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Identification of two human dimethylarginine dimethylaminohydrolases with distinct tissue distributions and homology with microbial arginine deiminases
Open accessAbstract
Methylarginines inhibit nitric oxide synthases (NOS). Cellular concentrations of methylarginines are determined in part by the activity of dimethylarginine dimethylaminohydrolase (DDAH; EC 3.5.3. 18). We have cloned human DDAH and identified and expressed a second novel DDAH isoform (DDAH I and II respectively). DDAH I predominates in tissues that express neuronal NOS. DDAH II predominates in tissues expressing endothelial NOS. These results strengthen the hypothesis that methylarginine concentration is actively regulated and identify molecular targets for the tissue and cell-specific regulation of methylarginine concentration.
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Citations
Cited by
Achan, V., Broadhead, M., Malaki, M., Whitley, G., Leiper, J., MacAllister, R., & Vallance, P. (2003) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000081742.92006.59 · Cited by 593
Self-citationThe role of nitric oxide in cardiovascular diseases
NASEEM, K. (2005) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2004.09.003 · Cited by 557
Vallance, P., & Leiper, J. (2004) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000128897.54893.26 · Cited by 553
Self-citationNitric Oxide and the Vascular Endothelium
Moncada, S., & Higgs, E. A. (2006) · Handbook of Experimental Pharmacology · doi:10.1007/3-540-32967-6_7 · Cited by 408
Asymmetrical Dimethylarginine: The Über Marker?
Cooke, J. P. (2004) · Circulation · doi:10.1161/01.cir.0000126823.07732.d5 · Cited by 396
Metadata
- Authors
- LEIPER, J. M., MARIA, J. S., Chubb, A., MacAllister, R. J., Charles, I. G., Whitley, G., & Vallance, P. J.
- Venue
- Biochemical Journal
- Publisher
- Portland Press
- Published
- 1999-09-24
- Volume
- 343
- Issue
- 1
- Pages
- 209-209
- ISSN
- 0264-6021 (ISSN-L)
- OpenAlex
- W2076680300
- Cited by
- 478
- References
- 0
- FWCI
- 5.88
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Identification of two human dimethylarginine dimethylaminohydrolases with distinct tissue distributions and homology with microbial arginine deiminases. https://app.cochat.ai/papers/10.1042/0264-6021:3430209
- The paper
- LEIPER, J. M., MARIA, J. S., Chubb, A., MacAllister, R. J., Charles, I. G., Whitley, G., & Vallance, P. J. (1999). Identification of two human dimethylarginine dimethylaminohydrolases with distinct tissue distributions and homology with microbial arginine deiminases. Biochemical Journal. https://doi.org/10.1042/0264-6021%3A3430209
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
