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The Chemosensitizing Role of Metformin in Anti-Cancer Therapy

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Metformin enhances protection in guinea pigs chronically infected with Mycobacterium tuberculosis

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Influence of metformin on HIF-1 pathway in multiple myeloma

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Metformin: Targeting the Metabolo-Epigenetic Link in Cancer Biology

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Targeting Cancer Metabolism and Current Anti-Cancer Drugs

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Diabetes, Metformin, and Lung Cancer: Retrospective Study of the Korean NHIS-HEALS Database

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Mitochondrial Metabolism in Pancreatic Ductal Adenocarcinoma: From Mechanism-Based Perspectives to Therapy

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Modified Metformin as a More Potent Anticancer Drug: Mitochondrial Inhibition, Redox Signaling, Antiproliferative Effects and Future EPR Studies

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A Structural Basis for Biguanide Activity

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Identification of the signals for glucose-induced insulin secretion in INS1 (832/13) β-cells using metformin-induced metabolic deceleration as a model

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Metformin Promotes the Protection of Mice Infected With Plasmodium yoelii Independently of γδ T Cell Expansion

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Metformin Results in Diametrically Opposed Effects by Targeting Non-Stem Cancer Cells but Protecting Cancer Stem Cells in Head and Neck Squamous Cell Carcinoma

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Novel Mitochondria-targeted Drugs for Cancer Therapy

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Mitochondrial Inhibition: a Treatment Strategy in Cancer?

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The cytotoxicity of gallium maltolate in glioblastoma cells is enhanced by metformin through combined action on mitochondrial complex 1

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Microbiome and oral squamous cell carcinoma: a possible interplay on iron metabolism and its impact on tumor microenvironment

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Metformin Decreases 2-HG Production through the MYC-PHGDH Pathway in Suppressing Breast Cancer Cell Proliferation

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Developmental phenotypic and transcriptomic effects of exposure to nanomolar levels of metformin in zebrafish

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Redox Homeostasis Involvement in the Pharmacological Effects of Metformin in Systemic Lupus Erythematosus

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Reactive oxygen species: Key players in the anticancer effects of apigenin?

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Genetics of enzymatic dysfunctions in metabolic disorders and cancer

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Differentiating the Pharmacodynamics and Toxicology of Macrolide and Ketolide Antibiotics

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The mitochondrial stress signaling tunes immunity from a view of systemic tumor microenvironment and ecosystem

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Targeting Mitochondrial Metabolism to Reverse Radioresistance: An Alternative to Glucose Metabolism

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Antioxidants and Therapeutic Targets in Ovarian Clear Cell Carcinoma

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Modulation of Oxidative Phosphorylation with IM156 Attenuates Mitochondrial Metabolic Reprogramming and Inhibits Pulmonary Fibrosis

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Time to Change: A Systems Pharmacology Approach to Disentangle Mechanisms of Drug-Induced Mitochondrial Toxicity

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HepatoDyn: A Dynamic Model of Hepatocyte Metabolism That Integrates 13C Isotopomer Data

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Effects of Biguanides on Growth and Glycolysis of Bladder and Colon Cancer Cells

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A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity

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The novel function of tumor protein D54 in regulating pyruvate dehydrogenase and metformin cytotoxicity in breast cancer

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Aglycemic growth enhances carbohydrate metabolism and induces sensitivity to menadione in cultured tumor-derived cells

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Metformin Potentiates the Anticancer Effect of Everolimus on Cervical Cancer In Vitro and In Vivo

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Pharmacological Approaches to Decelerate Aging: A Promising Path

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Increased susceptibility to pneumonia due to tumour necrosis factor inhibition and prospective immune system rescue via immunotherapy

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Metformin: A Promising Antidiabetic Medication for Cancer Treatment

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Lactate-Induced Glucose Output Is Unchanged by Metformin at a Therapeutic Concentration – A Mass Spectrometry Imaging Study of the Perfused Rat Liver

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Metformin Preconditioning Improves Hepatobiliary Function and Reduces Injury in a Rat Model of Normothermic Machine Perfusion and Orthotopic Transplantation

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Metformin and Cancer Glucose Metabolism: At the Bench or at the Bedside?

