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Cited by 43Molecular Biology Techniques and ApplicationsMicrofluidic and Capillary Electrophoresis ApplicationsBiosensors and Analytical Detection

Digital PCR: From early developments to its future application in clinics

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Trouchet, Amandine, Gines, Guillaume, Benhaim, Leonor, Taly, Valerie·2025·Lab on a Chip
DOI 10.1039/d5lc00055fPMC PMC12278255
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Abstract

This review explores the evolution of digital PCR (dPCR), highlighting early advancements, key technological innovations, and its promising future applications in clinical diagnostics, particularly in oncology and infectious diseases.

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200 of 391 shown

Cited by

Sorted by citations

Authors
Trouchet, A., Gines, G., Benhaim, L., & Taly, V.
Affiliations
  • Centre National de la Recherche Scientifique (FR)
  • Centre de Recherche des Cordeliers, UMRS1138, INSERM, CNRS, Sorbonne Université, USPC, Université Paris Cité, Equipe Labellisée Ligue Nationale Contre le Cancer, CNRS SNC 5096, Paris, France
ORCID
Venue
Lab on a Chip
Publisher
Royal Society of Chemistry (RSC)
Published
2025
Volume
25
Issue
16
Pages
3921-3961
ISSN
  • 1473-0189 (ISSN-L)
  • 1473-0197
DOI
10.1039/d5lc00055f
PMC
PMC12278255
OpenAlex
W4412516712
Cited by
43
References
3
Citations by year
2026: 37 · 2025: 6
FWCI
3.78
Type
journal article
Language
en
Open access
Licence
Locations
  • Lab on a Chip (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • HAL (submittedVersion, cc-by-nc)
Funders
  • Agence Nationale de la Recherche (AAPG2021-SNAPseq, ANR-21-CE19-0019)
  • Université de Recherche Paris Sciences et Lettres
  • École Supérieure de Physique et de Chimie Industrielles de la Ville de Paris
  • Centre National de la Recherche Scientifique
  • Institut National de la Santé et de la Recherche Médicale
  • Ligue Contre le Cancer (EL2016.LNCC/VaT)
  • H2020 European Research Council (949493)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Molecular Biology Techniques and Applications
  • Physical Sciences › Engineering › Biomedical Engineering › Microfluidic and Capillary Electrophoresis Applications
  • Physical Sciences › Engineering › Biomedical Engineering › Biosensors and Analytical Detection
Keywords
digital PCR, clinical application, virus detection, gene detection, antibiotic resistance genes, bacterial detection, point-of-care testing
MeSH terms
Digital Technology, Humans, Polymerase Chain Reaction

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