Cited by 542Cancer, Hypoxia, and MetabolismMitochondrial Function and PathologyRedox biology and oxidative stress

The DOI matches its Crossref record; 110 of the 113 references it cites were found in a registry or an index.

Oxygen-dependent regulation of mitochondrial respiration by hypoxia-inducible factor 1

Semenza, Gregg L.·2007·Biochemical Journal

DOI 10.1042/bj20070389

Open this paper in CoChat — free account

Abstract

The survival of metazoan organisms is dependent upon the utilization of O2 as a substrate for COX (cytochrome c oxidase), which constitutes Complex IV of the mitochondrial respiratory chain. Premature transfer of electrons, either at Complex I or at Complex III, results in the increased generation of ROS (reactive oxygen species). Recent studies have identified two critical adaptations that may function to prevent excessive ROS production in hypoxic cells. First, expression of PDK1 [PDH (pyruvate dehydrogenase) kinase 1] is induced. PDK1 phosphorylates and inactivates PDH, the mitochondrial enzyme that converts pyruvate into acetyl-CoA. In combination with the hypoxia-induced expression of LDHA (lactate dehydrogenase A), which converts pyruvate into lactate, PDK1 reduces the delivery of acetyl-CoA to the tricarboxylic acid cycle, thus reducing the levels of NADH and FADH2 delivered to the electron-transport chain. Secondly, the subunit composition of COX is altered in hypoxic cells by increased expression of the COX4-2 subunit, which optimizes COX activity under hypoxic conditions, and increased degradation of the COX4-1 subunit, which optimizes COX activity under aerobic conditions. Hypoxia-inducible factor 1 controls the metabolic adaptation of mammalian cells to hypoxia by activating transcription of the genes encoding PDK1, LDHA, COX4-2 and LON, a mitochondrial protease that is required for the degradation of COX4-1. COX subunit switching occurs in yeast, but by a completely different regulatory mechanism, suggesting that selection for O2-dependent homoeostatic regulation of mitochondrial respiration is ancient and likely to be shared by all eukaryotic organisms.

Integrity signals

Registry

Crossref · 10.1042/bj20070389

Cites

110 of 110 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O 2 -Regulated Prolyl Hydroxylation
Jaakkola, P., Mole, D. R., Tian, Y.-M., Wilson, M. I., Gielbert, J., Gaskell, S. J., Kriegsheim, A. V., Hebestreit, H. F., Mukherji, M., Schofield, C. J., et al. (2001) · Science · doi:10.1126/science.1059796 · Cited by 5,535
HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O 2 Sensing
Ivan, M., Kondo, K., Yang, H., Kim, W., Valiando, J., Ohh, M., Salic, A., Asara, J. M., Lane, W. S., & Kaelin Jr., W. G. (2001) · Science · doi:10.1126/science.1059817 · Cited by 4,735
Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
Forsythe, J. A., Jiang, B.-H., Iyer, N. V., Agani, F., Leung, S. W., Koos, R. D., & Semenza, G. L. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.9.4604 · Cited by 3,981
Self-citation
HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia
Kim, J.-W., Tchernyshyov, I., Semenza, G. L., & Dang, C. V. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.02.002 · Cited by 3,905
Self-citation
C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation
Epstein, A. C. R., Gleadle, J. M., McNeill, L. A., Hewitson, K. S., O'Rourke, J., Mole, D. R., Mukherji, M., Metzen, E., Wilson, M. I., Dhanda, A., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00507-4 · Cited by 3,333
A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation
Semenza, G. L., & Wang, G. L. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.12.5447 · Cited by 2,617
Self-citation
Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1
Ceradini, D. J., Kulkarni, A. R., Callaghan, M. J., Tepper, O. M., Bastidas, N., Kleinman, M. E., Capla, J. M., Galiano, R. D., Levine, J. P., & Gurtner, G. C. (2004) · Nature Medicine · doi:10.1038/nm1075 · Cited by 2,600
A conserved family of prolyl-4-hydroxylases that modify HIF
Bruick, R. K., & McKnight, S. L. (2001) · Science · doi:10.1126/science.1066373 · Cited by 2,549
Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
Carmeliet, P., Dor, Y., Herbert, J.-M., Fukumura, D., Brusselmans, K., Dewerchin, M., Neeman, M., Bono, F., Abramovitch, R., Maxwell, P., et al. (1998) · Nature · doi:10.1038/28867 · Cited by 2,502
Cellular and developmental control of O 2 homeostasis by hypoxia-inducible factor 1α
Iyer, N. V., Kotch, L. E., Agani, F., Leung, S. W., Laughner, E., Wenger, R. H., Gassmann, M., Gearhart, J. D., Lawler, A. M., Yu, A. Y., et al. (1998) · Genes & Development · doi:10.1101/gad.12.2.149 · Cited by 2,476
Self-citation

