Amino acid metabolism in tumour-bearing mice

Rivera, S; Azcón-Bieto, J; López-Soriano, F J; Miralpeix, M; Argilés, J M

doi:10.1042/bj2490443

Cited by 76Amino Acid Enzymes and MetabolismCancer, Hypoxia, and MetabolismCancer and biochemical research

Amino acid metabolism in tumour-bearing mice

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Rivera, S, Azcón-Bieto, J, López-Soriano, F J, Miralpeix, M, Argilés, J M·1988·Biochemical Journal

DOI 10.1042/bj2490443PMC PMC1148723

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Abstract

Mice bearing the Lewis lung carcinoma showed a high tumour glutaminase activity and significantly higher concentrations of most amino acids than in both the liver and the skeletal muscle of the host. Tumour tissue slices showed a marked preference for glutamine, especially for oxidation of its skeleton to CO2. It is proposed that the metabolism of this particular carcinoma is focused on amino acid degradation, glutamine being its preferred substrate.

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Numerous tumorigenic contexts are associated with depletion of glutamine from the tumor environment compared to normal tissue.
“numerous tumorigenic contexts are associated with the depletion of glutamine from the tumor environment as compared to the corresponding normal tissue”
From The emerging hallmarks of cancer metabolism (2016) · cites this paper as Rivera et al., 1988

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Authors: Rivera, S., Azcón-Bieto, J., López-Soriano, F. J., Miralpeix, M., & Argilés, J. M.
Affiliations: Universitat de Barcelona (ES)
Department de Bioquímica i Fisiologia, Unitat de Bioquímica i Biologia Molecular B, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, 08071 Barcelona, Spain
ORCID: Rivera, S
López-Soriano, F J
Argilés, J M
Venue: Biochemical Journal
Publisher: Portland Press Ltd.
Published: 1988-01-15
Volume: 249
Issue: 2
Pages: 443-449
ISSN: 0264-6021 (ISSN-L)
1470-8728
DOI: 10.1042/bj2490443
PMC: PMC1148723
OpenAlex: W1944722283
Cited by: 76
References: 30
Citations by year: 2026: 2 · 2025: 4 · 2024: 3 · 2023: 1 · 2022: 2 · 2021: 4 · 2020: 2 · 2019: 3 · 2018: 3 · 2017: 2 · 2016: 1 · 2015: 3 · 2014: 1 · 2013: 3 · 2012: 2
FWCI: 1.52
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Biochemical Journal (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
Keywords: amino acid metabolism, Lewis lung carcinoma, tumor-bearing mice, glutaminase activity, glutamine oxidation, cancer metabolism, amino acid catabolism, skeletal muscle, liver
MeSH terms: Amino Acids, Animals, Carcinoma, Squamous Cell, Glucose, Glutaminase, Liver, Lung Neoplasms, Mice, Inbred C57BL, Muscles, Neoplasm Transplantation, Proteins, Lipid Metabolism, Mice

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Amino acid metabolism in tumour-bearing mice

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