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Chemistry of Thyroxine
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Research Article| January 01 1927 Chemistry of Thyroxine: Constitution and Synthesis of Thyroxine Charles Robert Harington; Charles Robert Harington 1The Department of Pathological Chemistry, University College Hospital Medical School, London, and the Department of Medical Chemistry, University of Edinburgh Search for other works by this author on: This Site PubMed Google Scholar George Barger George Barger 1The Department of Pathological Chemistry, University College Hospital Medical School, London, and the Department of Medical Chemistry, University of Edinburgh Search for other works by this author on: This Site PubMed Google Scholar Biochem J (1927) 21 (1): 169–183. https://doi.org/10.1042/bj0210169 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation Charles Robert Harington, George Barger; Chemistry of Thyroxine: Constitution and Synthesis of Thyroxine. Biochem J 1 January 1927; 21 (1): 169–183. doi: https://doi.org/10.1042/bj0210169 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Journal Search Advanced Search © 1927 CAMBRIDGE UNIVERSITY PRESS1927 Article PDF first page preview Close Modal You do not currently have access to this content.
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“second, the synthesis of T4 (32) and its better-absorbed sodium salt by Chalmers et al. (33);”
From Guidelines for the Treatment of Hypothyroidism: Prepared by the American Thyroid Association Task Force on Thyroid Hormone Replacement (2014) · cites this paper as [32]
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Harington, C. R. (1926) · Biochemical Journal · doi:10.1042/bj0200300 · Cited by 121
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Jonklaas, J., Bianco, A. C., Bauer, A. J., Burman, K. D., Cappola, A. R., Celi, F. S., Cooper, D. S., Kim, B. W., Peeters, R. P., Rosenthal, M. S., et al. (2014) · Thyroid® · doi:10.1089/thy.2014.0028 · Cited by 1,928
“Three factors were likely responsible for LT4 becoming the predominant therapy in the latter half of the 20th century: first, the isolation of T4 in 1927 by Kendall (31); second, the synthesis of T4 (32) and its better-absorbed sodium salt by Chalmers et al.”
Aromatic Nucleophilic Substitution Reactions.
Bunnett, J. F., & Zahler, R. E. (1951) · Chemical Reviews · doi:10.1021/cr60153a002 · Cited by 1,035
The Deiodinase Family of Selenoproteins
GERMAIN, D. L. S., & GALTON, V. A. (1997) · Thyroid · doi:10.1089/thy.1997.7.655 · Cited by 342
Regulation of gene expression by thyroid hormone.
Samuels, H. H., FORMAN, B. M., Horowitz, Z. D., & Ye, Z. S. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113449 · Cited by 308
The Role of Thyroid Hormones for Brain Development and Cognitive Function
ROVET, J. F. (2014) · Endocrine development · doi:10.1159/000363153 · Cited by 205
Metadata
- Authors
- Harington, C. R., & Barger, G.
- Affiliations
- University College Hospital (GB)
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 1927-01-01
- Volume
- 21
- Issue
- 1
- Pages
- 169-183
- ISSN
- 0306-3283 (ISSN-L)
- PMC
- PMC1251886
- OpenAlex
- W2193104832
- Cited by
- 319
- References
- 1
- Citations by year
- 2025: 4 · 2024: 5 · 2023: 5 · 2022: 8 · 2021: 8 · 2020: 4 · 2019: 8 · 2018: 5 · 2017: 1 · 2016: 8 · 2015: 5 · 2014: 9 · 2013: 9 · 2012: 1
- FWCI
- 16.09
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biochemical Journal (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Physical Sciences › Chemistry › Organic Chemistry › Steroid Chemistry and Biochemistry
- Keywords
- thyroxine, chemical constitution, synthesis, thyroid hormones, iodinated thyroid hormones, organic synthesis
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