Cardiovascular Biology of the Asymmetric Dimethylarginine:Dimethylarginine Dimethylaminohydrolase Pathway

Arginine metabolism: nitric oxide and beyond

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Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure

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Asymmetric Dimethylarginine (ADMA): A Novel Risk Factor for Endothelial Dysfunction: Its Role in Hypercholesterolemia

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Plasma concentration of asymmetrical dimethylarginine and mortality in patients with end-stage renal disease: a prospective study

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Endogenous Nitric Oxide Synthase Inhibitor

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Homocysteine Impairs the Nitric Oxide Synthase Pathway

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Impaired Nitric Oxide Synthase Pathway in Diabetes Mellitus

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Novel Mechanism for Endothelial Dysfunction

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Asymmetric Dimethylarginine Causes Hypertension and Cardiac Dysfunction in Humans and Is Actively Metabolized by Dimethylarginine Dimethylaminohydrolase

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Relationship Between Insulin Resistance and an Endogenous Nitric Oxide Synthase Inhibitor

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Does ADMA Cause Endothelial Dysfunction?

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Endothelial dysfunction and raised plasma concentrations of asymmetric dimethylarginine in pregnant women who subsequently develop pre-eclampsia

Savvidou, M. D., Hingorani, A. D., Tsikas, D., Frölich, J. C., Vallance, P. J., & Nicolaides, K. H. (2003) · The Lancet · doi:10.1016/s0140-6736(03)13177-7 · Cited by 515 · see citing works

Effects of a nitric oxide synthase inhibitor in humans with septic shock

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Chronic inhibition of nitric oxide production accelerates neointima formation and impairs endothelial function in hypercholesterolemic rabbits.

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Identification of two human dimethylarginine dimethylaminohydrolases with distinct tissue distributions and homology with microbial arginine deiminases

LEIPER, J. M., MARIA, J. S., Chubb, A., MacAllister, R. J., Charles, I. G., Whitley, G. S. J., & Vallance, P. J. (1999) · Biochemical Journal · doi:10.1042/bj3430209 · Cited by 478 · see citing works

LDL Cholesterol Upregulates Synthesis of Asymmetrical Dimethylarginine in Human Endothelial Cells

Böger, R. H., Sydow, K., Borlak, J. T., Thum, T., Lenzen, H., Schubert, B., Tsikas, D., & Bode‐Böger, S. M. (2000) · Circulation Research · doi:10.1161/01.res.87.2.99 · Cited by 478 · see citing works

Biological significance of endogenous methylarginines that inhibit nitric oxide synthases

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State of the Arg

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Inhibition of nitric oxide synthesis in rats during pregnancy produces signs similar to those of preeclampsia

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Cardiovascular Effects of Systemic Nitric Oxide Synthase Inhibition With Asymmetrical Dimethylarginine in Humans

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Regulation of nitric oxide synthesis by dimethylarginine dimethylaminohydrolase

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The emerging role of asymmetric dimethylarginine as a novel cardiovascular risk factor

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Purification and properties of a new enzyme, N, N-dimethylarginine dimethylaminohydrolase, from rat kidney

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A Proteomic Analysis of Arginine-methylated Protein Complexes

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Prolonged blockade of nitric oxide synthesis in gravid rats produces sustained hypertension, proteinuria, thrombocytopenia, and intrauterine growth retardation

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Blocking NO synthesis: how, where and why?

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The DDAH/ADMA/NOS pathway

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Endothelial Dysfunction Induced by Hyperhomocyst(e)inemia

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S -nitrosylation of dimethylarginine dimethylaminohydrolase regulates enzyme activity: Further interactions between nitric oxide synthase and dimethylarginine dimethylaminohydrolase

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Plasma Concentration of Asymmetric Dimethylarginine, an Endogenous Inhibitor of Nitric Oxide Synthase, Is Elevated in Monkeys With Hyperhomocyst(e)inemia or Hypercholesterolemia

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Restoring vascular nitric oxide formation by l-arginine improves the symptoms of intermittent claudication in patients with peripheral arterial occlusive disease

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Long-term inhibition of NO synthesis promotes atherosclerosis in the hypercholesterolemic rabbit thoracic aorta. PGH2 does not contribute to impaired endothelium-dependent relaxation.

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Increased endogenous nitric oxide synthase inhibitor in patients with congestive heart failure

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An endogenous inhibitor of nitric oxide synthase regulates endothelial adhesiveness for monocytes

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Structural insights into the hydrolysis of cellular nitric oxide synthase inhibitors by dimethylarginine dimethylaminohydrolase.

Murray‐Rust, J., LEIPER, J. M., McAlister, M. S. B., Phelan, J. P., Tilley, S. J., MARIA, J. S., Vallance, P. J., & McDonald, N. Q. (2001) · Nature Structural Biology · doi:10.1038/90387 · Cited by 217 · see citing works

Elevation of asymmetrical dimethylarginine may mediate endothelial dysfunction during experimental hyperhomocyst(e)inaemia in humans

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Concentration of dimethyl-L-arginine in the plasma of patients with end-stage renal failure

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Chromosomal Localization, Gene Structure, and Expression Pattern of DDAH1: Comparison with DDAH2 and Implications for Evolutionary Origins

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Studies on the catabolism of NG-methylarginine, NG, NG-dimethylarginine and NG, NG-dimethylarginine in the rabbit

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Mechanism of Superoxide Generation by Neuronal Nitric-oxide Synthase

