Distinctive binding of three antagonistic peptides to the ephrin-binding pocket of the EphA4 receptor

Eph-Ephrin Bidirectional Signaling in Physiology and Disease

Pasquale, E. B. (2008) · Cell · doi:10.1016/j.cell.2008.03.011 · Cited by 1,251 · see citing works

Eph receptors and ephrins in cancer: bidirectional signalling and beyond

Pasquale, E. B. (2010) · Nature reviews. Cancer · doi:10.1038/nrc2806 · Cited by 1,216 · see citing works

Eph receptor signalling casts a wide net on cell behaviour

Pasquale, E. B. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1662 · Cited by 1,013 · see citing works

Role of EphA4 and EphrinB3 in Local Neuronal Circuits That Control Walking

Kullander, K., Butt, S., Lebret, J. M., Lundfald, L., Restrepo, C. E., Rydström, A., Klein, R., & Kiehn, O. (2003) · Science · doi:10.1126/science.1079641 · Cited by 365 · see citing works

Crystal structure of an Eph receptor–ephrin complex

Himanen, J., Rajashankar, K. R., Lackmann, M., Cowan, C. A., Henkemeyer, M. J., & Nikolov, D. B. (2001) · Nature · doi:10.1038/414933a · Cited by 339 · see citing works

On the Convergent Evolution of Animal Toxins

Dauplais, M., Lecoq, A., Song, J., Cotton, J., Jamin, N., Gilquin, B., Roumestand, C., Vita, C., de Medeiros, C. L. C., Rowan, E. G., et al. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.7.4302 · Cited by 337 · see citing works

Axonal Regeneration and Lack of Astrocytic Gliosis in EphA4-Deficient Mice

Goldshmit, Y., Galea, M. P., Wise, G. E., Bartlett, P. F., & Turnley, A. M. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.2981-04.2004 · Cited by 318 · see citing works

Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism

Fu, W., Chen, Y., Şahin, M., Zhao, X.-S., Shi, L., Bikoff, J. B., Lai, K., Yung, W., Fu, A. K. Y., Greenberg, M. E., et al. (2006) · Nature Neuroscience · doi:10.1038/nn1811 · Cited by 311 · see citing works

Neuron-glia communication via EphA4/ephrin-A3 modulates LTP through glial glutamate transport

Filosa, A., Paixão, S., Honsek, S. D., Carmona, M. A., Becker, L., Feddersen, B., Gaitanos, L., Rudhard, Y., Schoepfer, R., Klopstock, T., et al. (2009) · Nature Neuroscience · doi:10.1038/nn.2394 · Cited by 283 · see citing works

Architecture of Eph receptor clusters

Himanen, J. P., Yermekbayeva, L., Janes, P. W., Walker, J. R., Xu, K. Y., Atapattu, L., Rajashankar, K. R., Mensinga, A., Lackmann, M., Nikolov, D. B., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1004148107 · Cited by 259 · see citing works

Kinase-Dependent and Kinase-Independent Functions of EphA4 Receptors in Major Axon Tract Formation In Vivo

Kullander, K., Mather, N. K., Diella, F., Dottori, M., Boyd, A., & Klein, R. (2001) · Neuron · doi:10.1016/s0896-6273(01)00181-7 · Cited by 258 · see citing works

Hippocampal plasticity requires postsynaptic ephrinBs

Kadow, I. C. G., Körte, M., Adelmann, G., Plück, A., Kullander, K., Adams, R. H., Frotscher, M., Bonhoeffer, T., & Klein, R. (2003) · Nature Neuroscience · doi:10.1038/nn1164 · Cited by 252 · see citing works

Molecular Features of the Transition from Prostatic Intraepithelial Neoplasia (PIN) to Prostate Cancer

Ashida, S., Nakagawa, H., Katagiri, T., Furihata, M., Iiizumi, M., Anazawa, Y., Tsunoda, T., Takata, R., Kasahara, K., Miki, T., et al. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-0020 · Cited by 239 · see citing works

An extracellular steric seeding mechanism for Eph-ephrin signaling platform assembly

Seiradake, E., Harlos, K., Sutton, G. C., Aricescu, A. R., & Jones, E. Y. (2010) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1782 · Cited by 222 · see citing works

An Ephrin Mimetic Peptide That Selectively Targets the EphA2 Receptor

Koolpe, M., Dail, M., & Pasquale, E. B. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m208495200 · Cited by 211 · see citing works

Glial ephrin-A3 regulates hippocampal dendritic spine morphology and glutamate transport

Carmona, M. A., Murai, K. K., Wang, L., Roberts, A. J., & Pasquale, E. B. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903328106 · Cited by 208 · see citing works

Magnetic Nanoparticle−Peptide Conjugates for in Vitro and in Vivo Targeting and Extraction of Cancer Cells

Scarberry, K. E., Dickerson, E. B., McDonald, J. F., & Zhang, Z. J. (2008) · Journal of the American Chemical Society · doi:10.1021/ja801969b · Cited by 201 · see citing works

Cooperation between GDNF/Ret and ephrinA/EphA4 Signals for Motor-Axon Pathway Selection in the Limb

Kramer, E. R., Knott, L., Su, F., Dessaud, É., Krull, C. E., Helmbacher, F., & Klein, R. (2006) · Neuron · doi:10.1016/j.neuron.2006.02.020 · Cited by 195 · see citing works

Eph–ephrin promiscuity is now crystal clear

Pasquale, E. B. (2004) · Nature Neuroscience · doi:10.1038/nn0504-417 · Cited by 167 · see citing works

Aberrant Expression of the Tyrosine Kinase Receptor EphA4 and the Transcription Factor Twist in Sezary Syndrome Identified by Gene Expression Analysis

van Doorn, R., Dijkman, R., Vermeer, M. H., Out‐Luiting, J. J., van der Raaij-Helmer, E. M. H., Willemze, R., & Tensen, C. P. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1253 · Cited by 163 · see citing works

Expression and Tyrosine Phosphorylation of Eph Receptors Suggest Multiple Mechanisms in Patterning of the Visual System

Connor, R., Menzel, P., & Pasquale, E. B. (1998) · Developmental Biology · doi:10.1006/dbio.1997.8786 · Cited by 151 · see citing works

The EphA4 receptor regulates dendritic spine remodeling by affecting β1-integrin signaling pathways

Bourgin, C., Murai, K. K., Richter, M., & Pasquale, E. B. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200610139 · Cited by 147 · see citing works

EphA4 promotes cell proliferation and migration through a novel EphA4-FGFR1 signaling pathway in the human glioma U251 cell line

Fukai, J., Yokote, H., Yamanaka, R., Arao, T., Nishio, K., & Itakura, T. (2008) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-07-2263 · Cited by 147 · see citing works

EphB Receptor-binding Peptides Identified by Phage Display Enable Design of an Antagonist with Ephrin-like Affinity

Koolpe, M., Burgess, R., Dail, M., & Pasquale, E. B. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m500363200 · Cited by 143 · see citing works

Small Molecules Can Selectively Inhibit Ephrin Binding to the EphA4 and EphA2 Receptors

Noberini, R., Koolpe, M., Peddibhotla, S., Dahl, R. S., Su, Y., Cosford, N. D. P., Roth, G. P., & Pasquale, E. B. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m804103200 · Cited by 135 · see citing works

Eph/Ephrin Profiling in Human Breast Cancer Reveals Significant Associations between Expression Level and Clinical Outcome

Brantley‐Sieders, D. M., Jiang, A., Sarma, K., Badu-Nkansah, A., Walter, D. L., Shyr, Y., & Chen, J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024426 · Cited by 134 · see citing works

Regeneration‐enhancing effects of EphA4 blocking peptide following corticospinal tract injury in adult rat spinal cord

Fabes, J., Anderson, P. N., Brennan, C. H., & Bolsover, S. R. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05859.x · Cited by 116 · see citing works

Alkaline phosphatase fusions of ligands or receptors as in situ probes for staining of cells, tissues, and embryos

Flanagan, J. G., Cheng, H.-J., Feldheim, D. A., Hattori, M., Lü, Q., & Vanderhaeghen, P. (2000) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(00)27264-9 · Cited by 113 · see citing works

Targeting the EphA4 receptor in the nervous system with biologically active peptides

Murai, K. K., Nguyen, L. N., Koolpe, M., McLennan, R., Krull, C. E., & Pasquale, E. B. (2003) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2003.08.006 · Cited by 106 · see citing works

Targeting Eph receptors with peptides and small molecules: Progress and challenges

