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Cited by 195Selenium in Biological SystemsThyroid Disorders and TreatmentsTrace Elements in Health

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Selenium and the thyroid

Köhrle, