The DOI matches its OpenAlex record; 2 of the 2 references it cites were found in a registry or an index.
The protein disulphide-isomerase family: unravelling a string of folds
Open accessAbstract
The mammalian protein disulphide-isomerase (PDI) family encompasses several highly divergent proteins that are involved in the processing and maturation of secretory proteins in the endoplasmic reticulum. These proteins are characterized by the presence of one or more domains of roughly 95-110 amino acids related to the cytoplasmic protein thioredoxin. All but the PDI-D subfamily are composed entirely of repeats of such domains, with at least one domain containing and one domain lacking a redox-active -Cys-Xaa-Xaa-Cys- tetrapeptide. In addition to their known roles as redox catalysts and isomerases, the last few years have revealed additional functions of the PDI proteins, including peptide binding, cell adhesion and perhaps chaperone activities. Attention is now turning to the non-redox-active domains of the PDIs, which may play an important role in all of the known activities of these proteins. Thus the presence of both redox-active and -inactive domains within these proteins portends a complexity of functions differentially accommodated by the various family members.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837
Oxidized Redox State of Glutathione in the Endoplasmic Reticulum
Hwang, C., Sinskey, A. J., & Lodish, H. F. (1992) · Science · doi:10.1126/science.1523409 · Cited by 1,968
Cited by
de Marco, A. (2009) · Microbial Cell Factories · doi:10.1186/1475-2859-8-26 · Cited by 367
Jones, D. P., Go, Y.-M., Anderson, C. L., Ziegler, T. R., Kinkade, J. M., & Kirlin, W. G. (2004) · The FASEB Journal · doi:10.1096/fj.03-0971fje · Cited by 301
Intramolecular chaperones: polypeptide extensions that modulate protein folding
Shinde, U., & Inouye, M. (2000) · Seminars in Cell & Developmental Biology · doi:10.1006/scdb.1999.0349 · Cited by 141
Laurindo, F. R. M., Fernandes, D. C., Amanso, A. M., Lopes, L. R., & Santos, C. X. C. (2008) · Antioxidants & Redox Signaling · doi:10.1089/ars.2007.2011 · Cited by 87
Metadata
- Authors
- Ferrari, D. M., & Söling, H.
- Venue
- Biochemical Journal
- Publisher
- Portland Press
- Published
- 1999-03-25
- Volume
- 339
- Issue
- 1
- Pages
- 1-1
- ISSN
- 0264-6021 (ISSN-L)
- OpenAlex
- W2005145242
- Cited by
- 524
- References
- 2
- FWCI
- 11.35
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: The protein disulphide-isomerase family: unravelling a string of folds. https://app.cochat.ai/papers/10.1042/0264-6021:3390001
- The paper
- Ferrari, D. M., & Söling, H. (1999). The protein disulphide-isomerase family: unravelling a string of folds. Biochemical Journal. https://doi.org/10.1042/0264-6021%3A3390001
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
