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Cited by 10Vitamin C and Antioxidants ResearchAntioxidant Activity and Oxidative StressAlcoholism and Thiamine Deficiency

The behaviour of l-ascorbic acid and chemically related compounds in the animal body. The influence of generalised ether anaesthesia on their urinary excretion

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Zilva, Sylvester Solomon·1935·Biochemical Journal
DOI 10.1042/bj0292366PMC PMC1266768
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Abstract

IN a recent communication [Zilva, 1935] evidence was produced showing that when compounds of the ascorbic acid series, i.e.I-ascorbic acid, d-arabo-ascorbic acid, d-galacto-ascorbic acid, d-gluco-ascorbic acid, 1-gluco-ascorbic acid, were injected into guinea-pigs previously depleted of vitamin C, only the anti- scorbutically active members were " fixed " by their tissues.In addition there was an indication that a quantitative relationship existed between the degree of activity and the amount "fixed", since the tissues of the animals injected with

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  • Erythorbic acid and D-ascorbic acid are partly active as vitamin C but are poorly retained by tissues and more rapidly excreted from the human body.

    “Its epimer erythorbic acid (Figure 1B, also known as isoascorbic acid or D-araboascorbic acid), which is used as a food additive, and its enantiomer D-ascorbic acid (Figure 1C) are also partly active as vitamin C. However, they are only poorly retained by tissues and are more rapidly excreted from the human body [7,8,9,10].”

    From Vitamin C-Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination (2021) · cites this paper as [10]

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Authors
Zilva, S. S.
Affiliations
Lister Institute of Preventive Medicine (GB)
Corresponding author
Zilva, Sylvester Solomon
Venue
Biochemical Journal
Publisher
Portland Press Ltd.
Published
1935-10-01
Volume
29
Issue
10
Pages
2366-2368
ISSN
0306-3283 (ISSN-L)
DOI
10.1042/bj0292366
PMC
PMC1266768
OpenAlex
W2198852903
Cited by
10
References
2
Citations by year
2021: 1
FWCI
2.92
Type
journal article
Language
en
Open access
Locations
  • Biochemical Journal (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Vitamin C and Antioxidants Research
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
  • Health Sciences › Medicine › Neurology › Alcoholism and Thiamine Deficiency
Keywords
vitamin C, urinary excretion, ether anesthesia, scurvy, guinea pig

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