The specificities of protein kinase inhibitors: an update

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1. Discovery of potent small molecule inhibitors of DYRK1A by structure-based virtual screening and bioassay
   Di Wang, Fei Wang, Yexiong Tan, Liwei Dong, Lei Chen, Weiliang Zhu, Hongyang Wang · 2011 · Bioorganic & Medicinal Chemistry Letters
2. Constitutive Activity of JNK2α2 Is Dependent on a Unique Mechanism of MAPK Activation
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3. Stress-Induced Enzyme Activation Primes Murine Embryonic Stem Cells to Differentiate Toward the First Extraembryonic Lineage
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4. Epidermal growth factor induces adult human islet cell dedifferentiation
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5. A Phenotypic Screen in Zebrafish Identifies a Novel Small-Molecule Inducer of Ectopic Tail Formation Suggestive of Alterations in Non-Canonical Wnt/PCP Signaling
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6. Peptides as Signaling Inhibitors for Mammalian MAP Kinase Cascades
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7. Transforming Growth Factor β Is a Critical Regulator of Adult Human Islet Plasticity
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8. Induction of ANGPTL4 expression in human airway smooth muscle cells by PMA through activation of PKC and MAPK pathways
   Cliona M. Stapleton, Joung Hyuck Joo, Yong-Sik Kim, Grace Liao, Reynold A. Panettieri, Anton M. Jetten · 2009 · Experimental Cell Research
9. MAPK inhibitors augment gallic acid-induced A549 lung cancer cell death through the enhancement of glutathione depletion
   Woo Hyun Park, Suhn Hee Kim · 2013 · Oncology Reports
10. Glycogen Synthase Kinase-3β Inhibition Ameliorates Cardiac Parasympathetic Dysfunction in Type 1 Diabetic Akita Mice
    Yali Zhang, Charles M. Welzig, Kristen L. Picard, Chuang Du, Bo Wang, Jen Q. Pan, John M. Kyriakis, Mark J. Aronovitz, William C. Claycomb, Robert M. Blanton et al. · 2014 · Diabetes
11. The Ste20-like kinase SLK promotes p53 transactivation and apoptosis
    Andrey V. Cybulsky, Tomoko Takano, Julie Guillemette, Joan Papillon, Rildo Aparecido Volpini, John A. Di Battista · 2009 · American Journal of Physiology-Renal Physiology
12. Cellular stress increases RGS2 mRNA and decreases RGS4 mRNA levels in SH-SY5Y cells
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13. Serotonin (5-HT) Transport in Human Platelets is Modulated by Src-Catalysed Tyr-Phosphorylation of the Plasma Membrane Transporter SERT
    Alessandro Zarpellon, Arianna Donella‐Deana, Alessandra Folda, Loris Turetta, Martina Pavanetto, Renzo Deana · 2008 · Cellular Physiology and Biochemistry
14. Reverse Two-hybrid Screening Identifies Residues of JNK Required for Interaction with the Kinase Interaction Motif of JNK-interacting Protein-1
    Renae K. Barr, Richard M. Hopkins, Paul M. Watt, Marie A. Bogoyevitch · 2004 · Journal of Biological Chemistry
15. Prolactin Enhances Insulin-like Growth Factor I Receptor Phosphorylation by Decreasing Its Association with the Tyrosine Phosphatase SHP-2 in MCF-7 Breast Cancer Cells
    Kristopher C. Carver, Timothy M. Piazza, Linda A. Schuler · 2010 · Journal of Biological Chemistry
16. A high-performance liquid chromatography assay for Dyrk1a, a Down syndrome-associated kinase
    Linh Chi Bui, Laure Tabouy, Florent Busi, Jean‐Marie Dupret, Nathalie Janel, Chris Planque, Jean Maurice Delabar, Fernando Rodrigues‐Lima, Julien Dairou · 2013 · Analytical Biochemistry
17. The Src kinases Hck, Fgr, and Lyn activate Abl2/Arg to facilitate IgG-mediated phagocytosis and Leishmania infection
    Dawn M. Wetzel, Emma L. Rhodes, Shaoguang Li, Diane McMahon‐Pratt, Anthony J. Koleske · 2016 · Journal of Cell Science
18. Epigallocatechin gallate is a potent inhibitor of cystathionine beta-synthase: Structure-activity relationship and mechanism of action
    Karim Zuhra, Maria Petrosino, Barkha Gupta, Theodora Panagaki, Marco Cecconi, Vassilios Myrianthopoulos, Roger Schneiter, Emmanuel Mikros, Tomáš Majtán, Csaba Szabó · 2022 · Nitric Oxide
19. The Effect of the JNK Inhibitor, JIP Peptide, on Human T Lymphocyte Proliferation and Cytokine Production
    Michelle Melino, Charles S T Hii, Shaun R. McColl, Antonio Ferrante · 2008 · The Journal of Immunology
20. Protein phosphatase 1α is tyrosine-phosphorylated and inactivated by peroxynitrite in erythrocytes through the src family kinase fgr
    Cinzia Mallozzi, Lucia De Franceschi, Carlo Brugnara, Anna Maria Michela Di Stasi · 2005 · Free Radical Biology and Medicine
21. Distinct functions of JNK and c‐Jun in oxidant‐induced hepatocyte death
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22. Synthesis and Evaluation of 3‐Phenylpyrazolo[3,4‐ d ]pyrimidine‐Peptide Conjugates as Src Kinase Inhibitors
    Anil Kumar, Yuehao Wang, Xiaofeng Lin, Gongqin Sun, Keykavous Parang · 2007 · ChemMedChem
23. Different Head Environments in Tarantula Thick Filaments Support a Cooperative Activation Process
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24. Vg1RBP phosphorylation by Erk2 MAP kinase correlates with the cortical release of Vg1 mRNA during meiotic maturation of Xenopus oocytes
    Anna Git, Rachel J. Allison, Eusebio Perdiguero, Ángel R. Nebreda, Evelyn Houliston, Nancy Standart · 2009 · RNA
25. Differing mechanisms of cAMP‐ versus seawater‐induced oocyte maturation in marine nemertean worms I. The roles of serine/threonine kinases and phosphatases
    Stephen A. Stricker, Toni L. Smythe · 2006 · Molecular Reproduction and Development
26. Protein Arginine Methyltransferase 6 (Prmt6) Is Essential for Early Zebrafish Development through the Direct Suppression of gadd45αa Stress Sensor Gene
    Xinxi Zhao, Yunbin Zhang, Pei-Li Ni, Zhili Wu, Yuanchang Yan, Yiping Li · 2015 · Journal of Biological Chemistry
27. Extracellular Signal-Regulated Protein Kinase, c-Jun N-Terminal Protein Kinase, and Calcineurin Regulate Transient Receptor Potential M3 (TRPM3) Induced Activation of AP-1
    Andrea Lesch, Oliver G. Rößler, Gerald Thiel · 2017 · Journal of Cellular Biochemistry
28. Comparative Binding Energy Analysis Considering Multiple Receptors: A Step toward 3D-QSAR Models for Multiple Targets
    Marta Murcia, Antonio Morreale, Ángel R. Ortíz · 2006 · Journal of Medicinal Chemistry
29. Cyclin-dependent kinase 1 (CDK1) and CDK2 have opposing roles in regulating interactions of splicing factor 3B1 with chromatin
    Tushar Murthy, Theresa Bluemn, Abhishek Kumar Gupta, Michael H. Reimer, Sridhar Rao, Manoj M. Pillai, Alex C. Minella · 2018 · Journal of Biological Chemistry
30. Nuclear trapping of inactive FOXO1 by the Nrf2 activator diethyl maleate
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31. Rho-associated kinase and zipper-interacting protein kinase, but not myosin light chain kinase, are involved in the regulation of myosin phosphorylation in serum-stimulated human arterial smooth muscle cells
    Jingti Deng, Sabreena Bhaidani, Cindy Sutherland, Justin A. MacDonald, Michael P. Walsh · 2019 · PLoS ONE
32. The Rho‐GTPase effector ROCK regulates meiotic maturation of the bovine oocyte via myosin light chain phosphorylation and cofilin phosphorylation
    So‐Rim Lee, Yong‐Nan Xu, Yu‐Jin Jo, Suk Namgoong, Nam‐Hyung Kim · 2015 · Molecular Reproduction and Development
33. Prediction of Specificity and Cross-Reactivity of Kinase Inhibitors
    Nitish K. Mishra, Gajendra P. S. Raghava · 2011 · Letters in Drug Design & Discovery
34. Anti-angiogenic potential of small molecular inhibitors of cyclin dependent kinases in vitro
    Stefan Zahler A, Johanna Liebl, Robert Fürst, Angelika M. Vollmar · 2010 · Angiogenesis
35. CDK inhibitors suppress Th17 and promote iTreg differentiation, and ameliorate experimental autoimmune encephalomyelitis in mice
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36. Sphingosine-1-phosphate-induced ERK activation protects human melanocytes from UVB-induced apoptosis
    Dong-Seok Kim, Sook-Young Kim, Jai-Eun Lee, Sun-Bang Kwon, Young-Hyun Joo, Sang Woong Youn, Kyoung-Chan Park · 2003 · Archives of Pharmacal Research
37. Protein kinase C activation stabilizes LDL receptor mRNA via the JNK pathway in HepG2 cells
