Hypoxia-inducible factor asparaginyl hydroxylase (FIH-1) catalyses hydroxylation at the β-carbon of asparagine-803

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Items 101–200 of 215

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2. Mutual Regulation between Redox and Hypoxia-Inducible Factors in Cardiovascular and Renal Complications of Diabetes
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3. Hypoxia-Inducible Factor (HIF): Fuel for Cancer Progression
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4. Structural Basis of Prolyl Hydroxylase Domain Inhibition by Molidustat
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5. Incorporation of oxygen into the succinate co‐product of iron(II) and 2‐oxoglutarate dependent oxygenases from bacteria, plants and humans
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6. Contributions of the α6 Integrins to Breast Carcinoma Survival and Progression
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7. Auto-hydroxylation of FIH-1: an Fe(ii), α-ketoglutarate-dependent human hypoxia sensor
   Yuan-Han Chen, Lindsay M. Comeaux, Stephen J. Eyles, Michael J. Knapp · 2008 · Chemical Communications
8. Hypoxia as a target for drug combination therapy of liver cancer
   Cressida J. Bowyer, Andrew L. Lewis, Andrew W. Lloyd, Gary J. Phillips, Wendy M. Macfarlane · 2017 · Anti-Cancer Drugs
9. MgcRacGAP Interacts with HIF-1α and Regulates its Transcriptional Activity
   Aggeliki Lyberopoulou, Emmanouil Venieris, Ilias Mylonis, Georgia Chachami, Ioannis S. Pappas, George Simos, Sofia Bonanou, Eleni Georgatsou · 2007 · Cellular Physiology and Biochemistry
10. 2-Oxoglutarate derivatives can selectively enhance or inhibit the activity of human oxygenases
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11. Overexpression of post-translationally modified peptides in Escherichia coli by co-expression with modifying enzymes
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12. Breakthrough science: hypoxia-inducible factors, oxygen sensing, and disorders of hematopoiesis
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14. Precision Mechanics with Multifunctional Tools: How HnRNP K and HnRNPs E1/E2 Contribute to Post-Transcriptional Control of Gene Expression in Hematopoiesis
    Antje Ostareck‐Lederer, Dirk H. Ostareck · 2012 · Current Protein and Peptide Science
15. Fine tuning the HIF‐1 ‘global’ O2 sensor for hypobaric hypoxia in Andean high‐altitude natives
    Peter W. Hochachka, Jim L. Rupert · 2003 · BioEssays
16. Hypoxia-Induced Vascular Endothelial Growth Factor Transcription and Protection from Apoptosis Are Dependent on α6β1 Integrin in Breast Carcinoma Cells
    Jun Chung, Sang-Oh Yoon, Kaustubh Datta, Robin E. Bachelder, Arthur M. Mercurio · 2004 · Cancer Research
17. New Classes of Mind Bomb-Interacting Proteins Identified from Yeast Two-Hybrid Screens
    Li-Chuan Tseng, Chengjin Zhang, Chun-Mei Cheng, Haoying Xu, Chia-Hao Hsu, Yun‐Jin Jiang · 2014 · PLoS ONE
18. The inhibition of factor inhibiting hypoxia-inducible factor (FIH) by β-oxocarboxylic acids
    Biswadip Banerji, Ana Conejo‐García, Luke A. McNeill, M.A. McDonough, Matthew R. Buck, Kirsty S. Hewitson, Neil J. Oldham, Christopher John Schofield · 2005 · Chemical Communications
19. Therapeutic Effects and Molecular Mechanism of Chlorogenic Acid on Polycystic Ovarian Syndrome: Role of HIF-1alpha
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20. The Second Coordination Sphere of FIH Controls Hydroxylation
    Evren Saban, Yuan-Han Chen, John A. Hangasky, Cornelius Y. Taabazuing, Breanne E. Holmes, Michael J. Knapp · 2011 · Biochemistry
21. The Engaged Role of Tumor Microenvironment in Cancer Metabolism: Focusing on Cancer-Associated Fibroblast and Exosome Mediators
    Khandan Ilkhani, Milad Bastami, Soheila Delgir, Asma Safi, Shahrzad Talebian, Mohammad Reza Alivand · 2020 · Anti-Cancer Agents in Medicinal Chemistry
22. Catalytic mechanism and substrate specificity of HIF prolyl hydroxylases
    N. A. Smirnova, Dmitry M. Hushpulian, Rachel E. Speer, Irina N. Gaisina, Rajiv R. Ratan, Irina G. Gazaryan · 2012 · Biochemistry (Moscow)
23. Characterization of Ankyrin Repeat–Containing Proteins as Substrates of the Asparaginyl Hydroxylase Factor Inhibiting Hypoxia‐Inducible Transcription Factor
