Knocking down barriers: advances in siRNA delivery

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Recent advances with liposomes as pharmaceutical carriers

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Role for a bidentate ribonuclease in the initiation step of RNA interference

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Factors affecting the clearance and biodistribution of polymeric nanoparticles

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Toxicity of cationic lipids and cationic polymers in gene delivery

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Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs

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A microRNA in a Multiple-Turnover RNAi Enzyme Complex

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Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways

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RNAi-mediated gene silencing in non-human primates

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Exploring polyethylenimine‐mediated DNA transfection and the proton sponge hypothesis

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Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA

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Sequence-specific potent induction of IFN-α by short interfering RNA in plasmacytoid dendritic cells through TLR7

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A combinatorial library of lipid-like materials for delivery of RNAi therapeutics

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Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs

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Distinct endocytic pathways regulate TGF-β receptor signalling and turnover

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RNA interference targeting Fas protects mice from fulminant hepatitis

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RNAi therapeutics: a potential new class of pharmaceutical drugs

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RNA interference in adult mice

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Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors

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Cell type–specific delivery of siRNAs with aptamer-siRNA chimeras

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Polyethylenimine-based non-viral gene delivery systems

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Mechanisms and optimization of in vivo delivery of lipophilic siRNAs

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Passenger-Strand Cleavage Facilitates Assembly of siRNA into Ago2-Containing RNAi Enzyme Complexes

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Sequence- and target-independent angiogenesis suppression by siRNA via TLR3

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Cationic liposome-mediated RNA transfection.

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Impact of tumor-specific targeting on the biodistribution and efficacy of siRNA nanoparticles measured by multimodality in vivo imaging

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Position-specific chemical modification of siRNAs reduces “off-target” transcript silencing

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Argonaute2 Cleaves the Anti-Guide Strand of siRNA during RISC Activation

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Inhibition of respiratory viruses by nasally administered siRNA

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RNAi-mediated gene-targeting through systemic application of polyethylenimine (PEI)-complexed siRNA in vivo

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Dynamic PolyConjugates for targeted in vivo delivery of siRNA to hepatocytes

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Design and gene delivery activity of modified polyethylenimines

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Lipid-based Nanoparticles for Nucleic Acid Delivery

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Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates

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Resolution of liver cirrhosis using vitamin A–coupled liposomes to deliver siRNA against a collagen-specific chaperone

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Insights into the kinetics of siRNA-mediated gene silencing from live-cell and live-animal bioluminescent imaging

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Polymers for gene delivery across length scales

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Design of Noninflammatory Synthetic siRNA Mediating Potent Gene Silencing in Vivo

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Sequence-Specific Knockdown of EWS-FLI1 by Targeted, Nonviral Delivery of Small Interfering RNA Inhibits Tumor Growth in a Murine Model of Metastatic Ewing's Sarcoma

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Molecular Basis for Target RNA Recognition and Cleavage by Human RISC

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Systemic Leukocyte-Directed siRNA Delivery Revealing Cyclin D1 as an Anti-Inflammatory Target

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Lactosylated Poly(ethylene glycol)-siRNA Conjugate through Acid-Labile β-Thiopropionate Linkage to Construct pH-Sensitive Polyion Complex Micelles Achieving Enhanced Gene Silencing in Hepatoma Cells

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Nonviral delivery of synthetic siRNAs in vivo

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Simple Modifications of Branched PEI Lead to Highly Efficient siRNA Carriers with Low Toxicity

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Using siRNA in prophylactic and therapeutic regimens against SARS coronavirus in Rhesus macaque

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Cell transfection in vitro and in vivo with nontoxic TAT peptide-liposome–DNA complexes

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Therapeutic silencing of mutant huntingtin with siRNA attenuates striatal and cortical neuropathology and behavioral deficits

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An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection

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Conjugate for efficient delivery of short interfering RNA (siRNA) into mammalian cells

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Administration in non-human primates of escalating intravenous doses of targeted nanoparticles containing ribonucleotide reductase subunit M2 siRNA

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A Small Interfering RNA Targeting Vascular Endothelial Growth Factor as Cancer Therapeutics

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A novel siRNA-lipoplex technology for RNA interference in the mouse vascular endothelium

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Full deacylation of polyethylenimine dramatically boosts its gene delivery efficiency and specificity to mouse lung

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Local and systemic delivery of VEGF siRNA using polyelectrolyte complex micelles for effective treatment of cancer

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Efficient delivery of small interfering RNA to bone-metastatic tumors by using atelocollagen in vivo

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Biochemical identification of Argonaute 2 as the sole protein required for RNA-induced silencing complex activity

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Biophysical and Structural Characterization of Polyethylenimine-Mediated siRNA Delivery in Vitro

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Influence of Polyethylene Glycol Chain Length on the Physicochemical and Biological Properties of Poly(ethylene imine)-graft-Poly(ethylene glycol) Block Copolymer/SiRNA Polyplexes

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Focal Adhesion Kinase Targeting UsingIn vivoShort Interfering RNA Delivery in Neutral Liposomes for Ovarian Carcinoma Therapy

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ISG15 inhibits Ebola VP40 VLP budding in an L-domain-dependent manner by blocking Nedd4 ligase activity

Okumura, A., Pitha, P. M., & Harty, R. N. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0710629105 · Cited by 286 · see citing works

A low molecular weight fraction of polyethylenimine (PEI) displays increased transfection efficiency of DNA and siRNA in fresh or lyophilized complexes

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A novel cationic lipid greatly enhances plasmid DNA delivery and expression in mouse lung.