    Noelle B. Vargas, Brandy Y. Brewer, Terry B. Rogers, Gerald M. Wilson · 2008 · Journal of Lipid Research
38. Phosphorylation of Hepatitis C Virus RNA Polymerases Ser29 and Ser42 by Protein Kinase C-Related Kinase 2 Regulates Viral RNA Replication
    Song-Hee Han, Seong-Jun Kim, Eun‐Jung Kim, Tae-Eun Kim, Jae-Su Moon, Geon‐Woo Kim, Seung‐Hoon Lee, Kun Cho, Jong Shin Yoo, Woo Sung Son et al. · 2014 · Journal of Virology
39. Pharmacological characterization of a small molecule inhibitor of c-Jun kinase
    Helen K. Cho, Shawn C. Black, David Looper, Manli Shi, Dawn Kelly-Sullivan, Sergei L. Timofeevski, Karen Siegel, Xiaohong Yu, Scott R. P. McDonnell, Ping Chen et al. · 2008 · American Journal of Physiology-Endocrinology and Metabolism
40. Temporal change in local forces and total force all over the surface of the sea urchin egg during cytokinesis
    Hiromi Miyoshi, Setsuko K. Satoh, Eio Yamada, Yukihisa Hamaguchi · 2006 · Cell Motility and the Cytoskeleton
41. Abrupt Reoxygenation of Microvascular Endothelial Cells After Hypoxia Activates ERK1/2 and JNK1, Leading to NADPH Oxidase‐Dependent Oxidant Production
    GUO YU, Tianqing Peng, Qingping Feng, Karel Tyml · 2007 · Microcirculation
42. A novel inhibitory effect of oxazol-5-one compounds on ROCKII signaling in human coronary artery vascular smooth muscle cells
    Abdulhameed Al‐Ghabkari, Jingti Deng, Paul C. McDonald, Shoukat Dedhar, Mana M. Alshehri, Michael P. Walsh, Justin A. MacDonald · 2016 · Scientific Reports
43. Proposed Allosteric Inhibitors Bind to the ATP Site of CK2α
    P. Brear, Darby Ball, Katherine M. Stott, Sheena D’Arcy, Marko Hyvönen · 2020 · Journal of Medicinal Chemistry
44. Activation of tissue plasminogen activator gene transcription by Neovastat, a multifunctional antiangiogenic agent
    Denis Gingras, Carine Nyalendo, Geneviève Di Tomasso, Borhane Annabi, Richard Béliveau · 2004 · Biochemical and Biophysical Research Communications
45. Immunomodulation of human B cells following treatment with intravenous immunoglobulins involves increased phosphorylation of extracellular signal-regulated kinases 1 and 2
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46. In silico profiling of tyrosine kinases binding specificity and drug resistance using Monte Carlo simulations with the ensembles of protein kinase crystal structures
    Gennady M. Verkhivker · 2006 · Biopolymers
47. c-Jun N-terminal kinase signaling regulates events associated with both health and degeneration in motoneurons
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48. Indomethacin and ibuprofen induce Hsc70 nuclear localization and activation of the heat shock response in HeLa cells
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49. Oxidative stress-driven mechanisms of nordihydroguaiaretic acid-induced apoptosis in FL5.12 cells
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50. Staurosporine tethered peptide ligands that target cAMP-dependent protein kinase (PKA): Optimization and selectivity profiling
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51. Differential Function of PTPα and PTPα Y789F in T Cells and Regulation of PTPα Phosphorylation at Tyr-789 by CD45
    Lola Maksumova, Yanni Wang, Nelson K.Y. Wong, Hoa Le, Catherine J. Pallen, Pauline Johnson · 2007 · Journal of Biological Chemistry
52. A novel inhibitor of active protein kinase G attenuates chronic inflammatory and osteoarthritic pain
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53. Increased dosage and treatment time of Epigallocatechin-3-gallate (EGCG) negatively affects skeletal parameters in normal mice and Down syndrome mouse models
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54. Inhibition of adrenergic human prostate smooth muscle contraction by the inhibitors of c‐Jun N‐terminal kinase, SP600125 and BI‐78D3
    Frank Strittmatter, Sebastian Walther, Christian Gratzke, Johanna Göttinger, Christer Beckmann, Alexander Roosen, Boris Schlenker, Petter Hedlund, Andersson Ke, C.G. Stief et al. · 2012 · British Journal of Pharmacology