    Sarah Linke, Rachel J. Hampton‐Smith, Daniel J. Peet · 2007 · Methods in enzymology on CD-ROM/Methods in enzymology
24. Factor inhibiting hypoxia-inducible factor (FIH) and other asparaginyl hydroxylases
    David E. Lancaster, M.A. McDonough, Christopher John Schofield · 2004 · Biochemical Society Transactions
25. Monoclonal Antibody-Based Screening Assay for Factor Inhibiting Hypoxia-Inducible Factor Inhibitors
    Sang-Hyeup Lee, Jeong Hee Moon, Eun Ah Cho, Seong-Eon Ryu, Myung Kyu Lee · 2008 · SLAS DISCOVERY
26. 1,2,3,4,6-Penta-O-galloly-beta-D-glucose Suppresses Hypoxia-Induced Accumulation of Hypoxia-Inducible Factor-1.ALPHA. and Signaling in LNCaP Prostate Cancer Cells
    Ki-Young Park, Hyo‐Jeong Lee, Soo‐Jin Jeong, Hyo‐Jung Lee, Hyun‐Seok Kim, Sun‐Hyung Kim, Sabina Lim, Ho-Cheol Kim, Junxuan Lü, Sung‐Hoon Kim · 2010 · Biological and Pharmaceutical Bulletin
27. Understanding complexity in the HIF signaling pathway using systems biology and mathematical modeling
    Zsolt Fábián, Cormac T. Taylor, Lan K. Nguyen · 2016 · Journal of Molecular Medicine
28. HIF gene expression in cancer therapy
    Chan, Denise A., Krieg, Adam J., Turcotte, Sandra, Giaccia, Amato J. · 2007 · Methods in Enzymology
29. The JMJD Family Histone Demethylases in Crosstalk Between Inflammation and Cancer
    Jia Yang, Yuan Hu, Binjing Zhang, Xiao Liang, Xin Li · 2022 · Frontiers in Immunology
30. Inverse Solvent Isotope Effects Arising from Substrate Triggering in the Factor Inhibiting Hypoxia Inducible Factor
    John A. Hangasky, Evren Saban, Michael J. Knapp · 2013 · Biochemistry
31. Upregulation of miR-184 Enhances the Malignant Biological Behavior of Human Glioma Cell Line A172 by Targeting FIH-1
    Qinghua Yuan, Weida Gao, Bo Liu, Wei Ye · 2014 · Cellular Physiology and Biochemistry
32. AK-1, a SIRT2 inhibitor, destabilizes HIF-1α and diminishes its transcriptional activity during hypoxia
    So Dam Lee, Wootae Kim, Joo‐Won Jeong, Jong‐Wan Park, Ja‐Eun Kim · 2016 · Cancer Letters
33. Inhibitors of both the N -methyl lysyl- and arginyl-demethylase activities of the JmjC oxygenases
    Joanna Bonnici, Anthony Tumber, Akane Kawamura, Christopher John Schofield · 2018 · Philosophical Transactions of the Royal Society B Biological Sciences
34. The strict regulation of HIF-1α by non-coding RNAs: new insight towards proliferation, metastasis, and therapeutic resistance strategies
    Sabrean Farhan Jawad, Farag M. A. Altalbawy, Radhwan Mohammed Hussein, Ali Abdulhussain Fadhil, Mohammed Abed Jawad, Rahman Sahib Zabibah, Tasneem Younus Taraki, Chakrabhavi Dhananjaya Mohan, Kanchugarakoppal Subbegowda Rangappa · 2023 · Cancer and Metastasis Reviews
35. Rhapontigenin Inhibited Hypoxia Inducible Factor 1 Alpha Accumulation and Angiogenesis in Hypoxic PC-3 Prostate Cancer Cells
    Deok‐Beom Jung, Hyo‐Jeong Lee, Soo‐Jin Jeong, Hyo‐Jung Lee, Eun‐Ok Lee, Young Chul Kim, Kyoo Seok Ahn, Changyan Chen, Sung‐Hoon Kim · 2011 · Biological and Pharmaceutical Bulletin
36. Role of HIF ‐1α in pathogenic mechanisms of keloids
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37. Interaction of HIF-1 and Notch3 Is Required for the Expression of Carbonic Anhydrase 9 in Breast Carcinoma Cells
    Mohammed M. Shareef, T.S. Udayakumar, V. K. Sinha, S. M. Saleem, Wendy W. Griggs · 2013 · Genes & Cancer
38. Oxygen-Dependent Asparagine Hydroxylation
    Daniel J. Peet, David Lando, Dean A. Whelan, Murray L. Whitelaw, Jeffrey John Gorman · 2004 · Methods in enzymology on CD-ROM/Methods in enzymology
39. Oxygen sensors as therapeutic targets in kidney disease
    Volker H. Haase · 2017 · Néphrologie & Thérapeutique
40. Biochemical and biophysical analyses of hypoxia sensing prolyl hydroxylases from Dictyostelium discoideum and Toxoplasma gondii
    Tongri Liu, Martine I. Abboud, Rasheduzzaman Chowdhury, Anthony Tumber, A. Hardy, Kerstin Lippl, Christopher T. Lohans, Elisabete Pires, James R. Wickens, M.A. McDonough et al. · 2020 · Journal of Biological Chemistry
41. The Rate-Limiting Step of O2 Activation in the α-Ketoglutarate Oxygenase Factor Inhibiting Hypoxia Inducible Factor
    John A. Hangasky, Hasand Gandhi, Meaghan A. Valliere, Nathaniel E. Ostrom, Michael J. Knapp · 2014 · Biochemistry
42. Biological Outer-Sphere Coordination
    Kyle M. Lancaster · 2011 · Structure and bonding
43. An Oxygen Molecular Sensor, the HIF Prolyl 4-Hydroxylase, in the Marine Protist Perkinsus olseni
    Ricardo B. Leite, Anabela Bensimon‐Brito, M. Leonor Cancela · 2008 · Protist
44. Protein Kinase C-Mediated Modulation of FIH-1 Expression by the Homeodomain Protein CDP/Cut/Cux
    Jin‐Ping Li, Enfeng Wang, Shamit Kumar Dutta, Julie S. Lau, Shi‐Wen Jiang, Kaustubh Datta, Debabrata Mukhopadhyay · 2007 · Molecular and Cellular Biology
45. Oxygen Sensing: Getting Pumped by Sterols
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46. The multifaceted functions of RNA helicases in the adaptive cellular response to hypoxia: From mechanisms to therapeutics
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47. Uncoupled O2-activation in the human HIF-asparaginyl hydroxylase, FIH, does not produce reactive oxygen species
    Evren Saban, Shannon C. Flagg, Michael J. Knapp · 2011 · Journal of Inorganic Biochemistry
48. Current advances in the novel functions of hypoxia‐inducible factor and prolyl hydroxylase in invertebrates
    Lingmiao Wang, Sufen Cui, Lina Ma, Lingxin Kong, Xueqing Geng · 2015 · Insect Molecular Biology
49. Structural basis for binding of the renal carcinoma target hypoxia‐inducible factor 2α to prolyl hydroxylase domain 2
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50. Factor-inhibiting HIF (FIH) promotes lung cancer progression
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51. The zebrafish miR-125c is induced under hypoxic stress via hypoxia-inducible factor 1α and functions in cellular adaptations and embryogenesis
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52. Molecular regulation of hypoxia through the lenses of noncoding RNAs and epitranscriptome
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53. Lessons from Comparison of Hypoxia Signaling in Plants and Mammals
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54. Novel Erythropoietic Agents: A Threat to Sportsmanship
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55. Impact of maternal protein restriction on Hypoxia-Inducible Factor (HIF) expression in male fetal kidney development
    Julia Sevá Gomes, Letícia de Barros Sene, Gabriela Leme Lamana, Patrícia Aline Boer, José Antônio Rocha Gontijo · 2023 · PLoS ONE
56. The Role of 2-Oxoglutarate-Dependent Oxygenases in Hypoxia Sensing
    Sarah E. Wilkins, Emily Flashman, John S. Scotti, Richard J. Hopkinson, Rasheduzzaman Chowdhury, Christopher John Schofield · 2015 · Royal Society of Chemistry eBooks
57. Nuclear entry and export of FIH are mediated by HIF1α and exportin1, respectively
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58. Engineering Tools for Regulating Hypoxia in Tumour Models
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59. Investigations on the role of a solvent tunnel in the α-ketoglutarate dependent oxygenase factor inhibiting HIF (FIH)
    Vanessa D. Chaplin, Meaghan A. Valliere, John A. Hangasky, Michael J. Knapp · 2017 · Journal of Inorganic Biochemistry
60. Increased hypoxia-inducible factor 1α expression in lung cells of horses with recurrent airway obstruction
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61. Featured Article: Hypoxia-inducible factor-1α dependent nuclear entry of factor inhibiting HIF-1
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62. Factor inhibiting HIF can catalyze two asparaginyl hydroxylations in VNVN motifs of ankyrin fold proteins
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63. Structure and Function of the CBP/p300 TAZ Domains
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65. Oxygen sensing in cancer
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66. Erythropoietic Factors
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67. Regulation of Cancer‐Associated miRNAs Expression under Hypoxic Conditions
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68. Human prolyl hydroxylase domain 2 reacts with O2 and 2-oxoglutarate to enable formation of inactive Fe(III).2OG.hypoxia-inducible-factor α complexes
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69. Substrate Positioning by Gln239 Stimulates Turnover in Factor Inhibiting HIF, an αKG-Dependent Hydroxylase