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The Association of Premorbid Metformin Exposure With Mortality and Organ Dysfunction in Sepsis: A Systematic Review and Meta-Analysis

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Hydroxylated Rotenoids Selectively Inhibit the Proliferation of Prostate Cancer Cells

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Metformin improves the therapeutic efficacy of low-dose albendazole against experimental alveolar echinococcosis

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Metformin extends the chronological lifespan of fission yeast by altering energy metabolism and stress resistance capacity

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The Discovery and Development of Thienopyrimidines as Inhibitors of Helicobacter pylori That Act through Inhibition of the Respiratory Complex I

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Metformin Induces Oxidative Stress-Mediated Apoptosis without the Blockade of Glycolysis in H4IIE Hepatocellular Carcinoma Cells

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Metformin inhibits mitochondrial complex I in intestinal epithelium to promote glycaemic control

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Spautin-1 inhibits mitochondrial complex I and leads to suppression of the unfolded protein response and cell survival during glucose starvation

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NDUFS3 knockout cancer cells and molecular docking reveal specificity and mode of action of anti-cancer respiratory complex I inhibitors

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NK cells vs. obesity: A tale of dysfunction & redemption

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Biomimetic nanovesicle co-delivery system impairs energy metabolism for cancer treatment

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Phenotypic and functional characteristics of murine CD11c+ B cells which is suppressed by metformin

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Advances in the Use of Metformin for Liver Disease

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Direct effects of phenformin on metabolism/bioenergetics and viability of SH‑SY5Y neuroblastoma cells

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Metformin use reduced the risk of stomach cancer in diabetic patients in Korea: an analysis of Korean NHIS-HEALS database

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Is metformin a geroprotector? A peek into the current clinical and experimental data

Zajda, A., Huttunen, K. M., Sikora, J., Podsiedlik, M., & Markowicz-Piasecka, M. (2020) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2020.111350 · Cited by 16

Metformin reduces total microparticles and microparticles-expressing tissue factor in women with polycystic ovary syndrome

Carvalho, L. M. L., Ferreira, C. N., Cândido, A. L., dos Reis, F. M., Sóter, M. O., Sales, M. F., Silva, I. D. F. O., Nunes, F. F. C., & Gomes, K. B. (2017) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-017-4471-0 · Cited by 16

Respiromics – An integrative analysis linking mitochondrial bioenergetics to molecular signatures

Walheim, E., Wiśniewski, J. R., & Jastroch, M. (2018) · Molecular Metabolism · doi:10.1016/j.molmet.2018.01.002 · Cited by 16

Interplay between ShcA Signaling and PGC-1α Triggers Targetable Metabolic Vulnerabilities in Breast Cancer

Im, Y. K., Najyb, O., Gravel, S., McGuirk, S., Ahn, R., Avizonis, D. Z., Chénard, V., Sabourin, V., Hudson, J., Pawson, T. J., et al. (2018) · Cancer Research · doi:10.1158/0008-5472.can-17-3696 · Cited by 17

Rerouting the drug response: Overcoming metabolic adaptation in KRAS-mutant cancers

Moss, D., McCann, C. K., & Kerr, E. M. (2022) · Science Signaling · doi:10.1126/scisignal.abj3490 · Cited by 16

A New Quinone-Based Inhibitor of Mitochondrial Complex I in D-Conformation, Producing Invasion Reduction and Sensitization to Venetoclax in Breast Cancer Cells

Monroy-Cárdenas, M., Andrades, V., Almarza, C., Vera, M. J., Martı́nez, J., Pulgar, R., Amalraj, J., Araya‐Maturana, R., & Urra, F. A. (2023) · Antioxidants · doi:10.3390/antiox12081597 · Cited by 15

Vitamin B12 Deficiency in Patients Taking Metformin: Pathogenesis and Recommendations

Ramzan, N. U. H., Shahjahan, K., Dhillon, R. A., Khan, N. T. A., Hashmat, M. B., Anwer, M. U., Ahmed, D., Afzal, F., Tahir, M. M., & Muzaffar, A. (2024) · Cureus · doi:10.7759/cureus.68550 · Cited by 19

The Pituitary Gland is a Novel Major Site of Action of Metformin in Non-Human Primates: a Potential Path to Expand and Integrate Its Metabolic Actions

Vazquez-Borrego, M. C., Fuentes-Fayos, A. C., Gahete, M. D., Castano, J. P., Kineman, R. D., & Luque, R. M. (2018) · Cellular Physiology and Biochemistry · doi:10.1159/000493448 · Cited by 15

When Anti-Aging Studies Meet Cancer Chemoprevention: Can Anti-Aging Agent Kill Two Birds with One Blow?

Yokoyama, N. N., Denmon, A. P., Uchio, E., Jordan, M. L., Mercola, D., & Zi, X. (2015) · Current Pharmacology Reports · doi:10.1007/s40495-015-0039-5 · Cited by 15

Four key questions about metformin and cancer

Chandel, N. S. (2014) · BMC Biology · doi:10.1186/s12915-014-0085-1 · Cited by 16

Oncogenic kinases and perturbations in protein synthesis machinery and energetics in neoplasia

Uchenunu, O., Pollak, M., Topisirović, I., & Hulea, L. (2018) · Journal of Molecular Endocrinology · doi:10.1530/jme-18-0058 · Cited by 16

The anti-cancer effects of phenformin in thyroid cancer cell lines and in normal thyrocytes

Coperchini, F., Croce, L., Denegri, M., Awwad, O., Ngnitejeu, S. T., Magri, F., Chiovato, L., & Rotondi, M. (2019) · Oncotarget · doi:10.18632/oncotarget.27266 · Cited by 15

Metformin improves blood glucose by increasing incretins independent of changes in gluconeogenesis in youth with type 2 diabetes

Cravalho, C. K. L., Meyers, A. G., Mabundo, L. S., Courville, A. B., Yang, S. B., Cai, H., Dai, Y., Walter, M. F., Walter, P. J., Sharma, S., et al. (2020) · Diabetologia · doi:10.1007/s00125-020-05236-y · Cited by 17

Metformin: still the sweet spot for CV protection in diabetes?

Rena, G., Mordi, I. R., & Lang, C. C. (2020) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2020.10.018 · Cited by 15

Reprogramming of glucose metabolism in pancreatic cancer: mechanisms, implications, and therapeutic perspectives

Zhang, Y., Li, W., Niu, J., Fan, Z., Li, X., & Zhang, H. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1586959 · Cited by 15

Metformin promotes susceptibility to experimental Leishmania braziliensis infection

Lima, F. R., Ferreira, L. D. M., Malta, T. A., Bonyek-Silva, Í., Santos, R. L., Tavares, N. M., Filho, E. M. D. C., & Arruda, S. M. (2020) · Memórias do Instituto Oswaldo Cruz · doi:10.1590/0074-02760200272 · Cited by 14

Metformin Perturbs Pancreatic Differentiation From Human Embryonic Stem Cells

Nguyen, L. T. V., Lim, L. Y., Ding, S. S. L., Amirruddin, N. S., Hoon, S. S., Chan, S., & Teo, A. K. K. (2021) · Diabetes · doi:10.2337/db20-0722 · Cited by 17

Directly Reprogrammed Human Neurons to Understand Age‐Related Energy Metabolism Impairment and Mitochondrial Dysfunction in Healthy Aging and Neurodegeneration

