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The mechanism of initiation of lipid peroxidation. Evidence against a requirement for an iron(II)-iron(III) complex
Open accessAbstract
When Fe2+ ions are added to rat-liver microsomes, lipid peroxidation begins after a short lag period. Fe2+-dependent peroxidation in the first few minutes of the incubation can be increased by adding Fe3+, ascorbic acid or Pb2+ ions; these stimulations are not additive. By contrast, Pb2+ ions inhibit peroxidation of microsomes in the presence of Fe3+/ascorbate or Fe3+-ADP/NADPH. In liposomes made from ox-brain phospholipids, Fe2+-dependent peroxidation is stimulated slightly by Fe3+, but much more so by ascorbic acid, Al3+ or Pb2+; these stimulations are not additive. Liposomal peroxidation in the presence of Fe3+/ascorbate is inhibited by Pb2+ or Al3+. These results argue against the participation of an Fe2+-Fe3+-O2 complex, or a critical 1:1 ratio of Fe2+ to Fe3+, in the initiation of lipid peroxidation in liposomes and rat-liver microsomes.
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Citations
Cited by
[1] Role of free radicals and catalytic metal ions in human disease: An overview
Halliwell, B., & Gutteridge, J. M. C. (1990) · Methods in Enzymology · doi:10.1016/0076-6879(90)86093-b · Cited by 4,994
Self-citationReactive Oxygen Species and the Central Nervous System
Halliwell, B. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb10990.x · Cited by 2,947
Self-citationLipid peroxidation: its mechanism, measurement, and significance
Halliwell, B., & Chirico, S. (1993) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/57.5.715s · Cited by 2,352
Self-citationPhenolic compounds and their role in oxidative processes in fruits
Robards, K., Prenzler, P. D., Tucker, G., Swatsitang, P., & Glover, W. (1999) · Food Chemistry · doi:10.1016/s0308-8146(99)00093-x · Cited by 1,277
Bianchi, P., Kunduzova, O., Masini, E., Cambon, C., Bani, D., Raimondi, L., Seguelas, M.-H., Nistri, S., Colucci, W., Leducq, N., et al. (2005) · Circulation · doi:10.1161/circulationaha.104.528133 · Cited by 264
Metadata
- Authors
- Aruoma, O. I., Halliwell, B., Laughton, M. J., Quinlan, G. J., & Gutteridge, J. M. C.
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 1989-03-01
- Volume
- 258
- Issue
- 2
- Pages
- 617-620
- ISSN
- 0264-6021 (ISSN-L)
- 1470-8728
- OpenAlex
- W1834815794
- Cited by
- 210
- References
- 0
- FWCI
- 10.02
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: The mechanism of initiation of lipid peroxidation. Evidence against a requirement for an iron(II)-iron(III) complex. https://app.cochat.ai/papers/10.1042/bj2580617
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- Aruoma, O. I., Halliwell, B., Laughton, M. J., Quinlan, G. J., & Gutteridge, J. M. C. (1989). The mechanism of initiation of lipid peroxidation. Evidence against a requirement for an iron(II)-iron(III) complex. Biochemical Journal. https://doi.org/10.1042/bj2580617
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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