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70. Studies on the Substrate Selectivity of the Hypoxia‐Inducible Factor Prolyl Hydroxylase 2 Catalytic Domain
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71. Targeting Tumor Hypoxia
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72. Discovery of ZG-2305, an Orally Bioavailable Factor Inhibiting HIF Inhibitor for the Treatment of Obesity and Fatty Liver Disease
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74. Biopharmaceuticals: Post‐Translational Modification Carboxylation and Hydroxylation
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75. Methods for production and assaying catalysis of isolated recombinant human aspartate/asparagine-β-hydroxylase
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76. Role of Sodium‐Dependent Vitamin C Transporter‐2 and Ascorbate in Regulating the Hypoxic Pathway in Cultured Glioblastoma Cells
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77. Human activated macrophages and hypoxia: a comprehensive review of the literature.
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78. Tankyrases modulate the hypoxia response through non-catalytic mechanisms affecting HIF-1α
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79. Structural and functional consequences of aspartate/asparagine-β-hydroxylase variants causing Traboulsi syndrome
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80. Molecular characterization and function of hif1a and fih1 in response to acute thermal stress in American shad (Alosa sapidissima)
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81. The Signaling Nature of Cellular Metabolism: The Hypoxia Signaling
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82. Biochemical and Structural Insights into FIH‐Catalysed Hydroxylation of Transient Receptor Potential Ankyrin Repeat Domains
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83. Therapeutic Strategies that Target the HIF System
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84. Oxygenases for oxygen sensing
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85. Novel Dioxygenases, HIF-α Specific Prolyl-hydroxylase and Asparanginyl-hydroxylase: O2 Switch for Cell Survival
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86. Dysfunction of Mitochondrial ATP Production As a Target for Personalized Cancer Therapy
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87. Expression and Roles of Individual HIF Prolyl 4-Hydroxylase Isoenzymes in the Regulation of the Hypoxia Response Pathway along the Murine Gastrointestinal Epithelium
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88. Mechanisms and triggers of adaptation to hypoxia
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89. The role of hypoxia-inducible factor-1α in COPD
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90. CHARACTERIZATION OF THE NOVEL HUMAN PROLYL 4-HYDROXYLASES AND ASPARAGINYL HYDROXYLASE THAT MODIFY THE HYPOXIA- INDUCIBLE FACTOR
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91. Hypoxia in Drug Resistance and Radioresistance
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92. Hypoxic Response and Associated Diseases
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93. Controlled Oxygen Activation in Human Oxygen Sensor FIH
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94. Interplay between hypoxia and gastrin in gastrointestinal cancer
    E.L. Royal · 2009 · Nottingham ePrints (University of Nottingham)
95. Genetic studies of familial myeloproliferative disorders
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96. Selective Inhibition and Mechanistic Studies of the Human O2 Sensor, Prolyl Hydroxylase Domain 2 (PHD2)
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97. Hypoxia and differentiation in human neuroblastoma cells
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98. Involvement of Intracellular Reactive Oxygen Species in the Control of Gene Expression by Oxygen
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99. Promotor engineering in Saccharomyces cerevisiae for transcriptional control under different physiological conditions
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100. Subcellular localization of hypoxia-inducible factors and HIF regulatory hydroxylases in rat liver.
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