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Hepatic iodothyronine 5′-deiodinase. The role of selenium
Open accessAbstract
Selenium (Se) deficiency decreased by 8-fold the activity of type 1 iodothyronine 5′-deiodinase (ID-I) in hepatic microsomal fractions from rats. Solubilized hepatic microsomes from rats injected with 75Se-labelled Na2SeO3 4 days before killing were found by chromatography on agarose gels to contain a 75Se-containing fraction with ID-I activity. PAGE of this fraction under reducing conditions, followed by autoradiography, revealed a single 75Se-containing protein (Mr 27,400 +/- 300). This protein could also be labelled with 125I-bromoacetyl reverse tri-iodothyronine, an affinity label for ID-I. The results suggest that hepatic ID-I is a selenoprotein or has an Se-containing subunit essential for activity.
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Citations
Cited by
Bianco, A. C., Salvatore, D., Gereben, B., Berry, M. J., & Larsen, P. R. (2002) · Endocrine Reviews · doi:10.1210/edrv.23.1.0455 · Cited by 1,853
Combs, G. F., & Gray, W. P. (1998) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(98)00014-x · Cited by 668
The Deiodinase Family of Selenoproteins
GERMAIN, D. L. S., & GALTON, V. A. (1997) · Thyroid · doi:10.1089/thy.1997.7.655 · Cited by 342
Selenium metabolism and bioavailability
Daniels, L. A. (1996) · Biological Trace Element Research · doi:10.1007/bf02784430 · Cited by 306
Köhrle, J. (2015) · Current Opinion in Endocrinology, Diabetes & Obesity · doi:10.1097/med.0000000000000190 · Cited by 195
Metadata
- Authors
- Arthur, J. R., Nicol, F., & Beckett, G. J.
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 1990-12-01
- Volume
- 272
- Issue
- 2
- Pages
- 537-540
- ISSN
- 0264-6021 (ISSN-L)
- 1470-8728
- OpenAlex
- W2215298876
- Cited by
- 258
- References
- 0
- FWCI
- 15.89
- Type
- journal article
- Language
- en
- Open access
- bronze
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