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Protein methylation

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Plasma concentrations of asymmetric dimethylarginine, a natural inhibitor of nitric oxide synthase, in normal pregnancy and preeclampsia

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NG-Methyl-L-arginine functions as an alternate substrate and mechanism-based inhibitor of nitric oxide synthase

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Plasma concentrations of endogenous inhibitor of nitric oxide synthesis in normal pregnancy and pre-eclampsia

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Metformin treatment lowers asymmetric dimethylarginine concentrations in patients with type 2 diabetes

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Effects of guanidino and uremic compounds on nitric oxide pathways

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Detection of NG,NGDimethylarginine Dimethylaminohydrolase in Human Tissues Using a Monoclonal Antibody

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Occurrence of a new enzyme catalyzing the direct conversion of NG,NG-dimethyl-L-arginine to L-citrulline in rats

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Nitric oxide synthase inhibitors and hypertension in children and adolescents

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Plasma Levels of Asymmetrical Dimethyl-l-Arginine in Patients with Congenital Heart Disease and Pulmonary Hypertension

Gorenflo, M., Zheng, C., Werle, E., Fiehn, W., & Ulmer, H. E. (2001) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-200104000-00016 · Cited by 150 · see citing works

Association of Asymmetric Dimethylarginine and Endothelial Dysfunction

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all- trans -Retinoic Acid Increases Nitric Oxide Synthesis by Endothelial Cells

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Regulation of Cytokine-Induced Nitric Oxide Synthesis by Asymmetric Dimethylarginine

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Hypertension Does Not Account for the Accelerated Atherosclerosis and Development of Aneurysms in Male Apolipoprotein E/Endothelial Nitric Oxide Synthase Double Knockout Mice

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Metabolism of NG,NG- and NG,NG-dimethylarginine in rats

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Angiogenesis Is Impaired by Hypercholesterolemia

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Metabolism of Asymmetric Dimethylarginines Is Regulated in the Lung Developmentally and With Pulmonary Hypertension Induced by Hypobaric Hypoxia

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Induction of NG-monomethyl-L-arginine uptake: a mechanism for differential inhibition of NO synthases?

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Accumulation of endogenous inhibitors for nitric oxide synthesis and decreased content of L‐arginine in regenerated endothelial cells

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Evidence for Dysregulation of Dimethylarginine Dimethylaminohydrolase I in Chronic Hypoxia–Induced Pulmonary Hypertension

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Estrogen Stimulates Dimethylarginine Dimethylaminohydrolase Activity and the Metabolism of Asymmetric Dimethylarginine

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Hemodialysis and L-arginine, but not D-arginine, correct renal failure-associated endothelial dysfunction

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Importance of asymmetrical dimethylarginine in cardiovascular risk

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Effect of Shear Stress on Asymmetric Dimethylarginine Release From Vascular Endothelial Cells

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Effects of systemic NO synthesis inhibition on RPF, GFR, UNa, and vasoactive hormones in healthy humans

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Elevation of an endogenous inhibitor of nitric oxide synthesis in experimental congestive heart failure

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Dimethylarginine dimethylaminohydrolase I enhances tumour growth and angiogenesis

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Identification of methylated proteins by protein arginine N-methyltransferase 1, PRMT1, with a new expression cloning strategy

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Dialysis improves endothelial function in humans

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Dimethylarginine:pyruvate aminotransferase in rats. Purification, properties, and identity with alanine:glyoxylate aminotransferase 2.

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Plasma concentrations of asymmetric-dimethyl-arginine in type 2 diabetes associate with glycemic control and glomerular filtration rate but not with risk factors of vasculopathy

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Synthesis of NG, NGDimethylarginine by Human Endothelial Cells

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Dimethylarginine dimethylaminohydrolase activity modulates ADMA levels, VEGF expression, and cell phenotype

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Isolation and identification of NG-Monomethyl NG, NG-Dimethyl- and NG,NG-Dimethylarginine from the hydrolysate of proteins of bovine brain

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High plasma level of asymmetric dimethylarginine in patients with acutely exacerbated congestive heart failure: role in reduction of plasma nitric oxide level

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N G , N G -Dimethylarginine and N G , N ' G -dimethylarginine in renal insufficiency

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Distribution of Free Methylarginines in Rat Tissues and in the Bovine Brain

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Acute administration of L-arginine does not improve arterial endothelial function in chronic renal failure

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Common genetic variation in a basal promoter element alters DDAH2 expression in endothelial cells

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Elevated Levels of the Serum Endogenous Inhibitor of Nitric Oxide Synthase and Metabolic Control in Rats With Streptozotocin-Induced Diabetes

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Effects of overexpression of dimethylarginine dimethylaminohydrolase on tumor angiogenesis assessed by susceptibility magnetic resonance imaging.

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N G,N G-Dimethylarginine and N G,N'G-dimethylarginine in renal insufficiency

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Structural and Functional Characterization of the Zn(II) Site in Dimethylargininase-1 (DDAH-1) from Bovine Brain

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Participation of nitric oxide in the regulation of renal function

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Asymmetric dimethylarginine and total homocysteine in plasma after oral methionine loading

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Characterization of Dimethylargininase from Bovine Brain: Evidence for a Zinc Binding Site

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Insulin Resistance, ADMA Levels, and Cardiovascular Disease

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THE STUDY ON THE ROLE OF THE SUBSTRATE,INHIBITOR OF NOS AND PROVIDER OF NO IN RABBITS' INFECTION BY EIMERIA STIEDAI

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