Chemosensory neurons with overlapping functions direct chemotaxis to multiple chemicals in C. elegans
Abstract
The functions of the 11 classes of exposed chemosensory neurons of C. elegans were tested by killing cells with a laser microbeam. One pair of neurons, the ASE neurons, is uniquely important for chemotaxis: killing the ASE neurons greatly reduced chemotaxis to cAMP, biotin, Cl-, and Na+. Additional chemosensory function is distributed among several other cell types. Thus, 3 pairs of chemosensory neurons (ADF, ASG, and ASI) contribute to a residual response to cAMP, biotin, Cl-, and Na+ after ASE is killed. Chemotaxis to lysine similarly depends on the partly redundant functions of 4 pairs of chemosensory neurons (ASE, ASG, ASI, and ASK). The combined activity of several neuron types that act in parallel might increase the fidelity of chemotaxis.
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Chemotaxis to sodium and chloride ions is mediated mainly by the ASE sensory neurons.
“Studies have shown that chemotaxis to sodium and chloride ions are mediated mainly by the ASE sensory neurons [68].”
From Connecting a Connectome to Behavior: An Ensemble of Neuroanatomical Models of C. elegans Klinotaxis (2013) · cites this paper as [68]
Simultaneous ablation of all amphid and phasmid neurons except ASE spares chemotaxis, indicating that the role of ASE in water-soluble chemotaxis is unique.
“Simultaneous ablation of all amphid and phasmid neurons except ASE spares chemotaxis, indicating that the role of ASE in water-soluble chemotaxis is unique [68].”
From Connecting a Connectome to Behavior: An Ensemble of Neuroanatomical Models of C. elegans Klinotaxis (2013) · cites this paper as [68]
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- Authors
- Bargmann, C. I., & Horvitz, H. R.
- Affiliations
- Howard Hughes Medical Institute (US)
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 1991-11
- Volume
- 7
- Issue
- 5
- Pages
- 729-742
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2099763381
- Cited by
- 740
- References
- 2
- Citations by year
- 2026: 17 · 2025: 50 · 2024: 25 · 2023: 26 · 2022: 23 · 2021: 28 · 2020: 50 · 2019: 29 · 2018: 28 · 2017: 29 · 2016: 18 · 2015: 25 · 2014: 28 · 2013: 36 · 2012: 22
- FWCI
- 1.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of General Medical Sciences (GM 24663)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- chemosensory neurons, chemotaxis, Caenorhabditis elegans, AFD neurons, cyclic AMP, biotin, chloride, sodium, lysine
- MeSH terms
- Cyclic AMP, Animals, Biotin, Caenorhabditis, Chemoreceptor Cells, Chemotaxis, Electrolytes, Lasers, Neurons, Afferent
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