Hypoxia-inducible factor asparaginyl hydroxylase (FIH-1) catalyses hydroxylation at the β-carbon of asparagine-803

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

Wang, G. L., Jiang, B. H., Rue, E. A., & Semenza, G. L. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.12.5510 · Cited by 6,212

Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O 2 -Regulated Prolyl Hydroxylation

Jaakkola, P., Mole, D. R., Tian, Y.-M., Wilson, M. I., Gielbert, J., Gaskell, S. J., Kriegsheim, A. V., Hebestreit, H. F., Mukherji, M., Schofield, C. J., et al. (2001) · Science · doi:10.1126/science.1059796 · Cited by 5,535

HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O 2 Sensing

Ivan, M., Kondo, K., Yang, H., Kim, W., Valiando, J., Ohh, M., Salic, A., Asara, J. M., Lane, W. S., & Kaelin Jr., W. G. (2001) · Science · doi:10.1126/science.1059817 · Cited by 4,735

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

Epstein, A. C. R., Gleadle, J. M., McNeill, L. A., Hewitson, K. S., O'Rourke, J., Mole, D. R., Mukherji, M., Metzen, E., Wilson, M. I., Dhanda, A., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00507-4 · Cited by 3,333

A conserved family of prolyl-4-hydroxylases that modify HIF

Bruick, R. K., & McKnight, S. L. (2001) · Science · doi:10.1126/science.1066373 · Cited by 2,549

Regulation of Mammalian O 2 Homeostasis by Hypoxia-Inducible Factor 1

Semenza, G. L. (1999) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.15.1.551 · Cited by 1,914

Asparagine Hydroxylation of the HIF Transactivation Domain: A Hypoxic Switch

Lando, D., Peet, D. J., Whelan, D. A., Gorman, J. J., & Whitelaw, M. L. (2002) · Science · doi:10.1126/science.1068592 · Cited by 1,558

FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

Lando, D., Peet, D. J., Gorman, J. J., Whelan, D. A., Whitelaw, M. L., & Bruick, R. K. (2002) · Genes & Development · doi:10.1101/gad.991402 · Cited by 1,550

FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity

Mahon, P. C., Hirota, K., & Semenza, G. L. (2001) · Genes & Development · doi:10.1101/gad.924501 · Cited by 1,385

Kruppel-Like Factor 15 Modulates Renal Interstitial Fibrosis by ERK/MAPK and JNK/MAPK Pathways Regulation

Gao, X., Wu, G., Gu, X., Fu, L., & Mei, C. (2013) · Kidney & Blood Pressure Research · doi:10.1159/000355743 · Cited by 1,035

Independent function of two destruction domains in hypoxia-inducible factor-α chains activated by prolyl hydroxylation

Masson, N., Willam, C., Maxwell, P. H., Pugh, C. W., & Ratcliffe, P. J. (2001) · The EMBO Journal · doi:10.1093/emboj/20.18.5197 · Cited by 1,014

HIF-1α binding to VHL is regulated by stimulus-sensitive proline hydroxylation

Yu, F., White, S. B., Zhao, Q., & Lee, F. S. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.181341498 · Cited by 796

Structure of an HIF-1α-pVHL Complex: Hydroxyproline Recognition in Signaling

Min, J.-H., Yang, H., Ivan, M., Gertler, F., Kaelin, W. G., & Pavletich, N. P. (2002) · Science · doi:10.1126/science.1073440 · Cited by 765

Structural basis for the recognition of hydroxyproline in HIF-1α by pVHL

Hon, W.-C., Wilson, M. I., Harlos, K., Claridge, T. D. W., Schofield, C. J., Pugh, C. W., Maxwell, P. H., Ratcliffe, P. J., Stuart, D. I., & Jones, E. Y. (2002) · Nature · doi:10.1038/nature00767 · Cited by 751

Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family

Hewitson, K. S., McNeill, L. A., Riordan, M. V., Tian, Y.-M., Bullock, A. N., Welford, R. W., Elkins, J. M., Oldham, N. J., Bhattacharya, S., Gleadle, J. M., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.c200273200 · Cited by 719

Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1α

Freedman, S. J., Sun, Z., Poy, F., Kung, A. L., Livingston, D. M., Wagner, G., & Eck, M. J. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.082117899 · Cited by 457

Structural basis for Hif-1α/CBP recognition in the cellular hypoxic response

Dames, S. A., Martinez‐Yamout, M. A., Guzman, R. N. D., Dyson, H. J., & Wright, P. E. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.082121399 · Cited by 404

Biomolecular NMR spectroscopy

(1996) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(96)90069-5 · Cited by 325

Structure-function relationships of epidermal growth factor modules in vitamin K-dependent clotting factors

Stenflo, J. (1991) · Blood · doi:10.1182/blood.v78.7.1637.1637 · Cited by 159

Overexpression of human aspartyl(asparaginyl)beta-hydroxylase in hepatocellular carcinoma and cholangiocarcinoma.

Lavaissière, L., Jia, S., Nishiyama, M., de la Monte, S. M., Stern, A. M., Wands, J. R., & Friedman, P. A. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118918 · Cited by 153

Hydroxylation of aspartic acid in domains homologous to the epidermal growth factor precursor is catalyzed by a 2-oxoglutarate-dependent dioxygenase.

Stenflo, J., Holme, E., Lindstedt, S., Chandramouli, N., Huang, L. H., Tam, J. P., & Merrifield, R. B. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.2.444 · Cited by 93

cDNA cloning and expression of bovine aspartyl (asparaginyl) beta-hydroxylase.