55. Luciferin and derivatives as a DYRK selective scaffold for the design of protein kinase inhibitors
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56. Chemical approaches towards unravelling kinase-mediated signalling pathways
    David R. W. Hodgson, Martin Schröder · 2010 · Chemical Society Reviews
57. Electrochemical investigations of sarcoma-related protein kinase inhibition
    Sanela Martić, Mahmoud Labib, Heinz‐Bernhard Kraatz · 2011 · Electrochimica Acta
58. Recent advances in the discovery of Src kinase inhibitors
    Keykavous Parang, Gongqin Sun · 2005 · Expert Opinion on Therapeutic Patents
59. Extracellular Signal-Regulated Kinase Mitogen-Activated Protein Kinase-Dependent SOCS-3 Gene Induction Requires c-Jun, Signal Transducer and Activator of Transcription 3, and Specificity Protein 3 Transcription Factors
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60. Smooth muscle contraction and growth of stromal cells in the human prostate are both inhibited by the Src family kinase inhibitors, AZM475271 and PP2
    Yiming Wang, Christian Gratzke, Alexander J. Tamalunas, Beata Rutz, Anna Ciotkowska, Frank Strittmatter, Annika Herlemann, Sophie Janich, Raphaela M. Waidelich, Chunxiao Liu et al. · 2016 · British Journal of Pharmacology
61. IL-1β-Induced Downregulation of the Multifunctional PDZ Adaptor PDZK1 Is Attenuated by ERK Inhibition, RXRα, or PPARα Stimulation in Enterocytes
    Min Luo, Sunil Yeruva, Yongjian Liu, Giriprakash Chodisetti, Brigitte Riederer, M. Menon, Keisuke Tachibana, Takefumi Doi, Ursula Elisabeth Seidler · 2017 · Frontiers in Physiology
62. The Link of the Prion Protein with Ca2+ Metabolism and ROS Production, and the Possible Implication in Aβ Toxicity
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63. Synthesis, Biological Testing, and Binding Mode Prediction of 6,9-Diarylpurin-8-ones as p38 MAP Kinase Inhibitors
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64. Pharmacological evaluation of benzimidazole derivatives with potential antiviral and antitumor activity
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65. Therapies and rehabilitation in Down syndrome
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66. Inhibition of neddylation facilitates cell migration through enhanced phosphorylation of caveolin-1 in PC3 and U373MG cells
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67. Structure–Activity Relationships and Biological Evaluation of 7-Substituted Harmine Analogs for Human β-Cell Proliferation
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68. Alphaherpesvirus Latency and Reactivation with a Focus on Herpes Simplex Virus
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69. Fyn nanoclustering requires switching to an open conformation and is enhanced by FTLD-Tau biomolecular condensates
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70. Non-kinase targeting of oncogenic c-Jun N-terminal kinase (JNK) signaling: the future of clinically viable cancer treatments
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71. Seliciclib, a cell-cycle modulator that acts through the inhibition of cyclin-dependent kinases
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72. Expression of the Alternative Oxidase Influences Jun N-Terminal Kinase Signaling and Cell Migration
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73. Antibacterial activity of Barbatimão ( Stryphnodendron adstringens ) against Staphylococcus aureus : in vitro and in silico studies
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74. Perturbation biology links temporal protein changes to drug responses in a melanoma cell line
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75. Hydrogen Peroxide: The Good, The Bad, and The Ugly
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76. Tyrosine phosphorylation of the orphan receptor ESDN/DCBLD2 serves as a scaffold for the signaling adaptor CrkL
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77. Differing mechanisms of cAMP‐ versus seawater‐induced oocyte maturation in marine nemertean worms II. The roles of tyrosine kinases and phosphatases
