The DOI matches its Crossref record.
Cell killing and DNA damage by hydrogen peroxide are mediated by intracellular iron
Open accessAbstract
Phenanthroline, a strong iron chelator, prevents both the formation of DNA single-strand breaks and the killing of mouse cells produced by H2O2. These results, taken together with our previous findings, indicate that the DNA damage is produced by hydroxyl radicals formed when H2O2 reacts with chromatin-bound Fe2+ and that this damage is responsible for the killing effect.
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Citations
Cited by
[1] Role of free radicals and catalytic metal ions in human disease: An overview
Halliwell, B., & Gutteridge, J. M. C. (1990) · Methods in Enzymology · doi:10.1016/0076-6879(90)86093-b · Cited by 4,994
Oxygen free radicals and iron in relation to biology and medicine: Some problems and concepts
Halliwell, B., & Gutteridge, J. M. C. (1986) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(86)90305-x · Cited by 2,038
Oxygen radicals and human disease
CROSS, C. E., HALLIWELL, B., BORISH, E. T., PRYOR, W. A., AMES, B. N., SAUL, R. L., McCORD, J. M., & HARMAN, D. (1987) · Annals of Internal Medicine · doi:10.7326/0003-4819-107-4-526 · Cited by 1,856
Role of oxidative stress in female reproduction
Agarwal, A., Gupta, S., & Sharma, R. K. (2005) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-3-28 · Cited by 1,729
DNA damage by oxygen‐derived species Its mechanism and measurement in mammalian systems
Halliwell, B., & Aruoma, O. I. (1991) · FEBS Letters · doi:10.1016/0014-5793(91)80347-6 · Cited by 1,537
Metadata
- Authors
- Mello Filho, A. C., Hoffmann, M. E., & Meneghini, R.
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 1984-02-15
- Volume
- 218
- Issue
- 1
- Pages
- 273-275
- ISSN
- 0264-6021 (ISSN-L)
- 1470-8728
- OpenAlex
- W2216471839
- Cited by
- 333
- References
- 0
- FWCI
- 4.59
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Mello Filho, A. C., Hoffmann, M. E., & Meneghini, R. (1984). Cell killing and DNA damage by hydrogen peroxide are mediated by intracellular iron. Biochemical Journal. https://doi.org/10.1042/bj2180273
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
