheng, Hong·2023·Chemico-Biological Interactions

Abstract

Diabetic cognitive decline has been associated with the gut microbial disorders, but its potential gut-brain axis mechanisms remain unclear. Herein we transplanted the gut microbiota from healthy mice into type 1 diabetic (T1D) mice and then investigated the effect of fecal microbiota transplantation (FMT) on cognitive function and the gut-brain metabolic axis. The results demonstrate that FMT from healthy mice effectively improved the learning and memory abilities in T1D mice, and significantly reduced neuroinflammation and neuron injury in the cortex and hippocampus. Moreover, FMT partly reversed the gut microbiota and gut-brain metabolic disorders, particularly glutamate metabolism. In vitro study, we found that glutamate notably decreased microglia activation and the expression levels of proinflammatory factor. Hence, our study suggests that glutamate serves as a key signal metabolite connecting the gut to brain and affects cognitive functions.

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Crossref · 10.1016/j.cbi.2023.110638

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Authors
Zhao, Q., Chen, J., Wu, M., Yin, X., Jiang, Q., Gao, H., & Zheng, H.
Affiliations
Wenzhou Medical University (CN)
Corresponding author
  • Gao, Hongchang
  • Zheng, Hong
Venue
Chemico-Biological Interactions
Publisher
Elsevier BV
Published
2023-09
Volume
382
Pages
110638
ISSN
0009-2797 (ISSN-L)
OpenAlex
W4384699719
Cited by
49
References
68
Citations by year
2026: 7 · 2025: 7 · 2024: 7 · 2023: 28
FWCI
4.36
Type
journal article
Language
en
Open access
closed
Locations
  • Chemico-Biological Interactions (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Natural Science Foundation of China (22074106)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords
gut microbiota, fecal microbiota transplantation, type 1 diabetes, gut-brain axis, glutamate metabolism, neuroinflammation, microglial activation, learning and memory, hippocampus, cortex, metabolite signaling
MeSH terms
Brain-Gut Axis, Animals, Brain, Diabetes Mellitus, Experimental, Diabetes Mellitus, Type 1, Mice, Cognitive Dysfunction, Microbiota

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