Analysing the visible conformational substates of the FK506-binding protein FKBP12

Mustafi, Sourajit M.; Chen, Hui; Li, Hongmin; LeMaster, David M.; Hernández, Griselda

doi:10.1042/bj20130276

Analysing the visible conformational substates of the FK506-binding protein FKBP12

The 1H-15N 2D NMR correlation spectrum of the widely studied FK506-binding protein FKBP12 (FK506-binding protein of 12 kDa) contains previously unreported peak doublings for at least 31 residues that arise from a minor conformational state (12% of total) which exchanges with the major conformatio…