Noberini, R., Lamberto, I., & Pasquale, E. B. (2011) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2011.10.023 · Cited by 103 · see citing works

Structural Characterization of the EphA4-Ephrin-B2 Complex Reveals New Features Enabling Eph-Ephrin Binding Promiscuity

Qin, H., Noberini, R., Huan, X., Shi, J., Pasquale, E. B., & Song, J. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.064824 · Cited by 101 · see citing works

RNAi screen for rapid therapeutic target identification in leukemia patients

Tyner, J. W., Deininger, M. W., Loriaux, M., Chang, B. H., Gotlib, J. R., Willis, S. G., Erickson, H. S., Kovacsovics, T. J., O’Hare, T., Heinrich, M. C., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903233106 · Cited by 99 · see citing works

Structural and Biophysical Characterization of the EphB4·EphrinB2 Protein-Protein Interaction and Receptor Specificity

Chrencik, J., Brooun, A., Kraus, M. L., Recht, M. I., Kolatkar, A. R., Han, G. W., Seifert, J. M., Widmer, H., Auer, M., & Kühn, P. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m605766200 · Cited by 97 · see citing works

Structural Plasticity of Eph Receptor A4 Facilitates Cross-Class Ephrin Signaling

Bowden, T. A., Aricescu, A. R., Nettleship, J. E., Siebold, C., Rahman-Huq, N., Owens, R. J., Stuart, D. I., & Jones, E. Y. (2009) · Structure · doi:10.1016/j.str.2009.07.018 · Cited by 95 · see citing works

Lithocholic Acid Is an Eph-ephrin Ligand Interfering with Eph-kinase Activation

Giorgio, C., Mohamed, I. H., Flammini, L., Barocelli, E., Incerti, M., Lodola, A., & Tognolini, M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018128 · Cited by 84 · see citing works

Accumulation of the inhibitory receptor EphA4 may prevent regeneration of corticospinal tract axons following lesion

Fabes, J., Anderson, P. N., Yáñez‐Muñoz, R. J., Thrasher, A. J., Brennan, C. H., & Bolsover, S. R. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04704.x · Cited by 83 · see citing works

Crystal Structure and NMR Binding Reveal That Two Small Molecule Antagonists Target the High Affinity Ephrin-binding Channel of the EphA4 Receptor

Qin, H., Shi, J., Noberini, R., Pasquale, E. B., & Song, J. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m804114200 · Cited by 80 · see citing works

Peptide-conjugated polymeric micellar nanoparticles for Dual SPECT and optical imaging of EphB4 receptors in prostate cancer xenografts

Zhang, R., Xiong, C., Huang, M. L., Zhou, M., Huang, Q., Wen, X., Liang, D., & Li, C. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.04.070 · Cited by 78 · see citing works

EphA and ephrin-A proteins regulate integrin-mediated T lymphocyte interactions

Sharfe, N., Nikolic, M., Cimpeon, L., Kratts, A. V. D., Freywald, A., & Roifman, C. M. (2007) · Molecular Immunology · doi:10.1016/j.molimm.2007.09.019 · Cited by 74 · see citing works

Overexpression of the receptor tyrosine kinase EphA4 in human gastric cancers

Oki, M., Yamamoto, H., Taniguchi, H., Adachi, Y., Imai, K., & Shinomura, Y. (2008) · World Journal of Gastroenterology · doi:10.3748/wjg.14.5650 · Cited by 72 · see citing works

EphA4 receptor, overexpressed in pancreatic ductal adenocarcinoma, promotes cancer cell growth

Iiizumi, M., Hosokawa, M., Takehara, A., Chung, S., Nakamura, T., Katagiri, T., Eguchi, H., Ohigashi, H., Ishikawa, O., Nakamura, Y., et al. (2006) · Cancer Science · doi:10.1111/j.1349-7006.2006.00313.x · Cited by 71 · see citing works

Protein dynamics and conformational selection in bidirectional signal transduction

Nussinov, R., & Ma, B. (2012) · BMC Biology · doi:10.1186/1741-7007-10-2 · Cited by 65 · see citing works

EphA4 preserves postnatal and adult neural stem cells in an undifferentiated state in vivo

Khodosevich, K. V., Watanabe, Y., & Monyer, H. (2011) · Journal of Cell Science · doi:10.1242/jcs.076059 · Cited by 63 · see citing works

