The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
microRNAs: small molecules with big roles –C. elegans to human cancer
Abstract
miRNAs (microRNAs) were first discovered as critical regulators of developmental timing events in Caenorhabditis elegans. Subsequent studies have shown that miRNAs and cellular factors necessary for miRNA biogenesis are conserved in many organisms, suggesting the importance of miRNAs during developmental processes. Indeed, mutations in the miRNA‐processing pathway induce pleiotropic defects in development, which accompany perturbation of correct expression of target genes. However, control of gene expression in development is not the only function of miRNAs. Recent work has provided new insights into the role of miRNAs in various biological events, including aging and cancer. C. elegans continues to be helpful in facilitating a further understanding of miRNA function in human diseases.
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Cites
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“Although the precise mechanisms regulating lifespan are still not well understood, one model suggests that temporal activation of a timer gene may initiate the aging programme early in the adult stage (McCarroll et al., 2004).”
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Cited by
Therapeutic microRNA Delivery Suppresses Tumorigenesis in a Murine Liver Cancer Model
Kota, J., Chivukula, R. R., O'Donnell, K. A., Wentzel, E. A., Montgomery, C. L., Hwang, H.-W., Chang, T.-C., Vivekanandan, P., Torbenson, M., Clark, K. R., et al. (2009) · Cell · doi:10.1016/j.cell.2009.04.021 · Cited by 1,452
The control of developmental phase transitions in plants
Huijser, P., & Schmid, M. (2011) · Development · doi:10.1242/dev.063511 · Cited by 673
Recurrent Somatic DICER1 Mutations in Nonepithelial Ovarian Cancers
Heravi-Moussavi, A., Anglesio, M. S., Cheng, S.-W. G., Senz, J., Yang, W., Prentice, L., Fejes, A. P., Chow, C., Tone, A., Kalloger, S. E., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1102903 · Cited by 466
Lee, C., Kim, M.-J., Kumar, A., Lee, H.-W., Yang, Y., & Kim, Y. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02249-0 · Cited by 365
microRNA Expression Patterns Reveal Differential Expression of Target Genes with Age
Noren Hooten, N., Abdelmohsen, K., Gorospe, M., Ejiogu, N., Zonderman, A. B., & Evans, M. K. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010724 · Cited by 357
Metadata
- Authors
- Kato, M., & Slack, F. J.
- Venue
- Biology of the Cell
- Publisher
- Wiley
- Published
- 2008-02
- Volume
- 100
- Issue
- 2
- Pages
- 71-81
- ISSN
- 0248-4900 (ISSN-L)
- 1768-322X
- OpenAlex
- W2030966629
- Cited by
- 185
- References
- 11
- FWCI
- 6.87
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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