The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Vitamin A Transport in Human Vitamin A Toxicity
Abstract
The plasma retinol transport system was studied in three patients with chronic hypervitaminosis A. The toxic state in each was associated with increased plasma concentrations of total vitamin A, and particularly of retinyl esters. The concentrations of plasma retinol-binding protein and prealbumin were, in contrast, non to retinol-binding protein. These limited clinical data support conclusions from detailed studies with hypervitaminotic rats, which suggest that vitamin A toxicity occurs when excessive amounts of vitamin A are presented to cell membranes in association with plasma lipoproteins, rather than specifically bound to retinol-binding protein. Retinol-binding protein may not only regulate the supply of retinol to tissues but also protect tissues from the surface-active properties of the vitamin.
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Citations
Cites
Retinol-binding protein: the transport protein for vitamin A in human plasma
Kanai, M., Raz, A., & Goodman, D. S. (1968) · Journal of Clinical Investigation · doi:10.1172/jci105889 · Cited by 899
Self-citationSmith, F. R., & Goodman, D. S. (1971) · Journal of Clinical Investigation · doi:10.1172/jci106741 · Cited by 447
Self-citationThe intestinal absorption and metabolism of vitamin A and beta-carotene in man.
Goodman, D. S., Blomstrand, R., Werner, B., Huang, H. S., & Shiratori, T. (1966) · Journal of Clinical Investigation · doi:10.1172/jci105468 · Cited by 349
Self-citationFluorometric determination of vitamin A in human blood and liver
Thompson, J. N., Erdody, P., Brien, R., & Murray, T. K. (1971) · Biochemical Medicine · doi:10.1016/0006-2944(71)90076-7 · Cited by 324
FELL, H., & DINGLE, J. (1963) · Biochemical Journal · doi:10.1042/bj0870403 · Cited by 293
Tissue distribution and metabolism of newly absorbed vitamin A in the rat
Goodman, D. S., Huang, H. S., & Shiratori, T. (1965) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)39309-3 · Cited by 292
Self-citationIsolation and properties of a human retinol-transporting protein
Peterson, P. A., & Berggård, I. (1971) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)62527-x · Cited by 207
Hepatic Injury from Chronic Hypervitaminosis a Resulting in Portal Hypertension and Ascites
Russell, R. M., Boyer, J. L., Bagheri, S. A., & Hruban, Z. (1974) · New England Journal of Medicine · doi:10.1056/nejm197408292910903 · Cited by 205
Dingle, J. T., Barrett, A. J., & Weston, P. D. (1971) · Biochemical Journal · doi:10.1042/bj1230001 · Cited by 180
Chronic vitamin A intoxication in adults
Muenter, M. D., Perry, H. O., & Ludwig, J. (1971) · The American Journal of Medicine · doi:10.1016/0002-9343(71)90212-9 · Cited by 178
Cited by
Effects of vitamin A and its analogs (retinoids) on normal and neoplastic cells
Lotan, R. (1980) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/0304-419x(80)90021-9 · Cited by 1,072
Hepatic lipocytes: the principal collagen-producing cells of normal rat liver.
Friedman, S. L., Roll, F. J., Boyles, J., & Bissell, D. M. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.24.8681 · Cited by 859
Vitamin A and retinoids in health and disease
Epstein, F. H., & Goodman, D. S. (1984) · New England Journal of Medicine · doi:10.1056/nejm198404193101605 · Cited by 553
Self-citationImdad, A., Mayo-Wilson, E., Herzer, K., & Bhutta, Z. A. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008524.pub3 · Cited by 513
Biomarkers of Nutrition for Development (BOND)-Vitamin A Review
Tanumihardjo, S. A., Russell, R. M., Stephensen, C. B., Gannon, B. M., Craft, N. E., Haskell, M. J., Lietz, G., Schulze, K., & Raiten, D. J. (2016) · The Journal of Nutrition · doi:10.3945/jn.115.229708 · Cited by 451
Metadata
- Authors
- Smith, F. R., & Goodman, D. S.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1976-04-08
- Volume
- 294
- Issue
- 15
- Pages
- 805-808
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2319019236
- Cited by
- 316
- References
- 23
- FWCI
- 3.53
- Type
- journal article
- Language
- en
- Open access
- closed
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Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