Show all 113 references

Sorted by citations

Items 401–500 of 542

Competitive HIF Prolyl Hydroxylase Inhibitors Show Protection against Oxidative Stress by a Mechanism Partially Dependent on Glycolysis
Bergström, A., Fog, K., Sager, T. N., Bruun, A. T., & Thirstrup, K. (2012) · ISRN Neuroscience · doi:10.1155/2013/598587 · Cited by 6
New fluorine-containing openers of ATP-sensitive potassium channels flokalin and tioflokalin inhibit calcium-induced mitochondrial pore opening in rat hearts [
Strutynska, N. A., Strutynskyi, R. B., Chorna, S. V., Semenykhina, O. M., Mys', L., Moibenko, O. O., & Sahach, V. F. (2014) · Fìzìologìčnij žurnal · doi:10.15407/fz59.06.003 · Cited by 6
Correction: Adaptation and Mal-Adaptation to Ambient Hypoxia; Andean, Ethiopian and Himalayan Patterns
Xing, G., Qualls, C., Huicho, L., Rivera, M. C., Stobdan, T., Slessarev, M., Prisman, E., Ito, S., Wu, H., Norboo, A., et al. (2008) · PLoS ONE · doi:10.1371/annotation/aba20dc1-b10d-464c-9671-c47b956d1718 · Cited by 6
Screening for the Metabolic Basis of Neurodegeneration
Murray, J. M., & Capaldi, R. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1427.025 · Cited by 6
Enzymes involved in hypoxia response : characterization of the in vivo role of HIF-P4H-2 in mouse heart, of a novel P4H in human and zebrafish and of the catalytic properties of FIH
Hyvärinen, J. (2010) · Cited by 6
A systematic review verified by bioinformatic analysis based on TCGA reveals week prognosis power of CAIX in renal cancer
Zhang, Z., Wu, B., Shao, Y., Chen, Y., & Wang, D. (2022) · PLoS ONE · doi:10.1371/journal.pone.0278556 · Cited by 5
Brain Metabolic Adaptations to Hypoxia
Puchowicz, M. A., Koppaka, S., & LaManna, J. C. (2008) · Springer eBooks · doi:10.1007/978-0-387-79112-8_2 · Cited by 5
Structural Insight into the Prolyl Hydroxylase PHD2: A Molecular Dynamics and DFT Study
Wick, C. R., Lanig, H., Jäger, C. M., Burzlaff, N. I., & Clark, T. (2012) · European Journal of Inorganic Chemistry · doi:10.1002/ejic.201200391 · Cited by 5
Papel del adipocito en la expresión del factor inducible por hipoxia (HIF) asociado a la obesidad
Reyes, H. J. N., Cortés, P., Cruz, A. G., Ugalde, M. C. N., Pizaña-Venegas, A., Jimenez, C. H., & RoblesI, R. R. (2011) · NCT Neumología y Cirugía de Tórax · Cited by 5
Oxidative Stress in Carcinogenesis and Therapy
Hatem, E., & Azzi, S. (2016) · Journal of Cell Signaling · doi:10.4172/2576-1471.1000102 · Cited by 5
Maternal physical activity prevents the overexpression of hypoxia-inducible factor 1-α and cardiorespiratory dysfunction in protein malnourished rats
Nogueira, V. O., Andrade, L. D. S., Rocha-Júnior, R. L., de Melo, P. E. D., Helvécio, E., Fontes, D. A. F., Romão, T. P., Leandro, C. G., & Costa‐Silva, J. H. (2019) · Scientific Reports · doi:10.1038/s41598-019-50967-7 · Cited by 5
α-Tocopherol Acetate Attenuates Mitochondrial Oxygen Consumption and Maintains Primitive Cells within Mesenchymal Stromal Cell Population
Loncaric, D., Rodríguez, L., Debeissat, C., Touya, N., Labat, V., Villacreces, A., Bouzier‐Sore, A., Pasquet, J., de la Grange, P. B., Vlaski‐Lafarge, M., et al. (2021) · Stem Cell Reviews and Reports · doi:10.1007/s12015-020-10111-9 · Cited by 8
Pathophysiologic and Anaesthetic Considerations in Iron Deficiency Anaemia and Pregnancy; An Update
Gupta, S., Sharma, K., Sharma, C., Chhabra, A., Jeengar, L., & Sharma, N. K. (2021) · Journal of Obstetric Anaesthesia and Critical Care · doi:10.4103/joacc.joacc_46_21 · Cited by 5
Natural hypoxic conditions do not affect the respiration rates of the cold-water coral Desmophyllum pertusum (Lophelia pertusa) living in the Angola margin (Southeastern Atlantic Ocean)
Gori, A., Orejas, C., Mienis, F., Ferrier‐Pagès, C., Bilan, M., Flöter, S., Reynaud, S., Sweetman, A. K., Roberts, J. M., Wienberg, C., et al. (2023) · Deep Sea Research Part I Oceanographic Research Papers · doi:10.1016/j.dsr.2023.104052 · Cited by 6