Three-dimensional Structure of the EphB2 Receptor in Complex with an Antagonistic Peptide Reveals a Novel Mode of Inhibition

Chrencik, J., Brooun, A., Recht, M. I., Nicola, G., Davis, L. K., Abagyan, R. A., Widmer, H., Pasquale, E. B., & Kühn, P. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m706340200 · Cited by 62 · see citing works

EphA4 Signaling in Juveniles Establishes Topographic Specificity of Structural Plasticity in the Hippocampus

Galimberti, I., Bednarek, E., Donato, F., & Caroni, P. (2010) · Neuron · doi:10.1016/j.neuron.2010.02.016 · Cited by 60 · see citing works

Ephrin-A6, a New Ligand for EphA Receptors in the Developing Visual System

Menzel, P., Valencia, F., Godement, P., Dodelet, V. C., & Pasquale, E. B. (2001) · Developmental Biology · doi:10.1006/dbio.2000.0109 · Cited by 59 · see citing works

Selective removal of ovarian cancer cells from human ascites fluid using magnetic nanoparticles

Scarberry, K. E., Dickerson, E. B., Zhang, Z. J., Benigno, B. B., & McDonald, J. F. (2009) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2009.11.003 · Cited by 58 · see citing works

Upregulation of EphA4 on Astrocytes Potentially Mediates Astrocytic Gliosis after Cortical Lesion in the Marmoset Monkey

Goldshmit, Y., & Bourne, J. A. (2010) · Journal of Neurotrauma · doi:10.1089/neu.2010.1294 · Cited by 49 · see citing works

In Vivo Small-Animal PET/CT of EphB4 Receptors Using 64Cu-Labeled Peptide

Xiong, C., Huang, M. L., Zhang, R., Song, S., Lü, W., Flores, L. G., Gelovani, J. G., & Li, C. (2011) · Journal of Nuclear Medicine · doi:10.2967/jnumed.110.081943 · Cited by 45 · see citing works

EphrinA/EphA signal facilitates insulin-like growth factor-I–induced myogenic differentiation through suppression of the Ras/extracellular signal–regulated kinase 1/2 cascade in myoblast cell lines

MINAMI, M., Koyama, T., Wakayama, Y., Fukuhara, S., & Mochizuki, N. (2011) · Molecular Biology of the Cell · doi:10.1091/mbc.e11-03-0183 · Cited by 42 · see citing works

A Disalicylic Acid‐Furanyl Derivative Inhibits Ephrin Binding to a Subset of Eph Receptors

Noberini, R., De, S. K., Zhang, Z., Wu, B., Dhanya, R.-P., Chen, V., Vázquez, J., Qin, H., Song, J., Cosford, N. D. P., et al. (2011) · Chemical Biology & Drug Design · doi:10.1111/j.1747-0285.2011.01199.x · Cited by 41 · see citing works

PEGylation Potentiates the Effectiveness of an Antagonistic Peptide That Targets the EphB4 Receptor with Nanomolar Affinity

Noberini, R., Mitra, S., Salvucci, O., Valencia, F., Duggineni, S., Prigozhina, N. L., Wei, K., Tosato, G., Huang, Z., & Pasquale, E. B. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028611 · Cited by 40 · see citing works

Crystal structure of the ligand-binding domain of the promiscuous EphA4 receptor reveals two distinct conformations

Singla, N., Goldgur, Y., Xu, K. Y., Paavilainen, S., Nikolov, D. B., & Himanen, J. P. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.07.109 · Cited by 30 · see citing works

Targeted Removal of Migratory Tumor Cells by Functionalized Magnetic Nanoparticles Impedes Metastasis and Tumor Progression

Scarberry, K. E., Mezencev, R., & McDonald, J. F. (2010) · Nanomedicine · doi:10.2217/nnm.10.103 · Cited by 30 · see citing works

Protein dynamics at Eph receptor-ligand interfaces as revealed by crystallography, NMR and MD simulations

Qin, H., Lim, L., & Song, J. (2012) · BMC Biophysics · doi:10.1186/2046-1682-5-2 · Cited by 23 · see citing works

Use of protein array to investigate receptor tyrosine kinases activated in gastric cancer

Masaki, M. (2009) · International Journal of Oncology · doi:10.3892/ijo_00000480 · Cited by 20 · see citing works

