The DOI matches its Crossref record; 143 of the 143 references it cites were found in a registry or an index.
Connexin43 phosphorylation: structural changes and biological effects
Open accessAbstract
Vertebrate gap junctions, composed of proteins from the connexin gene family, play critical roles in embryonic development, co-ordinated contraction of excitable cells, tissue homoeostasis, normal cell growth and differentiation. Phosphorylation of connexin43, the most abundant and ubiquitously expressed connexin, has been implicated in the regulation of gap junctional communication at several stages of the connexin ‘life cycle’, including hemichannel oligomerization, export of the protein to the plasma membrane, hemichannel activity, gap junction assembly, gap junction channel gating and connexin degradation. Consistent with a short (1–5 h) protein half-life, connexin43 phosphorylation is dynamic and changes in response to activation of many different kinases. The present review assesses our current understanding of the effects of phosphorylation on connexin43 structure and function that in turn regulate gap junction biology, with an emphasis on events occurring in heart and skin.
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Cites
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Cited by
Kanady, J. D., Dellinger, M. T., Munger, S. J., Witte, M. H., & Simon, A. M. (2011) · Developmental Biology · doi:10.1016/j.ydbio.2011.04.004 · Cited by 184
Connexins: Key Mediators of Endocrine Function
Bosco, D., Haefliger, J.-A., & Meda, P. (2011) · Physiological Reviews · doi:10.1152/physrev.00027.2010 · Cited by 169
Glial Connexins and Pannexins in the Healthy and Diseased Brain
Giaume, C., Naus, C. C., Sáez, J. C., & Leybaert, L. (2021) · Physiological Reviews · doi:10.1152/physrev.00043.2018 · Cited by 154
Samarasinghe, R. A., Di Maio, R., Volonte, D., Galbiati, F., Lewis, M., Romero, G., & DeFranco, D. B. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1102821108 · Cited by 120
Protein–Protein Interactions with Connexin 43: Regulation and Function
Sorgen, P. L., Trease, A. J., Spagnol, G., Delmar, M., & Nielsen, M. S. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19051428 · Cited by 106
Metadata
- Authors
- Solan, J. L., & Lampe, P. D.
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 2009-03-27
- Volume
- 419
- Issue
- 2
- Pages
- 261-272
- ISSN
- 0264-6021 (ISSN-L)
- 1470-8728
- OpenAlex
- W2019015469
- Cited by
- 555
- References
- 143
- FWCI
- 19.92
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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