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Cited by 296

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Regulation of glucose uptake by muscles. 10. Effects of alloxan-diabetes, starvation, hypophysectomy and adrenalectomy, and of fatty acids, ketone bodies and pyruvate, on the glycerol output and concentrations of free fatty acids, long-chain fatty acyl-coenzyme A, glycerol phosphate and citrate-cycle intermediates in rat heart and diaphragm muscles

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Garland, PB, Randle, PJ·1964·Biochemical Journal

Abstract

dihydroxyacetone phosphate ratio in the muscles was increased by butyrate and decreased by diabetes and starvation.6.It is concluded: that the oxidation ofpyruvate in rat heart and rat diaphragm muscles may be inhibited in diabetes because of the greater availability of fatty acids and ketone bodies for respiration in this condition; that glycolysis in these muscles is not reversible to any significant extent; that the NADH2/NAD ratio in cell sap is increased by glucose, anoxia, salicylate, fatty acids and ketone bodies, and diminished in allox- an-diabetes and starvation.7. The possibility that the inhibitory effects of diabetes, fatty acids and ketone bodies on pyruvate oxidation are due to inhibition of pyruvate de- hydrogenase by a rise in the acetyl-CoA/CoA ratio is discussed.We thank the British Diabetic Association and the British Insulin Manufacturers for grants that contributed to the cost of these investigations, Evans Medical Ltd. for a generous gift of heparin, and Mrs W. Thorne for skilled technical assistance.

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Metadata

Authors
Garland, P., & Randle, P.
Venue
Biochemical Journal
Published
1964-12-01
Volume
93
Issue
3
Pages
678-687
ISSN
0006-2936 (ISSN-L)
OpenAlex
W177044521
Cited by
296
References
1
FWCI
7.19
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Regulation of glucose uptake by muscles. 10. Effects of alloxan-diabetes, starvation, hypophysectomy and adrenalectomy, and of fatty acids, ketone bodies and pyruvate, on the glycerol output and concentrations of free fatty acids, long-chain fatty acyl-coenzyme A, glycerol phosphate and citrate-cycle intermediates in rat heart and diaphragm muscles. https://app.cochat.ai/papers/10.1042/bj0930678
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Garland, P., & Randle, P. (1964). Regulation of glucose uptake by muscles. 10. Effects of alloxan-diabetes, starvation, hypophysectomy and adrenalectomy, and of fatty acids, ketone bodies and pyruvate, on the glycerol output and concentrations of free fatty acids, long-chain fatty acyl-coenzyme A, glycerol phosphate and citrate-cycle intermediates in rat heart and diaphragm muscles. Biochemical Journal. https://doi.org/10.1042/bj0930678

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