Interaction Between Hepatocytes and Proximal Tubular Epithelial Cells in Hypoxia-induced Lipotoxicity
Park, J., Heo, Y. J., & Kwon, S. (2021) · Biotechnology and Bioprocess Engineering · doi:10.1007/s12257-021-0137-7 · Cited by 5
Cytological characterization of Jatropha curcas callus in different periods of cultivation
dos Santos, D. N., Nunes, C. F., Soares, J. D. R., Valente, T. C. T., Alves, E., Labory, C. R. G., & Pasqual, M. (2013) · Crop Breeding and Applied Biotechnology · doi:10.1590/s1984-70332013000400002 · Cited by 5
Mitochondrial response of the lesser grain borer Rhyzopertha dominica (F.) to modified atmospheres
la Torre, V. A. L.-D., Cinco-Moroyoqui, F. J., López-Zavala, A. A., Wong‐Corral, F. J., & Martínez‐Cruz, O. (2019) · Journal of Stored Products Research · doi:10.1016/j.jspr.2019.08.005 · Cited by 5
Respiratory Insufficiency, the Retrograde Response, and the Origin of Cancer
Seyfried, T. N. (2012) · Wiley eBooks · doi:10.1002/9781118310311.ch10 · Cited by 5
Hypoxia-inducible factor prolyl 4-hydroxylase-2 in cardiac and skeletal muscle ischemia and metabolism
Karsikas, S. (2015) · Cited by 4
Experimental study of morphological changes in the heart and blood vessels in the course of chronic fluoride intoxication
Bugaeva, M. S., Бондарев, О. И., Yadykina, T. K., Жукова, А. Г., & Михайлова, Н. Н. (2023) · Hygiene and Sanitation · doi:10.47470/0016-9900-2023-102-4-397-401 · Cited by 4
Optic Fiber Microsensor Reveals Specific Spatiotemporal Oxygen Uptake Profiles at the Mammalian Ocular Surface
Sun, Q., Ma, L., Ferreira, F., Brown, C., Reid, B., & Zhao, M. (2023) · Biosensors · doi:10.3390/bios13020245 · Cited by 4
Expanding the understanding of Volvariella volvacea autolysis at 4°C with transcriptomics and metabolomics
Chang, T., Zha, L., Yu, C., Chen, M., Zhou, S., Dong, Q., Wu, Y., Fan, S., & Zhao, Y. (2024) · Scientia Horticulturae · doi:10.1016/j.scienta.2024.113386 · Cited by 4
Teratogenic effects of isolated and combined short-term hypercapnia and hypoxia on red sea bream (Pagrus major) embryos
Sawada, Y., Honryo, T., Agawa, Y., & Kurata, M. (2018) · Aquaculture Research · doi:10.1111/are.13781 · Cited by 4
Coenzyme Q10 and Fish Oil Supplementation for Reducing Retinal Oxidative Stress in a Rat Model
Siddiqui, F., Cai, C. L., Aranda, J. V., & Beharry, K. D. A. (2023) · Vision · doi:10.3390/vision7010020 · Cited by 4
Hypoxia-induced HIF-1α promotes Listeria monocytogenes invasion into tilapia
Wang, J., He, Z., Cui, M., Sun, J., Jiang, L., Zhuang, N., Zhu, F., Zhang, X., Song, H., & Cheng, C. (2023) · Microbiology Spectrum · doi:10.1128/spectrum.01405-23 · Cited by 4
Targeting Mitophagy in Combined Therapies of Haematological Malignancies
Kornblihtt, L. I., Carreras, M. C., & Blanco, G. A. C. (2016) · InTech eBooks · doi:10.5772/63306 · Cited by 4
VALORES NORMALES DE PESO AL NACER A 3 400 M DE ALTURA
Calanche, W. V., & Jerí-Palomino, M. (2015) · Revista Peruana de Ginecología y Obstetricia · doi:10.31403/rpgo.v57i177 · Cited by 4
Acute Inhibition of Selected Membrane-Proximal Mouse T Cell Receptor Signaling by Mitochondrial Antagonists
Kim, K., Wang, L., & Hwang, I. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007738 · Cited by 4
FACTORES DE LOS PADRES CONDICIONANTES DEL PESO AL NACER EN RECIÉN NACIDOS A TÉRMINO A 3 400 MSNM
Villamonte, W., Malaver, J., Salinas, R. A., Quispe, E., Laurent, A., Jerí-Palomino, M., Molina, G., & Núñez, V. (2015) · Revista Peruana de Ginecología y Obstetricia · doi:10.31403/rpgo.v57i179 · Cited by 4
Erythropoietin as Potential Neuroprotective and Antiepileptogenic Agent in Epilepsy and Refractory Epilepsy
Marelli, A., Czornyj, L. A., Rocha, L., & Lazarowski, A. (2016) · Methods in pharmacology and toxicology · doi:10.1007/978-1-4939-6355-3_8 · Cited by 4