Jia, S., VanDusen, W. J., Diehl, R. E., Kohl, N. E., Dixon, R. A., Elliston, K. O., Stern, A. M., & Friedman, P. A. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)49715-9 · Cited by 89

Occurrence of beta-hydroxylated asparagine residues in non-vitamin K-dependent proteins containing epidermal growth factor-like domains.

Przysiecki, C. T., Staggers, J. E., Ramjit, H. G., Musson, D. G., Stern, A. M., Bennett, C. D., & Friedman, P. A. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.22.7856 · Cited by 79

Partial purification and characterization of bovine liver aspartyl beta-hydroxylase.

Gronke, R. S., Welsch, D., VanDusen, W. J., Garsky, V. M., Sardana, M. K., Stern, A. M., & Friedman, P. A. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)38924-0 · Cited by 51

Asymmetric Synthesis of Orthogonally Protected l -threo-β-Hydroxyasparagine

Boger, D. L., Lee, R. J., Bounaud, P., & Meier, P. J. (2000) · The Journal of Organic Chemistry · doi:10.1021/jo000628s · Cited by 47

A Model for the Complex Between the Hypoxia-Inducible Factor-1 (HIF-1) and its Consensus DNA Sequence

Michel, G., Minet, E., Ernest, I., Roland, I., Durant, F., Remacle, J., & Michiels, C. (2000) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2000.10506656 · Cited by 35

Proton NMR assignment and secondary structure of the calcium-free form of the amino-terminal epidermal growth factor like domain in coagulation factor X

Selander, M., Persson, E., Stenflo, J., & Drakenberg, T. (1990) · Biochemistry · doi:10.1021/bi00487a018 · Cited by 30

Synthesis of carumonam (AMA-1080) and a related compound starting from (2R,3R)-epoxysuccinic acid.

SENDAI, M., Hashiguchi, S., TOMIMOTO, M., KISHIMOTO, S., Matsuo, T., & Ochiai, M. (1985) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.33.3798 · Cited by 22

Structure-function relationships of epidermal growth factor modules in vitamin K-dependent clotting factors

Stenflo, J. (1991) · Blood · doi:10.1182/blood.v78.7.1637.bloodjournal7871637

Synthesis of 3-Hydroxylated Analogues of D-Aspartic Acid β-Hydroxamate

Charvillon, F. B., & Amouroux, R. (1997) · Synthetic Communications · doi:10.1080/00397919708006039

Specific cleavage of peptides containing an aspartic acid (.beta.-hydroxamic acid) residue

Blodgett, J. K., Loudon, G. M., & Collins, K. D. (1985) · Journal of the American Chemical Society · doi:10.1021/ja00300a039

Oxygen sensing by HIF hydroxylases

Schofield, C. J., & Ratcliffe, P. J. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1366 · Cited by 2,068

HIF-1α pathway: role, regulation and intervention for cancer therapy

Masoud, G. N., & Li, W. (2015) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2015.05.007 · Cited by 1,871

Protein Posttranslational Modifications: The Chemistry of Proteome Diversifications

Walsh, C. T., Garneau‐Tsodikova, S., & Gatto, G. J. J. (2005) · Angewandte Chemie International Edition · doi:10.1002/anie.200501023 · Cited by 1,654

Differential Roles of Hypoxia-Inducible Factor 1α (HIF-1α) and HIF-2α in Hypoxic Gene Regulation

Hu, C.-J., Wang, L.-Y., Chodosh, L. A., Keith, B., & Simon, M. C. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.24.9361-9374.2003 · Cited by 1,386

HIF prolyl‐hydroxylase 2 is the key oxygen sensor setting low steady‐state levels of HIF‐1α in normoxia

Berra, E., Benizri, E., Ginouvès, A., Volmat, V., Roux, D., & Pouysségur, J. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg392 · Cited by 1,348

Substrate Requirements of the Oxygen-sensing Asparaginyl Hydroxylase Factor-inhibiting Hypoxia-inducible Factor

Linke, S., Stojkoski, C., Kewley, R. J., Booker, G. W., Whitelaw, M. L., & Peet, D. J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313614200 · Cited by 79

Auto-hydroxylation of FIH-1: an Fe(ii), α-ketoglutarate-dependent human hypoxia sensor

Chen, Y.-H., Comeaux, L. M., Eyles, S. J., & Knapp, M. J. (2008) · Chemical Communications · doi:10.1039/b809099h · Cited by 38

Factor inhibiting hypoxia-inducible factor (FIH) and other asparaginyl hydroxylases

Lancaster, D. E., McDonough, M. A., & Schofield, C. J. (2004) · Biochemical Society Transactions · doi:10.1042/bst0320943 · Cited by 30

Structure of factor-inhibiting hypoxia-inducible factor 1: an asparaginyl hydroxylase involved in the hypoxic response pathway

Dann, C. E., Bruick, R. K., & Deisenhofer, J. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.202614999 · Cited by 200

Structure of Factor-inhibiting Hypoxia-inducible Factor (HIF) Reveals Mechanism of Oxidative Modification of HIF-1α

Elkins, J. M., Hewitson, K. S., McNeill, L. A., Seibel, J. F., Schlemminger, I., Pugh, C. W., Ratcliffe, P. J., & Schofield, C. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.c200644200 · Cited by 391