The amino-acid sequence in the phenylalanyl chain of insulin. 1. The identification of lower peptides from partial hydrolysates
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Ala, Leu] refers to a peptide or peptides containing glycine, alanine and leucine, in which the free amino group is on the glycine residue, but the relative order of the alanine and leucine residues is unknown.The residues having the free a-amino groups in peptides will be referred to as N-terminal residues, those with free oc-carboxyl groups as C-terminal residues.
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Frederick Sanger determined the amino acid sequences of the A and B chains of insulin; by 1955 he demonstrated the position of the two disulfide bonds linking the A and B chains and the intrachain disulfide bond within the A chain.
“In the early 1950s, Frederick Sanger determined the amino acid sequences of the A and B chains of insulin87–90. By 1955, he would demonstrate the position of the two disulfide bonds linking the A and B chains and the intrachain disulfide bond within the A chain, and in 1958, he was awarded the Nobel Prize in Chemistry91–93.”
From 100 years of insulin: celebrating the past, present and future of diabetes therapy (2021) · cites this paper as [87]
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- Synge, R. L. M. (1951). Biochem. J. (in the Press).
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INGRAM, V. M. (1957) · Nature · doi:10.1038/180326a0 · Cited by 978 · see citing works
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100 years of insulin: celebrating the past, present and future of diabetes therapy
Sims, E. K., Carr, A. L. J., Oram, R. A., DiMeglio, L. A., & Evans-Molina, C. (2021) · Nature Medicine · doi:10.1038/s41591-021-01418-2 · Cited by 270 · see citing works
Sanger, F. (1959) · Science · doi:10.1126/science.129.3359.1340 · Cited by 255 · see citing works
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- Authors
- Sanger, F., & Tuppy, H.
- Affiliations
- University of Cambridge (GB)
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 1951-09-01
- Volume
- 49
- Issue
- 4
- Pages
- 463-481
- ISSN
- 0306-3283 (ISSN-L)
- PMC
- PMC1197535
- OpenAlex
- W1756039870
- Cited by
- 784
- References
- 0
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 12 · 2023: 12 · 2022: 34 · 2021: 13 · 2020: 13 · 2019: 14 · 2018: 13 · 2017: 11 · 2016: 15 · 2015: 10 · 2014: 16 · 2013: 11 · 2012: 5
- FWCI
- 145.15
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Biochemical Journal (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chemical Synthesis and Analysis
- Keywords
- insulin, amino acid sequence, peptide identification, N-terminal residues, C-terminal residues
- MeSH terms
- Amino Acid Sequence, Insulin, Peptides
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