Expression of miRNA-210 in human bone marrow-derived mesenchymal stromal cells under oxygen deprivation
Loncaric, D., Stanković, B., Ghousein, A., Vreća, M., Spasovski, V., Villacreces, A., Debeissat, C., Grosset, C. F., Ivanović, Z., & Pavlović, S. (2019) · Archives of Biological Sciences · doi:10.2298/abs181117001l · Cited by 4
Natural Products as Probes of Selected Targets in Tumor Cell Biology and Hypoxic Signaling
Nagle, D. G., & Zhou, Y. (2010) · Elsevier eBooks · doi:10.1016/b978-008045382-8.00054-x · Cited by 4
Flooding stress and O2 ‐shortage in plants
Iglesias‐Fernández, R., & Matilla, A. J. (2016) · doi:10.1002/9781119054450.ch41 · Cited by 4
Erratum To: Physiological Role of Aerobic Fermentation Constitutively Expressed in an Aluminum-Tolerant Cell Line of Tobacco (Nicotiana Tabacum)
Tsuchiya, Y., Nakamura, T., Izumi, Y., Okazaki, K., Shinano, T., Kubo, Y., Katsuhara, M., Sasaki, T., & Yamamoto, Y. (2021) · Plant and Cell Physiology · doi:10.1093/pcp/pcab131 · Cited by 4
NAD deficiency contributes to progressive kidney disease in HIV-nephropathy mice
Yoshida, T., Myakala, K., Jones, B. A., Wang, X. X., Shrivastav, S., Santo, B. A., Patel, T. R., Zhao, Y., Tutino, V. M., Sarder, P., et al. (2024) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00061.2024 · Cited by 3
Mitochondrial non-energetic function and embryonic cardiac development
Shi, J., Jin, Y., Lin, S., Li, X., Zhang, D., Wu, J., Qi, Y., & Li, Y. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1475603 · Cited by 4
Genotypic Influences on Actuators of Aerobic Performance in Tactical Athletes
Flück, M., Protte, C., Giraud, M., Gsponer, T., & Dössegger, A. (2024) · Genes · doi:10.3390/genes15121535 · Cited by 4
PDK1-mediated phosphorylation of USP5 modulates NF-κB signalling to enhance osteosarcoma growth
Yang, Z., Yu, Z., Teng, J., Yanzhang, R., Yin, Y., Zhang, H., Jin, G., & Wang, F. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.141378 · Cited by 3
Oxidative stress and inflammatory responses mediate the high mortality of Takifugu obscurus under combined hypoxia and Vibrio parahaemolyticus stress
Song, Y., Deng, N., Hou, J., Wu, Z., Lin, H., Li, S., & Lu, D. (2025) · Aquaculture Reports · doi:10.1016/j.aqrep.2025.103071 · Cited by 3
O2-Sensitive Probes Based on Phosphorescent Metalloporphyrins
Dmitriev, R. I., & Papkovsky, D. B. (2012) · SpringerBriefs in biochemistry and molecular biology · doi:10.1007/978-3-0348-0525-4_1 · Cited by 3
Studies of molecular pathways associated with blood neutrophil corticosteroid insensitivity in equine asthma
Dogaheh, S. P., Boivin, R., & Lavoie, J. (2021) · Veterinary Immunology and Immunopathology · doi:10.1016/j.vetimm.2021.110265 · Cited by 3
Distinct hypoxia-induced translational profiles of embryonic and adult-derived macrophages
Wilcox, N. S., Yarovinsky, T. O., Pandya, P., Ramgolam, V. S., Moro, A., Wu, Y., Nicoli, S., Hirschi, K. K., & Bender, J. R. (2023) · iScience · doi:10.1016/j.isci.2023.107985 · Cited by 4
The neurological symptoms clinical diagnostics role in patients with genetic diseases
Trishchynskaya, M. A., & Svystilnyk, V. A. (2019) · Modern medical technology · doi:10.34287/mmt.2(41).2019.42 · Cited by 3
The Role of Hypoxia in Adipocyte Function and Dysfunction
Trayhurn, P., de Heredia, F. P., Wang, B., & Wood, I. S. (2010) · Research and perspectives in endocrine interactions · doi:10.1007/978-3-642-13517-0_4 · Cited by 3
Hypoxia‐induced redox signalling in Müller cells
Griebsch, M., Klemm, M., Haueisen, J., & Hammer, M. (2016) · Acta Ophthalmologica · doi:10.1111/aos.13320 · Cited by 3
The Hypoxia-adenosinergic Immunosuppression and Redirection of Immune Response in Tumor Microenvironment
Ohta, A., & Sitkovsky, M. V. (2014) · Springer eBooks · doi:10.1007/978-1-4899-8056-4_14 · Cited by 3