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78. Investigating the neuroprotective mechanism of action of a CDK5 inhibitor by phosphoproteome analysis
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79. 15-Deoxy-Δ12,14-Prostaglandin J2 Inhibits IFN-Inducible Protein 10/CXC Chemokine Ligand 10 Expression in Human Microglia: Mechanisms and Implications
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80. Follicle Stimulating Hormone-Induced DNA Synthesis in the Granulosa Cells of Hamster Preantral Follicles Involves Activation of Cyclin-Dependent Kinase-4 Rather Than Cyclin D2 Synthesis1
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81. Kinase Targets and Inhibitors for the Treatment of Airway Inflammatory Diseases
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82. Regulation of a Myb Transcription Factor by Cyclin-dependent Kinase 2 in Giardia lamblia
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83. Roles of Src family kinase signaling during fertilization and the first cell cycle in the marine protostome worm Cerebratulus
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84. SP600125 inhibits Orthopoxviruses replication in a JNK1/2 -independent manner: Implication as a potential antipoxviral
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85. c-Jun N-Terminal Kinase Mediated VEGFR2 Sustained Phosphorylation is Critical for VEGFA-Induced Angiogenesis In Vitro and In Vivo
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86. Targeting inhibition of GluR1 Ser845 phosphorylation with an RNA aptamer that blocks AMPA receptor trafficking
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87. Matrix‐independent stimulation of human tubular epithelial cell migration by Rho kinase inhibitors
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88. Endoplasmic Reticulum Stress Increases the Expression of Methylenetetrahydrofolate Reductase through the IRE1 Transducer
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89. Rho kinase inhibitors for treatment of glaucoma
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90. Two specific drugs, BMS-345541 and purvalanol A induce apoptosis of HTLV-1 infected cells through inhibition of the NF-kappaB and cell cycle pathways
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91. Suppression of the lipopolysaccharide-induced expression of MARCKS-related protein (MRP) affects transmigration in activated RAW264.7 cells
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92. Organ- and Cell-Type Specific Delivery of Kinase Inhibitors: A Novel Approach in the Development of Targeted Drugs
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93. Auto‐reverse nuclear migration in bipolar mammalian cells on micropatterned surfaces
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94. Activation of Interferon Signaling in Chronic Lymphocytic Leukemia Cells Contributes to Apoptosis Resistance via a JAK-Src/STAT3/Mcl-1 Signaling Pathway
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95. Novel Mechanism for an Old Drug: Phenazopyridine is a Kinase Inhibitor Affecting Autophagy and Cellular Differentiation
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96. RSK1 vs. RSK2 Inhibitory Activity of the Marine β-Carboline Alkaloid Manzamine A: A Biochemical, Cervical Cancer Protein Expression, and Computational Study
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97. EGCG-like non-competitive inhibitor of DYRK1A rescues cognitive defect in a down syndrome model
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98. Inhibition of glycogen synthase kinase-3 enhances the differentiation and reduces the proliferation of adult human olfactory epithelium neural precursors
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99. Mutual effects of caveolin and nerve growth factor signaling in pig oligodendrocytes
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100. Design and evaluation of 3-aminopyrazolopyridinone kinase inhibitors inspired by the natural product indirubin
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