Cited by 396Nitric Oxide and Endothelin EffectsCancer-related gene regulationCardiovascular Health and Disease Prevention

Asymmetrical Dimethylarginine: The Über Marker?

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Cooke, John P.·2004·Circulation

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Crossref · 10.1161/01.cir.0000126823.07732.d5

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84 of 84 references verified0 citation errors · 0 not checkable

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  • Cardiovascular risk factors such as hypercholesterolemia and diabetes mellitus impair the synthesis and bioactivity of endothelium-derived NO.

    “Cardiovascular risk factors (e.g., hypercholesterolemia, diabetes mellitus) impair the synthesis and bioactivity of endothelium-derived NO (4, 5).”

    From Dietary nitrate, nitric oxide, and restenosis (2011) · cites this paper as [4]

  • The adverse effect of cardiovascular risk factors on the NOS pathway is mediated by asymmetric dimethylarginine and by vascular generation of superoxide anion, which degrades NO to peroxynitrite.

    “Their adverse effect on the NOS pathway is mediated by asymmetric dimethylarginine (ADMA; the endogenous antagonist of NO synthesis) and by the vascular generation of superoxide anion (O 2 -), which degrades NO to peroxynitrite anion (ONOO -) (4, 5).”

    From Dietary nitrate, nitric oxide, and restenosis (2011) · cites this paper as [4]

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1 of the 85 references couldn’t be matched to a known paper.

Research works printed but not linked: 4

  1. Stuhlinger MC, Oka RK, Graf EE, et al: Endothelial dysfunction induced by hyperhomocysteinemia: role of ADMA. Circulation. 2003;108: 933-938.
  2. Dayoub H, Achan V, Adimoolam S, et al. DDAH regulates NO synthesis: genetic and physiological evidence. Circulation. 2003;108:1043-1048.
  3. Weis M, Kledal TN, Lin KY, et al. Cytomegalovirus infection impairs the NOS pathway: role of ADMA in transplant arteriosclerosis. Circulation. 2004;109:500 -505.
  4. Stuhlinger MC, Abbasi F, Chu JW, et al. Relationship between insulin resistance and an endogenous nitric oxide synthase inhibitor. JAMA. 2002;287:1420 -1426.

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Authors
Cooke, J. P.
Affiliations
Stanford Medicine (US)
Corresponding author
Cooke, John P.
Venue
Circulation
Published
2004-04-20
Volume
109
Issue
15
Pages
1813-1818
ISSN
  • 0009-7322 (ISSN-L)
  • 1524-4539
OpenAlex
W2132464590
Cited by
396
References
85
Citations by year
2026: 6 · 2025: 9 · 2024: 3 · 2023: 3 · 2022: 2 · 2021: 9 · 2020: 4 · 2019: 14 · 2018: 16 · 2017: 13 · 2016: 18 · 2015: 10 · 2014: 17 · 2013: 21 · 2012: 26
FWCI
4.86
Type
journal article
Language
en
Open access
Locations
  • Circulation (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Tobacco-Related Disease Research Program
  • National Institute on Aging (P01 AG18784, P01AG018784)
  • National Heart, Lung, and Blood Institute (R01 HL00204, R01 HL-HL63685, R01 HL, R01HL063685)
Topics
  • Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer-related gene regulation
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
Keywords
asymmetric dimethylarginine, nitric oxide bioavailability, endothelial dysfunction, oxidative stress, nitric oxide synthase
MeSH terms
Amidohydrolases, Arginine, Arteriosclerosis, Blood Vessels, Endothelium, Vascular, Humans, Risk Factors, Vascular Resistance, Biomarkers, Nitric Oxide Synthase

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