Basic Experimental and Clinical Advances in the Mechanisms Underlying Abnormal Pregnancy Outcomes
Regnault, T. R. H., Nijland, M. J., Budge, H., & Morrison, J. L. (2013) · Journal of Pregnancy · doi:10.1155/2013/327638 · Cited by 3
Oxidative Phosphorylierung und Photophosphorylierung
Nelson, D. L., & Cox, M. M. (2008) · Springer-Lehrbuch · doi:10.1007/978-3-540-68638-5_19 · Cited by 3
Time-resolved monitoring of yeast responses to lipopolysaccharide exposure by cell-released volatile organic compounds
Liu, H., & Yao, M. (2025) · Applied and Environmental Microbiology · doi:10.1128/aem.00785-25 · Cited by 2
Metabolic Reprogramming of Macrophages Plays a Dual Role in Periodontitis: From Pathogenesis to Therapy
Chen, T., Ming, H., He, J., Zhou, F., Wang, D., Bai, F., Fang, T., Man, Y., & Wu, Y. (2026) · The FASEB Journal · doi:10.1096/fj.202600558rrr · Cited by 2
Hyperbaric oxygen exposure alleviate metabolic side-effects of olanzapine treatment and is associated with Langerhans islet proliferation in rats
Alqudah, M., Khalifeh, M., Al-Azaizeh, R., Masaadeh, A. H., Al-Rusan, O. M., & Haddad, H. K. (2022) · Pathology & Oncology Research · doi:10.3389/pore.2022.1610752 · Cited by 2
The Hypoxia Regulatory System in Hematopoietic Stem Cells
Takubo, K. (2012) · InTech eBooks · doi:10.5772/33124 · Cited by 2
Parallel synthesis enablement of 2-pyridyl-5-cyano-pyrimidine-6-ones—a novel class of HIF-hydroxylase inhibitors
Chang, S.-P., Hungerford, W. M., McDonald, W. S., Maguire, R. J., Malony, K. Q., & Subramanyam, C. (2009) · Tetrahedron Letters · doi:10.1016/j.tetlet.2009.12.040 · Cited by 2
Hibernating Myocardium: A Mitochondrial Adaptation that may be Destined to Heart Failure
Thomas, S., & McFalls, E. O. (2008) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-008-9069-2 · Cited by 2
Angiogenesis, Arteriogenesis, and Mitochondrial Dysfunction
McMurtry, M. S. (2013) · Springer eBooks · doi:10.1007/978-1-4614-5930-9_15 · Cited by 2
Comment le parasite Apicomplexe Theileria manipule-t-il l’identité cellulaire de son hôte bovin ?
Marsolier, J., & Weitzman, J. B. (2014) · Biologie Aujourd hui · doi:10.1051/jbio/2015004 · Cited by 2
Cardiovascular Physiology Applied to the Perioperative and Critical Care Settings
Cannesson, M. P., & Pearse, R. M. (2014) · Cambridge University Press eBooks · doi:10.1017/cbo9781107257115.006 · Cited by 2
Magnetic Resonance Spectroscopy in Investigating the Cancer Metabolome in Preclinical Model Systems
Penet, M., Bhujwalla, Z. M., & Glunde, K. (2013) · Cambridge University Press eBooks · doi:10.1017/cbo9780511996634.022 · Cited by 2
The question of the influence of the dosed tissue stretching on the concentration of the hypoxia-inducible factor (HIF-1α) in the stretched flap
Bagryantsev, M. V., Викторович, П. И., Shelchkova, N. A., Mironov, A. A., Ryabkov, M. G., & Beschastnov, V. V. (2017) · Journal of Experimental and Clinical Surgery · doi:10.18499/2070-478x-2017-10-4-283-287 · Cited by 2
mtDNA mutations in cancer
Girolimetti, G., Luise, M. D., Porcelli, A. M., Gasparre, G., & Kurelac, I. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819656-4.00017-6 · Cited by 2
Lung Adenocarcinoma Transcriptomic Analysis Predicts Adenylate Kinase Signatures Contributing to Tumor Progression and Negative Patient Prognosis
Chacon-Barahona, J. A., Salladay-Perez, I. A., & Lanning, N. J. (2021) · Metabolites · doi:10.3390/metabo11120859 · Cited by 2
Mitochondria as Targets for Cancer Therapy
Ralph, S. J., & Neužil, J. (2008) · Springer eBooks · doi:10.1007/978-0-387-84835-8_12 · Cited by 2
Angiogenesis, Computational Modeling Perspective
Qutub, A. A., & Popel, A. S. (2015) · Springer eBooks · doi:10.1007/978-3-540-70529-1_162 · Cited by 2
H,K-ATPase and carbonic anhydrase response to chronic systemic rat gastric hypoxia