Gudenschwager, C., Chavez, I., Cárdenas, C., & González-Billault, C. E. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/5586052 · Cited by 12

Identification of 4-N-[2-(4-phenoxyphenyl)ethyl]quinazoline-4,6-diamine as a novel, highly potent and specific inhibitor of mitochondrial complex I

Krishnathas, R., Bonke, E., Dröse, S., Zickermann, V., & Nasiri, H. R. (2017) · MedChemComm · doi:10.1039/c6md00655h · Cited by 14

Clusterin inhibits Cr(VI)-induced apoptosis via enhancing mitochondrial biogenesis through AKT-associated STAT3 activation in L02 hepatocytes

Liang, N., Li, S., Liang, Y., Ma, Y., Tang, S., Ye, S., & Xiao, F. (2021) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2021.112447 · Cited by 14

Metabolic gatekeeper ACAD9 coordinates linoleic acid metabolism and redox homeostasis via mitochondrial complex I to drive ovarian cancer progression

Li, J., Shi, J., Ding, J., Qu, W., Lv, J., Bai, Y., Wang, S. Q., Zhou, R., Chen, Y., Liu, Y., et al. (2025) · Cancer Letters · doi:10.1016/j.canlet.2025.217903 · Cited by 13

Multidrug and toxin extrusion 1 and human organic cation transporter 1 polymorphisms in patients with castration-resistant prostate cancer receiving metformin (SAKK 08/09)

Joerger, M., van Schaik, R. H. N., Becker, M. L., Hayoz, S., Pollak, M., Cathomas, R. L., Winterhalder, R., Gillessen, S., & Rothermundt, C. A. (2015) · Prostate Cancer and Prostatic Diseases · doi:10.1038/pcan.2015.8 · Cited by 13

Mitochondrial DNA Somatic Mutation in Cancer

Kim, A. (2014) · Toxicological Research · doi:10.5487/tr.2014.30.4.235 · Cited by 13

First-in-Class NADH/Ubiquinone Oxidoreductase Core Subunit S7 (NDUFS7) Antagonist for the Treatment of Pancreatic Cancer

Xu, Y., Xue, D., Kyani, A., Bankhead, A., Roy, J., Ljungman, M. E., & Neamati, N. (2023) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.3c00069 · Cited by 15

Pleiotropic Effects of Biguanides on Mitochondrial Reactive Oxygen Species Production

Pecinová, A., Drahota, Z., Kovalcikova, J., Kovářová, N., Pecina, P., Alán, L., Zima, M., Houštěk, J., & Mráček, T. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/7038603 · Cited by 27

Selective Inhibition of Deactivated Mitochondrial Complex I by Biguanides

Matsuzaki, S., & Humphries, K. M. (2015) · Biochemistry · doi:10.1021/bi501473h · Cited by 81

Abstract 1126: Differential effects of metformin and phenformin vs. other complex 1 inhibitors in vitro and in vivo

Algire, C., Ehrmann, A., Christian, S., Neuhaus, R., Menz, S., Schwede, W., Haerter, M., & Haegebarth, A. (2015) · Cancer Research · doi:10.1158/1538-7445.am2015-1126 · Cited by 2

Metformin selectively targets redox control of complex I energy transduction

Cameron, A., Logie, L., Patel, K., Erhardt, S., Bacon, S., Middleton, P. K., Harthill, J. E., Forteath, C., Coats, J. T., Kerr, C., et al. (2017) · Redox Biology · doi:10.1016/j.redox.2017.08.018 · Cited by 154

Biguanide MC001, a Dual Inhibitor of OXPHOS and Glycolysis, Shows Enhanced Antitumor Activity Without Increasing Lactate Production

Fu, J., Liu, S., Hu, M., Liao, X., Wang, X., Xu, Z., Li, Q., & Quan, J. (2022) · ChemMedChem · doi:10.1002/cmdc.202100674 · Cited by 9