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Antisense Drug Technology

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Gene transfer with modified polyethylenimines

Kichler, A. (2004) · The Journal of Gene Medicine · doi:10.1002/jgm.507 · Cited by 266 · see citing works

Postexposure Protection of Guinea Pigs against a Lethal Ebola Virus Challenge Is Conferred by RNA Interference

Geisbert, T. W., Hensley, L. E., Kagan, E., Yu, E. Z., Geisbert, J. B., Daddario-DiCaprio, K. M., Fritz, E. A., Jahrling, P. B., McClintock, K., Phelps, J. R., et al. (2006) · The Journal of Infectious Diseases · doi:10.1086/504267 · Cited by 254 · see citing works

Biodistribution of phosphodiester and phosphorothioate siRNA

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Evaluation of the safety, tolerability and pharmacokinetics of ALN-RSV01, a novel RNAi antiviral therapeutic directed against respiratory syncytial virus (RSV)

DeVincenzo, J. P., Cehelsky, J., Alvarez, R., Elbashir, S. M., Harborth, J., Toudjarska, I., Nechev, L. V., Murugaiah, V., VLIET, A., & Vaishnaw, A. K. (2008) · Antiviral Research · doi:10.1016/j.antiviral.2007.11.009 · Cited by 247 · see citing works

RNA Interference-Mediated Gene Silencing of Pleiotrophin Through Polyethylenimine-Complexed Small Interfering RNAs In Vivo Exerts Antitumoral Effects in Glioblastoma Xenografts

Grzelinski, M., Urban-Klein, B., Martens, T., Lamszus, K., Bakowsky, U., Höbel, S., Czubayko, F., & Aigner, A. M. (2006) · Human Gene Therapy · doi:10.1089/hum.2006.17.751 · Cited by 234 · see citing works

Short interfering RNA (siRNA) targeting the Lyn kinase induces apoptosis in primary, and drug-resistant, BCR-ABL1(+) leukemia cells

Ptasznik, A., Nakata, Y., Kalota, A., Emerson, S. G., & Gewirtz, A. M. (2004) · Nature Medicine · doi:10.1038/nm1127 · Cited by 229 · see citing works

Cationic lipids enhance siRNA-mediated interferon response in mice

Ma, Z., Li, J., He, F., Wilson, A. S., Pitt, B. R., & Li, S. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.03.041 · Cited by 225 · see citing works

Misinterpreting the Therapeutic Effects of Small Interfering RNA Caused by Immune Stimulation

Robbins, M., Judge, A. D., Ambegia, E., Choi, C., Yaworski, E., Palmer, L., McClintock, K., & MacLachlan, I. (2008) · Human Gene Therapy · doi:10.1089/hum.2008.131 · Cited by 222 · see citing works

Gene knockdown with intrathecal siRNA of NMDA receptor NR2B subunit reduces formalin-induced nociception in the rat

Tan, P.-H., Yang, L.-C., Hc, S., Lan, K.-C., & Cheng, J.-T. (2004) · Gene Therapy · doi:10.1038/sj.gt.3302376 · Cited by 222 · see citing works

Toxicogenomics of non-viral drug delivery systems for RNAi: Potential impact on siRNA-mediated gene silencing activity and specificity

Akhtar, S., & Benter, I. F. (2007) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.03.010 · Cited by 219 · see citing works

INTRAVENOUSLY ADMINISTERED SHORT INTERFERING RNA ACCUMULATES IN THE KIDNEY AND SELECTIVELY SUPPRESSES GENE FUNCTION IN RENAL PROXIMAL TUBULES

van de Water, F. M., Boerman, O. C., Wouterse, A. C., Peters, J. G. P., Rüssel, F. G. M., & Masereeuw, R. (2006) · Drug Metabolism and Disposition · doi:10.1124/dmd.106.009555 · Cited by 217 · see citing works

A Single siRNA Suppresses Fatal Encephalitis Induced by Two Different Flaviviruses

Kumar, P., Lee, S. K., Shankar, P., & Manjunath, N. (2006) · PLoS Medicine · doi:10.1371/journal.pmed.0030096 · Cited by 180 · see citing works

Impact of tumor‐specific targeting and dosing schedule on tumor growth inhibition after intravenous administration of siRNA‐containing nanoparticles

Bartlett, D. W., & Davis, M. E. (2007) · Biotechnology and Bioengineering · doi:10.1002/bit.21668 · Cited by 164 · see citing works

Antisense Oligonucleotide Directed to Human Apolipoprotein B-100 Reduces Lipoprotein(a) Levels and Oxidized Phospholipids on Human Apolipoprotein B-100 Particles in Lipoprotein(a) Transgenic Mice

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Fusogenic peptides enhance endosomal escape improving siRNA-induced silencing of oncogenes

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Effective RNAi-mediated gene silencing without interruption of the endogenous microRNA pathway

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Ocular delivery of nucleic acids: antisense oligonucleotides, aptamers and siRNA

Fattal, E., & Bochot, A. (2006) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2006.07.020 · Cited by 145 · see citing works

Heme Oxygenase-1 Is an Anti-Inflammatory Host Factor that Promotes Murine Plasmodium Liver Infection

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Low‐pH‐sensitive poly(ethylene glycol) (PEG)‐stabilized plasmid nanolipoparticles: effects of PEG chain length, lipid composition and assembly conditions on gene delivery

Li, W., Huang, Z. R., MacKay, J. A., Grube, S., & Szoka, F. C. (2004) · The Journal of Gene Medicine · doi:10.1002/jgm.634 · Cited by 140 · see citing works

Transport of phosphorothioate oligonucleotides in kidney: Implications for molecular therapy

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