Lutfiah, U., Jusman, S. W. A., & Sadikin, M. (2015) · Medical Journal of Indonesia · doi:10.13181/mji.v24i3.1066 · Cited by 1
Transcriptomic Analysis Reveals Mechanisms Underlying the Inhibitory Effects of (E)-2-Heptenal on Spore Germination of Aspergillus Flavus
Ren, J., Duan, W.-Y., Feng, Y.-W., Zhang, S., Lv, Y., Zhai, H.-C., Wei, S., Ma, P.-A., & Hu, Y. (2024) · Food Biophysics · doi:10.1007/s11483-024-09868-0 · Cited by 1
Identification of potential characteristic genes in chronic skin infections through RNA sequencing and immunohistochemical analysis
Cao, H., Xiong, W., Zeng, M., Li, H., Xu, Y., Wu, Z., & Hu, Y. (2024) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2024.12721 · Cited by 1
Pinewood Nematodes Manipulate Locomotion of the Vector Beetle Through ATP1‐Driven Energy Metabolism
Li, Y., Tang, X., Fan, Q., Sun, J., Ma, L., & Zhang, B. (2026) · Integrative Zoology · doi:10.1111/1749-4877.70060 · Cited by 1
Regulatory roles of gingival fibroblasts in periodontal homeostasis and inflammatory progression
Liu, S. L., Zhao, Z., Liu, N. N., & Liu, Q. (2026) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2026.106669 · Cited by 1
Gene Therapy Strategy for Tumour Hypoxia
Harada, H. (2011) · InTech eBooks · doi:10.5772/17645 · Cited by 1
Hypoxia in Pre-Eclampsia: Cause or Effect?
Karanam, V. L., Page, N., & Anim‐Nyame, N. (2010) · Current Women s Health Reviews · doi:10.2174/157340410793362131 · Cited by 1
[Fear of anemia or why don't we afraid of blood transfusion?].
Orlov, Y., Lukach, V., Govorova, N. V., & Baytugaeva, G. A. (2015) · Khirurgiia · doi:10.17116/hirurgia20151188-94 · Cited by 1
Posttranscriptional adaptations of the vascular endothelium to hypoxia
Ho, J. J. D., & Marsden, P. A. (2015) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000139 · Cited by 1
The Role of Succinate Dehydrogenase Enzyme in the Production of Reactive Oxygen Species: Review
Güleç, D. (2017) · Turkiye Klinikleri Journal of Internal Medicine · doi:10.5336/intermed.2017-54816 · Cited by 1
Short-term hypoxic vasodilationin vivois mediated by bioactive nitric oxide metabolites, rather than free nitric oxide derived from haemoglobin-mediated nitrite reduction
Umbrello, M., Dyson, A., Pinto, B. B., Fernandez, B. O., Simon, V., Feelisch, M., & Singer, M. (2014) · The Journal of Physiology · doi:10.1113/jphysiol.2014.255687 · Cited by 1
Effect of hypoxia and hyperglycemia on cell bioenergetics
Del Sole, M. <. (2012) · AMS Dottorato Institutional Doctoral Theses Repository (University of Bologna) · doi:10.6092/unibo/amsdottorato/4732 · Cited by 1
The Circadian–Hypoxia Link
Oyama, Y., Walker, L. A., & Eckle, T. D. L. G. (2024) · Royal Society of Chemistry eBooks · doi:10.1039/bk9781839167553-00136 · Cited by 1
The role of hypoxia-induced factor in the regulation of oxygen homeostasis during reparative regeneration in compromised microcirculation
Izmaylov, S. G., Beschastnov, V. V., Ryabkov, M. G., Leontev, A. E., Lukoyanychev, E. E., Bagryantsev, M. V., & Orlinskaya, N. Y. (2018) · Almanac of Clinical Medicine · doi:10.18786/2072-0505-2017-45-8-674-680 · Cited by 1
Oxygen Transfer Rate (OTR) Prediction Model for CHO Cell Culture in Shake Flasks
Ko, H., Yoo, H. W., & Baik, J. Y. (2022) · KSBB Journal · doi:10.7841/ksbbj.2022.37.1.32 · Cited by 1
The role of hypoxia-inducible factor-1 in hyperthermia-induced tumor reoxygenation and therapy resistance
Moon, E. J. (2010) · DukeSpace (Duke University) · Cited by 1
Human Cytomegalovirus Regulates Host Lipid Metabolism
Xi, Y. (2021) · UA Campus Repository (The University of Arizona) · Cited by 1
Correction: Adaptation and Mal-Adaptation to Ambient Hypoxia; Andean, Ethiopian and Himalayan Patterns
