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Carnitine biosynthesis in mammals
Open accessAbstract
Carnitine is indispensable for energy metabolism, since it enables activated fatty acids to enter the mitochondria, where they are broken down via beta-oxidation. Carnitine is probably present in all animal species, and in numerous micro-organisms and plants. In mammals, carnitine homoeostasis is maintained by endogenous synthesis, absorption from dietary sources and efficient tubular reabsorption by the kidney. This review aims to cover the current knowledge of the enzymological, molecular, metabolic and regulatory aspects of mammalian carnitine biosynthesis, with an emphasis on the human and rat.
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Metadata
- Authors
- Vaz, F. M., & Wanders, R. J. A.
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 2002-01-25
- Volume
- 361
- Issue
- 3
- Pages
- 417-429
- ISSN
- 0264-6021 (ISSN-L)
- 1470-8728
- OpenAlex
- W2067669340
- Cited by
- 764
- References
- 6
- FWCI
- 7.55
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
