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Metabolism of amino-acids
Open accessAbstract
Oxidation of 1 ( + )-glutamic acid without formation of ammonia.THE starting-point of this investigation was the observation that glutamic acid behaves differently from all the other ax-amino-acids in guinea-pig and rabbit kidneys, in that, although it increases the oxygen uptake even more than any other amino-acid of the i-series, in most cases it actually diminishes ammonia formation.In guinea-pig kidney, the oxygen uptake is increased about 100-150% (Table I) whilst in most experiments no ammonia at all is detectable in the presence of 1( + )-glutamic acid [Krebs, 1933, 2]1.
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Cited by
Danbolt, N. C. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00067-8 · Cited by 4,227
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Altman, B. J., Stine, Z. E., & Dang, C. V. (2016) · Nature Reviews Cancer · doi:10.1038/nrc.2016.71 · Cited by 2,119
Glutamine: Metabolism and Immune Function, Supplementation and Clinical Translation
Cruzat, V., Macedo Rogero, M., Noel Keane, K., Curi, R., & Newsholme, P. (2018) · Nutrients · doi:10.3390/nu10111564 · Cited by 1,261
Glutamine: Metabolism and Immune Function, Supplementation and Clinical Translation
Cruzat, V., Macedo Rogero, M., Noel Keane, K., Curi, R., & Newsholme, P. (2018) · doi:10.20944/preprints201809.0459.v1 · Cited by 1,261
Antitumor activity of the glutaminase inhibitor CB-839 in triple-negative breast cancer
Gross, M. I., Demo, S. D., Dennison, J. B., Chen, L., Chernov-Rogan, T., Goyal, B., Janes, J. R., Laidig, G. J., Lewis, E. R., Li, J., et al. (2014) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-13-0870 · Cited by 1,068
Metadata
- Authors
- Krebs, H. A.
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 1935-08-01
- Volume
- 29
- Issue
- 8
- Pages
- 1951-1969
- ISSN
- 0306-3283 (ISSN-L)
- OpenAlex
- W73242948
- Cited by
- 571
- References
- 0
- FWCI
- 2.19
- Type
- journal article
- Language
- en
- Open access
- bronze
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