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GSH/pH dual response drug delivery system for photothermal enhanced gene-immunotherapy
Abstract
GSH/pH dual-responsive nanoparticles was used for gene-photothermal synergistic therapy to cause cell immunogenic death and induce anti-tumor immune response.
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“Because activated fragments are often neutral to mildly negative, diffusion gains can outpace cellular entry, which encourages coupling shrinkage with a second lever such as latent cation exposure or ligand unmasking so that transport is not achieved at the expense of uptake [22, 24].”
From Overcoming tumor microenvironment barriers: transformable and bioinspired nanomedicine strategies for deep tumor penetration (2026) · cites this paper as [24]
In the citing paper
“When shrinkers are combined with prior microenvironment priming, for example brief courses that lower IFP or soften ECM, the same activated size window, about 20–50 nm, tends to produce more uniform coverage than without priming.”
From Overcoming tumor microenvironment barriers: transformable and bioinspired nanomedicine strategies for deep tumor penetration (2026) · cites this paper as [24]
In the citing paper
“In addition, when the activated entities approach the ultrasmall range, concentration gradients can drive partial back-diffusion toward vessels, and systemic elimination can accelerate once fragments re-enter circulation, collectively increasing the risk of intratumoral washout.”
From Overcoming tumor microenvironment barriers: transformable and bioinspired nanomedicine strategies for deep tumor penetration (2026) · cites this paper as [24]
In the citing paper
“Dual pH/GSH micelles combine charge reversal with disulfide cleavage to co-deliver siPD-L1 and indocyanine green, aligning photothermal guidance with checkpoint silencing [24].”
From Overcoming tumor microenvironment barriers: transformable and bioinspired nanomedicine strategies for deep tumor penetration (2026) · cites this paper as [24]
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Cited by
Sorted by citations
Sheng, J., Yuan, W., Zhang, M., Chen, Z., Qi, Y., Zhao, Y., & Zhang, S. (2026) · Journal of Nanobiotechnology · doi:10.1186/s12951-026-04028-7 · Cited by 35
Metadata
- Authors
- Ma, T., Li, W., Ye, J., Huang, C., Li, Y., Qiu, H., & Yin, S.
- Venue
- Nanoscale
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2023
- Volume
- 15
- Issue
- 42
- Pages
- 16947-16958
- ISSN
- 2040-3364
- 2040-3372
- Cited by
- 21
- References
- 0
- Language
- en
- Funders
- Natural Science Foundation of Zhejiang Province (LY23E030011, LZ23B040001)
- Zhejiang Provincial Ten Thousand Plan for Young Top Talents (2019R52040)
- National Natural Science Foundation of China (21971049, 51903070)
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Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: GSH/pH dual response drug delivery system for photothermal enhanced gene-immunotherapy. https://app.cochat.ai/papers/10.1039/d3nr03881e
- The paper
- Ma, T., Li, W., Ye, J., Huang, C., Li, Y., Qiu, H., & Yin, S. (2023). GSH/pH dual response drug delivery system for photothermal enhanced gene-immunotherapy. Nanoscale. https://doi.org/10.1039/d3nr03881e
