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Cited by 47Memory and Neural MechanismsNeuroscience and Neuropharmacology ResearchAxon Guidance and Neuronal Signaling

The Role of Ephs and Ephrins in Memory Formation

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Dines, Monica, Lamprecht, Raphael·2016·International Journal of Neuropsychopharmacology
DOI 10.1093/ijnp/pyv106PMC PMC4851260
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Abstract

The ability to efficiently store memories in the brain is a fundamental process and its impairment is associated with multiple human mental disorders. Evidence indicates that long-term memory formation involves alterations of synaptic efficacy produced by modifications in neural transmission and morphology. The Eph receptors and their cognate ephrin ligands have been shown to be involved in these key neuronal processes by regulating events such as presynaptic transmitter release, postsynaptic glutamate receptor conductance and trafficking, synaptic glutamate reuptake, and dendritic spine morphogenesis. Recent findings show that Ephs and ephrins are needed for memory formation in different organisms. These proteins participate in the formation of various types of memories that are subserved by different neurons and brain regions. Ephs and ephrins are involved in brain disorders and diseases with memory impairment symptoms, including Alzheimer's disease and anxiety. Drugs that agonize or antagonize Ephs/ephrins signaling have been developed and could serve as therapeutic agents to treat such diseases. Ephs and ephrins may therefore induce cellular alterations mandatory for memory formation and serve as a target for pharmacological intervention for treatment of memory-related brain diseases.

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Cited by

Sorted by citations

Authors
Dines, M., & Lamprecht, R.
Affiliations
University of Haifa (IL)
Corresponding author
Lamprecht, Raphael
ORCID
Lamprecht, Raphael
Venue
International Journal of Neuropsychopharmacology
Publisher
Oxford University Press (OUP)
Published
2015-09-13
Volume
19
Issue
4
Pages
pyv106
ISSN
  • 1461-1457 (ISSN-L)
  • 1469-5111
DOI
10.1093/ijnp/pyv106
PMC
PMC4851260
OpenAlex
W2284013959
Cited by
47
References
17
Citations by year
2026: 2 · 2025: 5 · 2024: 6 · 2023: 7 · 2022: 4 · 2021: 8 · 2020: 6 · 2019: 3 · 2018: 4 · 2017: 2
FWCI
0.20
Type
journal article
Language
en
Open access
Licence
cc-by-nc
Locations
  • The International Journal of Neuropsychopharmacology (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • HighWire Press Open Archive (submittedVersion)
Funders
Israel Science Foundation
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
Keywords
Eph receptors, ephrins, memory formation, synaptic plasticity, long-term memory, dendritic spine morphogenesis, glutamate receptor trafficking, presynaptic neurotransmitter release, Alzheimer's disease, anxiety
MeSH terms
Animals, Humans, Memory, Neurons, Receptors, Eph Family, Ephrins

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