[11] Utility of the secreted placental alkaline phosphatase reporter enzyme

Cullen, B. R. (2000) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(00)26053-9 · Cited by 15 · see citing works

Pathway-specific engagement of ephrinA5-EphA4/EphA5 system of the substantia nigra pars reticulata in cocaine-induced responses

Kimura, K., Hikida, T., Yawata, S., Yamaguchi, T., & Nakanishi, S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1107592108 · Cited by 12 · see citing works

Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease

Guo, T., Zhang, D., Zeng, Y., Huang, T. Y., Xu, H., & Zhao, Y. (2020) · Molecular Neurodegeneration · doi:10.1186/s13024-020-00391-7 · Cited by 994 · see citing works

A breast cancer stem cell niche supported by juxtacrine signalling from monocytes and macrophages

Lu, H., Clauser, K. R., Tam, W. L., Fröse, J., Ye, X., Eaton, E. N., Reinhardt, F., Donnenberg, V. S., Bhargava, R., Carr, S. A., et al. (2014) · Nature Cell Biology · doi:10.1038/ncb3041 · Cited by 457 · see citing works

Eph Receptors and Ephrins: Therapeutic Opportunities

Barquilla, A., & Pasquale, E. B. (2014) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-011112-140226 · Cited by 294 · see citing works

Blockade of EphA4 signaling ameliorates hippocampal synaptic dysfunctions in mouse models of Alzheimer’s disease

Fu, A. K. Y., Hung, K.-W., Huang, H., Gu, S., Shen, Y., Cheng, E. Y. L., Ip, F. C. F., Huang, X., Fu, W.-Y., & Ip, N. Y. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1405803111 · Cited by 201 · see citing works

Eph receptors and ephrins as targets for cancer therapy

Xi, H., Wu, X., Wei, B., & Chen, L. (2012) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2012.01612.x · Cited by 131 · see citing works

EphA4 Activation of c-Abl Mediates Synaptic Loss and LTP Blockade Caused by Amyloid-β Oligomers

Vargas, L. M., Leal, N. R., Estrada, L. D., González, A., Serrano, F. G., Araya, K. A., Gysling, K., Inestrosa, N. C., Pasquale, E. B., & Alvarez, A. R. (2014) · PLoS ONE · doi:10.1371/journal.pone.0092309 · Cited by 85 · see citing works

An Insight into Cellular and Molecular Mechanisms Underlying the Pathogenesis of Neurodegeneration in Alzheimer’s Disease

Ratan, Y., Rajput, A., Maleysm, S., Pareek, A., Jain, V. K., Pareek, A., Kaur, R., & Singh, G. (2023) · Biomedicines · doi:10.3390/biomedicines11051398 · Cited by 87 · see citing works

HTS by NMR of Combinatorial Libraries: A Fragment-Based Approach to Ligand Discovery

Wu, B., Zhang, Z., Noberini, R., Barile, E., Giulianotti, M. A., Pinilla, C., Houghten, R. A., Pasquale, E. B., & Pellecchia, M. (2013) · Chemistry & Biology · doi:10.1016/j.chembiol.2012.10.015 · Cited by 80 · see citing works

Therapeutic Development in Amyotrophic Lateral Sclerosis

Bucchia, M., Ramirez, A., Parente, V., Simone, C., Nizzardo, M., Magri, F., Dametti, S., & Corti, S. P. (2015) · Clinical Therapeutics · doi:10.1016/j.clinthera.2014.12.020 · Cited by 77 · see citing works

Amyloid-β oligomers synaptotoxicity: The emerging role of EphA4/c-Abl signaling in Alzheimer's disease

Vargas, L. M., Cerpa, W. F., Muñoz, F. J., Zanlungo, S., & Alvarez, A. R. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.01.023 · Cited by 69 · see citing works

High-Throughput Screening by Nuclear Magnetic Resonance (HTS by NMR) for the Identification of PPIs Antagonists

Wu, B., Barile, E., De, S. K., Wei, J., Purves, A., & Pellecchia, M. (2015) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026615666150519102459 · Cited by 61 · see citing works

Targeting the Eph System with Peptides and Peptide Conjugates

Riedl, S. J., & Pasquale, E. B. (2015) · Current Drug Targets · doi:10.2174/1389450116666150727115934 · Cited by 54 · see citing works