Xing, G., Qualls, C., Huicho, L., Rivera, M. C., Stobdan, T., Slessarev, M., Prisman, E., Ito, S., Wu, H., Norboo, A., et al. (2008) · PLoS ONE · doi:10.1371/annotation/500fe2d3-85ad-47e2-a1a2-356a3125df68 · Cited by 1
Reprogramming of energy metabolism by oncogenic Marek's disease virus (MDV) in chicken embryo fibroblasts (CEFs)
Siano, N. (2025) · Library, Museums and Press - UDSpace (University of Delaware) · doi:10.58088/8brr-wk43 · Cited by 1
Cellular Respiration and Tumor Suppressor Genes
Gonzalez‐Cuyar, L. F., Tavora, F. R. F., Caminha, I., Perry, G. L., Smith, M. A., & Castellani, R. J. (2008) · Humana Press eBooks · doi:10.1007/978-1-59745-435-3_10
Intricate Link between Hypoxia and Oxidative Stress in Chronic Kidney Disease
Tanaka, T. (2010) · Humana Press eBooks · doi:10.1007/978-1-60761-857-7_24
Quinones in aerobic and anaerobic mitochondria
van der Klei, S. A. (2009) · Utrecht University Repository (Utrecht University)
Regulation of Mitochondrial Function by Hypoxia and Inflammation in Sepsis: A Putative Role for Hypoxia Inducible Factor
Regueira, T., Jakob, S. M., & Djafarzadeh, S. (2008) · Yearbook of intensive care and emergency medicine · doi:10.1007/978-3-540-77290-3_36
Regulation of Mitochondrial Function by MicroRNA
Tomasetti, M., Dong, L., & Neužil, J. (2014) · Springer eBooks · doi:10.1007/978-94-017-8984-4_3
Consequences of dietarily- and genetically-induced iron deficiency on the neurodevelopment and experience-dependent plasticity of the hippocampus.
Carlson, E. S. (2008) · University of Minnesota Digital Conservancy (University of Minnesota)
Transcription Factors and Gene Expression
Dickenson, J. M., Freeman, F., Mills, C. L., Sivasubramaniam, S. D., & Thode, C. (2012) · Molecular Pharmacology · doi:10.1002/9781118451908.ch8
Biogenesis of respiratory chain: Rcf1 and Rcf2 as a novel assembly factors
Vukotic, M. (2012) · doi:10.53846/goediss-1447
Transcriptional Regulation Under Low Oxygen Stress in Plants
Giuntoli, B., & Pierdomenico Perata, A. (2013) · Plant cell monographs · doi:10.1007/978-3-7091-1254-0_5
Hypoxic Adaptation and Arsenic Trioxide Treatment in Small Cell Lung Carcinoma
Thorén, M. M. (2013) · Lund University Publications (Lund University)
Biometría fetal e Índice de líquido amniótico de 14 a 41 semanas a 3400 msnm y su comparación con tablas de otros niveles de altura fetal
Villamonte, W., Jerí-Palomino, M., & Dueñas, C. D. L. T. (2013) · Americanae (AECID Library)
Die Bedeutung des Hypoxie-induzierbaren Transkriptionsfaktors HIF-1 für die maligne Progression des humanen Magenkarzinoms
Rohwer, N. (2010) · Universitätsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver · doi:10.17169/refubium-16153
6-phosphofructo-2-kinase inhibition induces autophagy as a survival mechanism.
Klarer, A. C. (2013) · ThinkIR: The University of Louisville's Institutional Repository (University of Louisville) · doi:10.18297/etd/760
The effect of hypoxia on macrophage proteoglycans: potential role in atherosclerosis
Asplund, A. (2009) · Gothenburg University Publications Electronic Archive (Gothenburg University)
Effective use of small-interfering RNA to characterize residual B-cell non-Hodgkin lymphoma cells following chemotherapy
Shiramizu, B. T. (2012) · Journal of Hematological Malignancies · doi:10.5430/jhm.v2n1p5
The Leukemic Bone Marrow Microenvironment: Targeting Hypoxia with Hypoxia-Activated Prodrugs
Benito, J., Konopleva, M. Y., & Wilson, W. R. (2014) · Springer eBooks · doi:10.1007/978-1-4939-1393-0_35
Factores de riesgo maternos, fetales y ambientales asociados al bajo peso en recién nacidos/as de mujeres que han vivido los últimos 5 años en la localidad el Santuario Cantón Quero, Provincia de Tungurahua
Vaca, A., & Maricela, M. (2015) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
Hypoxic Preconditioning in the CNS
Gilchrist, R., & Gidday, J. M. (2012) · Springer eBooks · doi:10.1007/978-1-4419-9695-4_8

