Cited by 551Neutrophil, Myeloperoxidase and Oxidative MechanismsRedox biology and oxidative stressBioactive Compounds and Antitumor Agents

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The effect of the inhibitor diphenylene iodonium on the superoxide-generating system of neutrophils. Specific labelling of a component polypeptide of the oxidase

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Cross, A R, Jones, O T G·1986·Biochemical Journal

DOI 10.1042/bj2370111PMC PMC1146954

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Abstract

NADPH-dependent superoxide production by the solubilized oxidase of neutrophils was inhibited 36% by diphenylene iodonium at a 1:1 stoichiometry with the enzyme flavoprotein content. Addition of diphenylene iodonium strongly inhibited the NADPH-dependent reduction of both FAD and cytochrome b-245 in steady-state kinetic experiments. Incubation of solubilized enzyme with diphenylene [125I]iodonium resulted in the specific labelling of a polypeptide of Mr 45,000. In the presence of NADPH the amount of label incorporated into the polypeptide was reduced. There was no difference in labelling between enzyme prepared from stimulated or unstimulated cells.

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Authors: Cross, A. R., & Jones, O. T. G.
Affiliations: University of Bristol (GB)
ORCID: Jones, O T G
Venue: Biochemical Journal
Publisher: Portland Press Ltd.
Published: 1986-07-01
Volume: 237
Issue: 1
Pages: 111-116
ISSN: 0264-6021 (ISSN-L)
1470-8728
DOI: 10.1042/bj2370111
PMC: PMC1146954
OpenAlex: W1801129364
Cited by: 551
References: 22
Citations by year: 2026: 2 · 2025: 5 · 2024: 1 · 2023: 5 · 2022: 7 · 2021: 5 · 2020: 9 · 2019: 12 · 2018: 13 · 2017: 14 · 2016: 9 · 2015: 13 · 2014: 9 · 2013: 19 · 2012: 20
FWCI: 5.47
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Biochemical Journal (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Medical Research Council
Topics: Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Bioactive Compounds and Antitumor Agents
Keywords: diphenyleneiodonium, neutrophil NADPH oxidase, superoxide production, flavoprotein, enzyme inhibition, FAD reduction, NADPH-dependent reduction, respiratory burst
MeSH terms: Animals, Electrophoresis, Polyacrylamide Gel, NADH, NADPH Oxidoreductases, NADP, Neutrophils, Onium Compounds, Protein Binding, Swine, NADPH Oxidases, In Vitro Techniques

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The effect of the inhibitor diphenylene iodonium on the superoxide-generating system of neutrophils. Specific labelling of a component polypeptide of the oxidase

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