Asymmetrical Dimethylarginine: The Über Marker?
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Cardiovascular risk factors such as hypercholesterolemia and diabetes mellitus impair the synthesis and bioactivity of endothelium-derived NO.
“Cardiovascular risk factors (e.g., hypercholesterolemia, diabetes mellitus) impair the synthesis and bioactivity of endothelium-derived NO (4, 5).”
From Dietary nitrate, nitric oxide, and restenosis (2011) · cites this paper as [4]
The adverse effect of cardiovascular risk factors on the NOS pathway is mediated by asymmetric dimethylarginine and by vascular generation of superoxide anion, which degrades NO to peroxynitrite.
“Their adverse effect on the NOS pathway is mediated by asymmetric dimethylarginine (ADMA; the endogenous antagonist of NO synthesis) and by the vascular generation of superoxide anion (O 2 -), which degrades NO to peroxynitrite anion (ONOO -) (4, 5).”
From Dietary nitrate, nitric oxide, and restenosis (2011) · cites this paper as [4]
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- Authors
- Cooke, J. P.
- Affiliations
- Stanford Medicine (US)
- Corresponding author
- Cooke, John P.
- ORCID
- Cooke, John P.
- Venue
- Circulation
- Published
- 2004-04-20
- Volume
- 109
- Issue
- 15
- Pages
- 1813-1818
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2132464590
- Cited by
- 396
- References
- 85
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 3 · 2023: 3 · 2022: 2 · 2021: 9 · 2020: 4 · 2019: 14 · 2018: 16 · 2017: 13 · 2016: 18 · 2015: 10 · 2014: 17 · 2013: 21 · 2012: 26
- FWCI
- 4.86
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Tobacco-Related Disease Research Program
- National Institute on Aging (P01 AG18784, P01AG018784)
- National Heart, Lung, and Blood Institute (R01 HL00204, R01 HL-HL63685, R01 HL, R01HL063685)
- Topics
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer-related gene regulation
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Keywords
- asymmetric dimethylarginine, nitric oxide bioavailability, endothelial dysfunction, oxidative stress, nitric oxide synthase
- MeSH terms
- Amidohydrolases, Arginine, Arteriosclerosis, Blood Vessels, Endothelium, Vascular, Humans, Risk Factors, Vascular Resistance, Biomarkers, Nitric Oxide Synthase
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