Authors: Semenza, G. L.
Affiliations: Johns Hopkins University (US)
Corresponding author: Semenza, Gregg L.
ORCID: Semenza, Gregg L.
Venue: Biochemical Journal
Publisher: Portland Press Ltd.
Published: 2007-06-13
Volume: 405
Issue: 1
Pages: 1-9
ISSN: 0264-6021 (ISSN-L)
1470-8728
DOI: 10.1042/bj20070389
OpenAlex: W1799768544
Cited by: 541
References: 113
Citations by year: 2026: 8 · 2025: 9 · 2024: 15 · 2023: 16 · 2022: 19 · 2021: 37 · 2020: 25 · 2019: 27 · 2018: 29 · 2017: 27 · 2016: 29 · 2015: 29 · 2014: 29 · 2013: 36 · 2012: 37
FWCI: 3.75
Type: journal article
Language: en
Open access: closed
Locations: Biochemical Journal (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (n01hv28180-13-0-0)
National Heart, Lung, and Blood Institute (N01 HV-28180, R01HL055338)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords: HIF-1, mitochondrial respiration, cytochrome c oxidase, PDK1, pyruvate dehydrogenase, LDHA, reactive oxygen species, electron transport chain, TCA cycle, Lon protease, oxygen homeostasis
MeSH terms: Pyruvate Dehydrogenase Acetyl-Transferring Kinase, Electron Transport Complex IV, Electron Transport, Gene Expression Regulation, Glucose, Glycolysis, Homeostasis, Mitochondria, Oxidative Phosphorylation, Oxygen, Protein Kinases, Protein Serine-Threonine Kinases, Cell Respiration, Hypoxia-Inducible Factor 1

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Oxygen-dependent regulation of mitochondrial respiration by hypoxia-inducible factor 1

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks