Microbiota from healthy mice alleviates cognitive decline via reshaping the gut-brain metabolic axis in diabetic mice
Abstract
Diabetic cognitive decline has been associated with the gut microbial disorders, but its potential gut-brain axis mechanisms remain unclear. Herein we transplanted the gut microbiota from healthy mice into type 1 diabetic (T1D) mice and then investigated the effect of fecal microbiota transplantation (FMT) on cognitive function and the gut-brain metabolic axis. The results demonstrate that FMT from healthy mice effectively improved the learning and memory abilities in T1D mice, and significantly reduced neuroinflammation and neuron injury in the cortex and hippocampus. Moreover, FMT partly reversed the gut microbiota and gut-brain metabolic disorders, particularly glutamate metabolism. In vitro study, we found that glutamate notably decreased microglia activation and the expression levels of proinflammatory factor. Hence, our study suggests that glutamate serves as a key signal metabolite connecting the gut to brain and affects cognitive functions.
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Gut microbiota manipulation is linked to alterations in astrocytic proliferation and functions.
“Gut microbiota manipulation has also been linked to alterations in astrocytic proliferation and functions.253–256”
From Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases (2024) · cites this paper as [256]
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dos Santos, L. S., Recktenwald, R. D. R., Goldemberg, E. B., Malheiros, R. T., Sarmento, S. M. D. M., Schreiner, G. E., Schmitt, E. G., Brites, G. E., Rodrigues, A. C. D. O., Maders, L. T., et al. (2023) · doi:10.22533/at.ed.90623270913
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Lana, K. M. D. S., Farias, L. C., Chaves, L. S., Soares, K. M., Alvernaz, C. C. D., & Valadão, A. F. (2023) · doi:10.22533/at.ed.9062327095
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Gut-brain axis under attack: Links between diabetes, environmental toxicants, and neurodegeneration
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Self-citation
- Authors
- Zhao, Q., Chen, J., Wu, M., Yin, X., Jiang, Q., Gao, H., & Zheng, H.
- Affiliations
- Wenzhou Medical University (CN)
- Corresponding author
- Gao, Hongchang
- Zheng, Hong
- Venue
- Chemico-Biological Interactions
- Publisher
- Elsevier BV
- Published
- 2023-09
- Volume
- 382
- Pages
- 110638
- ISSN
- 0009-2797 (ISSN-L)
- OpenAlex
- W4384699719
- Cited by
- 49
- References
- 68
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 7 · 2023: 28
- FWCI
- 4.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Chemico-Biological Interactions (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (22074106)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- gut microbiota, fecal microbiota transplantation, type 1 diabetes, gut-brain axis, glutamate metabolism, neuroinflammation, microglial activation, learning and memory, hippocampus, cortex, metabolite signaling
- MeSH terms
- Brain-Gut Axis, Animals, Brain, Diabetes Mellitus, Experimental, Diabetes Mellitus, Type 1, Mice, Cognitive Dysfunction, Microbiota
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