The DOI matches its Crossref record; 224 of the 224 references it cites were found in a registry or an index.
Endothelial dysfunction in vascular complications of diabetes: a comprehensive review of mechanisms and implications
Open accessAbstract
Diabetic vascular complications are prevalent and severe among diabetic patients, profoundly affecting both their quality of life and long-term prospects. These complications can be classified into macrovascular and microvascular complications. Under the impact of risk factors such as elevated blood glucose, blood pressure, and cholesterol lipids, the vascular endothelium undergoes endothelial dysfunction, characterized by increased inflammation and oxidative stress, decreased NO biosynthesis, endothelial-mesenchymal transition, senescence, and even cell death. These processes will ultimately lead to macrovascular and microvascular diseases, with macrovascular diseases mainly characterized by atherosclerosis (AS) and microvascular diseases mainly characterized by thickening of the basement membrane. It further indicates a primary contributor to the elevated morbidity and mortality observed in individuals with diabetes. In this review, we will delve into the intricate mechanisms that drive endothelial dysfunction during diabetes progression and its associated vascular complications. Furthermore, we will outline various pharmacotherapies targeting diabetic endothelial dysfunction in the hope of accelerating effective therapeutic drug discovery for early control of diabetes and its vascular complications.
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Cites
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Cited by
Endothelial Dysfunction as the Common Pathway Linking Obesity, Hypertension and Atherosclerosis
Młynarska, E., Bojdo, K., Frankenstein, H., Krawiranda, K., Kustosik, N., Lisińska, W., Rysz, J., & Franczyk, B. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262010096 · Cited by 87
Metadata
- Authors
- Yang, D.-R., Wang, M.-Y., Zhang, C.-L., & Wang, Y.
- Venue
- Frontiers in Endocrinology
- Publisher
- Frontiers Media SA
- Published
- 2024-04-05
- Volume
- 15
- Pages
- 1359255-1359255
- ISSN
- 1664-2392 (ISSN-L)
- OpenAlex
- W4393987103
- Cited by
- 280
- References
- 224
- FWCI
- 66.22
- Type
- journal article
- Language
- en
- Open access
- gold
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- Yang, D.-R., Wang, M.-Y., Zhang, C.-L., & Wang, Y. (2024). Endothelial dysfunction in vascular complications of diabetes: a comprehensive review of mechanisms and implications. Frontiers in Endocrinology. https://doi.org/10.3389/fendo.2024.1359255
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
