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The action of defined oxygen-centred free radicals on human low-density lipoprotein
Open accessAbstract
The effects of defined oxygen-centred free radicals on human low-density lipoprotein (LDL) structure and receptor affinity are discussed in relation to the mechanisms of cell-mediated oxidative modification of LDL. Both hydroxyl (OH.) and hydroperoxyl (HO2.) radicals caused depletion of endogenous alpha-tocopherol and formation of hydroperoxides. Superoxide (O2-.) radicals produced only very limited oxidation, but could potentiate oxidation stimulated by the addition of Cu2+. All these radicals enhanced the net negative charge of intact LDL and induced fragmentation of apolipoprotein B-100 (apo B). OH. also caused cross-linking of apo B. Radical attack decreased the affinity of LDL for the fibroblast apo B/E receptor, but did not enhance its endocytosis by mouse macrophages.
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Cited by
[1] Role of free radicals and catalytic metal ions in human disease: An overview
Halliwell, B., & Gutteridge, J. M. C. (1990) · Methods in Enzymology · doi:10.1016/0076-6879(90)86093-b · Cited by 4,994
Free Radicals: Properties, Sources, Targets, and Their Implication in Various Diseases
Phaniendra, A., Jestadi, D. B., & Periyasamy, L. (2015) · Indian Journal of Clinical Biochemistry · doi:10.1007/s12291-014-0446-0 · Cited by 2,886
Obstructive sleep apnoea and its cardiovascular consequences
Bradley, T. D., & Floras, J. S. (2009) · The Lancet · doi:10.1016/s0140-6736(08)61622-0 · Cited by 1,385
Retsky, K. L., Freeman, M. W., & Frei, B. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54075-8 · Cited by 271
Association of ceramides in human plasma with risk factors of atherosclerosis
Ichi, I., Nakahara, K., Miyashita, Y., Hidaka, A., Kutsukake, S., Inoue, K., Maruyama, T., Miwa, Y., Harada‐Shiba, M., Tsushima, M., et al. (2006) · Lipids · doi:10.1007/s11745-006-5041-6 · Cited by 96
Metadata
- Authors
- Bedwell, S., Dean, R. T., & Jessup, W.
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 1989-09-15
- Volume
- 262
- Issue
- 3
- Pages
- 707-712
- ISSN
- 0264-6021 (ISSN-L)
- 1470-8728
- OpenAlex
- W2125570349
- Cited by
- 167
- References
- 0
- FWCI
- 7.71
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Bedwell, S., Dean, R. T., & Jessup, W. (1989). The action of defined oxygen-centred free radicals on human low-density lipoprotein. Biochemical Journal. https://doi.org/10.1042/bj2620707
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