Potent and Selective EphA4 Agonists for the Treatment of ALS

Wu, B., De, S. K., Kulinich, A. O., Salem, A. F., Koeppen, J., Wang, R., Barile, E., Wang, S., Zhang, D., Ethell, I. M., et al. (2017) · Cell chemical biology · doi:10.1016/j.chembiol.2017.01.006 · Cited by 52 · see citing works

EphA4/Tie2 crosstalk regulates leptomeningeal collateral remodeling following ischemic stroke

Okyere, B., Mills, W. A., Wang, X., Chen, M., Jiang, C., Hazy, A., Qian, Y., Matson, J. B., & Theus, M. H. (2019) · Journal of Clinical Investigation · doi:10.1172/jci131493 · Cited by 48 · see citing works

Dynamic Principle for Designing Antagonistic/Agonistic Molecules for EphA4 Receptor, the Only Known ALS Modifier

Qin, H., Lim, L., & Song, J. (2014) · ACS Chemical Biology · doi:10.1021/cb500413n · Cited by 48 · see citing works

The Role of Ephs and Ephrins in Memory Formation

Dines, M., & Lamprecht, R. (2016) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyv106 · Cited by 47 · see citing works

Druggable Orthosteric and Allosteric Hot Spots to Target Protein-protein Interactions

Ma, B., & Nussinov, R. (2014) · Current Pharmaceutical Design · doi:10.2174/13816128113199990073 · Cited by 45 · see citing works

Development and Structural Analysis of a Nanomolar Cyclic Peptide Antagonist for the EphA4 Receptor

Lamberto, I., Lechtenberg, B. C., Olson, E. J., Mace, P. D., Dawson, P. E., Riedl, S. J., & Pasquale, E. B. (2014) · ACS Chemical Biology · doi:10.1021/cb500677x · Cited by 40 · see citing works

Identification and characterization of Nanobodies targeting the EphA4 receptor

Schoonaert, L., Rué, L., Roucourt, B., Timmers, M., Little, S., Chávez‐Gutiérrez, L., Dewilde, M., Joyce, P. I., Curnock, A. P., Weber, P., et al. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.774141 · Cited by 39 · see citing works

Tie2 and Eph Receptor Tyrosine Kinase Activation and SignalingPreprint

Barton, W. A., Dalton, A. C., Seegar, T. C. M., Himanen, J. P., & Nikolov, D. B. (2014) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a009142 · Cited by 35 · see citing works

Human ribonuclease 1 serves as a secretory ligand of ephrin A4 receptor and induces breast tumor initiation

Lee, H.-H., Wang, Y.-N., Yang, W.-H., Xia, W., Wei, Y.-K., Chan, L.-C., Wang, Y.-H., Jiang, Z., Xu, S., Yao, J., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-23075-2 · Cited by 24 · see citing works

Overexpressed gene signature of EPH receptor A/B family in cancer patients-comprehensive analyses from the public high-throughput database.

Phan, N. N., Liu, S., Wang, C., Hsu, H., Lai, M., Li, C.-Y., Chen, C., Chiao, C.-C., Yen, M., Sun, Z., et al. (2020) · PubMed Central · Cited by 28 · see citing works

Inhibition of Eph receptor A4 by 2,5-dimethylpyrrolyl benzoic acid suppresses human pancreatic cancer growing orthotopically in nude mice

Takano, H., Nakamura, T., Tsuchikawa, T., Kushibiki, T., Hontani, K., Inoko, K., Takahashi, M., Sato, S., Abe, H., Takeuchi, S., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.5729 · Cited by 24 · see citing works

Targeting kinase signaling pathways with constrained peptide scaffolds

Hanold, L. E., Fulton, M. D., & Kennedy, E. J. (2017) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.02.014 · Cited by 23 · see citing works

Inhibition of Eph receptor–ephrin ligand interaction by tea polyphenols

Noberini, R., Koolpe, M., Lamberto, I., & Pasquale, E. B. (2012) · Pharmacological Research · doi:10.1016/j.phrs.2012.05.010 · Cited by 20 · see citing works

Thermodynamics parameters for binding of halogenated benzotriazole inhibitors of human protein kinase CK2α

Winiewska‐Szajewska, M., Kucińska, K., Makowska, M., Poznański, J. T., & Shugar, D. (2015) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2015.04.004 · Cited by 19 · see citing works

EphA4-ADAM10 Interplay Patterns the Cochlear Sensory Epithelium through Local Disruption of Adherens Junctions

Defourny, J., Peuckert, C., Kullander, K., & Malgrange, B. (2018) · iScience · doi:10.1016/j.isci.2018.12.017 · Cited by 18 · see citing works

Unique Structure and Dynamics of the EphA5 Ligand Binding Domain Mediate Its Binding Specificity as Revealed by X-ray Crystallography, NMR and MD Simulations

Huan, X., Shi, J., Lim, L., Mitra, S., Zhu, W., Qin, H., Pasquale, E. B., & Song, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0074040 · Cited by 16 · see citing works

The roles and therapeutic potentials of Ephs and ephrins in lung cancer

Li, J., & Xie, D. (2012) · Experimental Cell Research · doi:10.1016/j.yexcr.2012.08.005 · Cited by 14 · see citing works

Targeting the brain lesions using peptides: A review focused on the possibility of targeted drug delivery to multiple sclerosis lesions

Rayatpour, A., & Javan, M. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105441 · Cited by 14 · see citing works

Potential entry receptors for human γ-herpesvirus into epithelial cells: A plausible therapeutic target for viral infections

Rani, A., Jakhmola, S., Karnati, S., Parmar, H. S., & Jha, H. C. (2021) · Tumour Virus Research · doi:10.1016/j.tvr.2021.200227 · Cited by 14 · see citing works

EphrinA4 mimetic peptide targeted to EphA binding site impairs the formation of long-term fear memory in lateral amygdala

Dines, M., & Lamprecht, R. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.76 · Cited by 14 · see citing works

Regulation of axonal EphA4 forward signaling is involved in the effect of EphA3 on chicken retinal ganglion cell axon growth during retinotectal mapping

Fiore, L., Medori, M., Spelzini, G., Olmos-Carreño, C. L., Carri, N. G., Sánchez, V., & Scicolone, G. E. (2018) · Experimental Eye Research · doi:10.1016/j.exer.2018.09.007 · Cited by 13 · see citing works

Mechanistic and therapeutic implications of EphA‐4 receptor tyrosine kinase in the pathogenesis of Alzheimer's disease

Ganguly, D., Thomas, J. A., Ali, A., & Kumar, R. K. (2022) · European Journal of Neuroscience · doi:10.1111/ejn.15591 · Cited by 12 · see citing works

Distinctive Structure of the EphA3/Ephrin-A5 Complex Reveals a Dual Mode of Eph Receptor Interaction for Ephrin-A5

Forse, G. J., Uson, M. L., Nasertorabi, F., Kolatkar, A. R., Lamberto, I., Pasquale, E. B., & Kühn, P. (2015) · PLoS ONE · doi:10.1371/journal.pone.0127081 · Cited by 12 · see citing works

Investigation of the interactions between the EphB2 receptor and SNEW peptide variants

Ma, B., Kolb, S., Diprima, M., Karna, M., Tosato, G., Yang, Q., Huang, Q., & Nussinov, R. (2014) · Growth Factors · doi:10.3109/08977194.2014.985786 · Cited by 10 · see citing works

NMR-Guided Design of Potent and Selective EphA4 Agonistic Ligands

Baggio, C., Kulinich, A. O., Dennys, C. N., Rodrigo, R., Meyer, K., Ethell, I. M., & Pellecchia, M. (2021) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.1c00608 · Cited by 10 · see citing works

Increased Expression of Ephrins on Immune Cells of Patients with Relapsing Remitting Multiple Sclerosis Affects Oligodendrocyte Differentiation

Golan, M., Krivitsky, A., Mausner-Fainberg, K., Benhamou, M., Vigiser, I., Regev, K., Kolb, H., & Karni, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22042182 · Cited by 8 · see citing works

Evaluation of a novel EphA2 targeting peptide for triple negative breast cancer based on radionuclide molecular imaging

Qu, B., Han, Y., Liang, T. B., Zhang, C., Hou, G., & Gao, F. (2022) · Arabian Journal of Chemistry · doi:10.1016/j.arabjc.2022.104211 · Cited by 5 · see citing works

Lipidation and PEGylation strategies to prolong the in vivo half-life of a nanomolar EphA4 receptor antagonist

Gómez‐Soler, M., Olson, E. J., de la Torre, E. R., Zhao, C., Lamberto, I., Flood, D. T., Danho, W., Lechtenberg, B. C., Riedl, S. J., Dawson, P. E., et al. (2023) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2023.115876 · Cited by 5 · see citing works

Neurodegeneration-associated protein VAPB regulates proliferation in medulloblastoma

Assoni, A. F., Mitsugi, T., Wardenaar, R., Ferreira, R. O., Jandrey, E. H. F., Novaes, G. M., Granha, I. F. D. O., Bakker, P. L., Kaid, C., Zatz, M., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-45319-5 · Cited by 4 · see citing works

Structural insights into EphA4 unconventional activation from prediction of the EphA4 and its complex with ribonuclease 1.

Li, Y., Yamaguchi, H., Liu, Y., Hsu, K.-C., Sun, T.-H., Sun, P.-C., & Hung, M. (2022) · PubMed Central · Cited by 4 · see citing works

Mechanisms of self-assembly and fibrillization of the prion-like domainsPreprint

Lu, Y., Lim, L., Tan, Y., Wang, L., & Song, J. (2016) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/065631 · Cited by 3 · see citing works

After Traumatic Brain Injury, EPHA4 Enhances Endoplasmic Reticulum Stress to Promote M1 Microglial Polarization Through the MAPK Signaling Pathway

Tan, Y., Xia, J., Liu, M., Deng, S., Wu, H., & Qian, C. (2026) · Mediators of Inflammation · doi:10.1155/mi/5595023 · Cited by 2 · see citing works

Eph-mediated restriction of cerebrovascular arteriogenesis

Okyere, B. (2019) · VTechWorks (Virginia Tech) · Cited by 1 · see citing works

Faculty Opinions recommendation of Human ribonuclease 1 serves as a secretory ligand of ephrin A4 receptor and induces breast tumor initiation.

Davy, A. (2021) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.740114516.793585641

A função de proteínas associadas à Esclerose Lateral Amiotrófica em diferentes contextos celulares

Assoni, A. F. (2022) · doi:10.11606/t.41.2022.tde-02082022-190632

Selective modulation of the Protein Kinase CK2 : discovery, syntheses and characterization of non-ATP site inhibitors of CK2

Bestgen, B. (2015) · doi:10.70675/af61ef7cz4fe8z4ac9z8eb7z75b5509c33dc

BindingDB Entry 50014039: NMR-Guided Design of Potent and Selective EphA4 Agonistic Ligands.

BindingDB (2022) · UC San Diego · doi:10.7270/q2pk0kxt

BindingDB Entry 7902: Potent and Selective EphA4 Agonists for the Treatment of ALS.

BindingDB (2017) · UC San Diego · doi:10.7270/q2gx49fb

Structural and Binding Study on the Interaction of Small Molecule Antagonists with the EphA4 Receptor

Qin, H., Shi, J., Noberini, R., Pasquale, E. B., & Song, J. (2009) · The FASEB Journal · doi:10.1096/fasebj.23.1_supplement.lb297

Structure and Thermodynamic Characterization of the EphB4/Ephrin-B2 Antagonist Peptide Complex Reveals the Determinants for Receptor Specificity

Chrencik, J., Brooun, A., Recht, M. I., Kraus, M. L., Koolpe, M., Kolatkar, A. R., Bruce, R. H., Martiny‐Baron, G., Widmer, H., Pasquale, E. B., et al. (2006) · Structure · doi:10.1016/j.str.2005.11.011 · Cited by 87 · see citing works

Crystal Structure and NMR Binding Reveal That Two Small Molecule Antagonists Target the High Affinity Ephrin-binding Channel of the EphA4 Receptor

Qin, H., Shi, J., Noberini, R., Pasquale, E. B., & Song, J. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m804114200 · Cited by 80 · see citing works

Development and Structural Analysis of a Nanomolar Cyclic Peptide Antagonist for the EphA4 Receptor

Riedl, S. J., & Pasquale, E. B. (2016)

Discovery and Characterization of a Novel Cyclic Peptide That Effectively Inhibits Ephrin Binding to the EphA4 Receptor and Displays Anti-Angiogenesis Activity

Han, X., Xu, Y., Yang, Y., Xi, J., Wang, T., Duggineni, S., Huang, Z., & An, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0080183 · Cited by 16 · see citing works