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Cathepsin D. Characteristics of immunoinhibition and the confirmation of a role in cartilage breakdown
Open accessAbstract
1. Antisera were raised against lysosomal cathepsin D of man, chicken and rabbit. 2. The antisera were found to be specific and potent inhibitors of cathepsin D activity. 3. The immunological nature of the inhibition was established. 4. The inhibitory effect was studied by varying pH, antiserum/enzyme ratio, time of incubation, concentration of components and order of mixing, and by using purified antibody and univalent antibody fragments. 5. The specificities of the antisera were examined with respect to other enzymes, isoenzymes of cathepsin D and cathepsin D from different organs. 6. The antisera prevented the action of cathepsin D on isolated proteoglycans and on cartilage. 7. The antisera produced up to 90% inhibition of the autolysis of cartilage from chicks and rabbits, indicating that cathepsin D is the enzyme mainly responsible for the breakdown of proteoglycans in this system.
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Citations
Cited by
Effects of vitamin A and its analogs (retinoids) on normal and neoplastic cells
Lotan, R. (1980) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/0304-419x(80)90021-9 · Cited by 1,072
Proteases involved in cartilage matrix degradation in osteoarthritis
Troeberg, L., & Nagase, H. (2012) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2011.06.020 · Cited by 579
Vitamin A Transport in Human Vitamin A Toxicity
Smith, F. R., & Goodman, D. S. (1976) · New England Journal of Medicine · doi:10.1056/nejm197604082941503 · Cited by 316
PLASMA RETINOL‐BINDING PROTEIN*
Goodman, D. S. (1980) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1980.tb21314.x · Cited by 276
Plasma Retinol-Binding Protein
GOODMAN, D. S. (1984) · The Retinoids · doi:10.1016/b978-0-12-658102-7.50008-7 · Cited by 268
Metadata
- Authors
- Dingle, J. T., Barrett, A. J., & Weston, P. D.
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 1971-06-01
- Volume
- 123
- Issue
- 1
- Pages
- 1-13
- ISSN
- 0306-3283 (ISSN-L)
- OpenAlex
- W110330828
- Cited by
- 180
- References
- 0
- FWCI
- 17.15
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Dingle, J. T., Barrett, A. J., & Weston, P. D. (1971). Cathepsin D. Characteristics of immunoinhibition and the confirmation of a role in cartilage breakdown. Biochemical Journal. https://doi.org/10.1042/bj1230001
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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