Differential conformational dynamics in the closely homologous FK506-binding domains of FKBP51 and FKBP52

Mustafi, Sourajit M.; LeMaster, David M.; Hernández, Griselda

doi:10.1042/bj20140232

Differential conformational dynamics in the closely homologous FK506-binding domains of FKBP51 and FKBP52

As co-chaperones of Hsp90 (heat-shock protein 90), FKBP51 (FK506-binding protein of 51 kDa) and FKBP52 (FK506-binding protein of 52 kDa) act as antagonists in regulating the hormone affinity and nuclear transport of steroid receptor complexes. Exchange of Leu119 in FKBP51 for Pro119 in FKBP52 has…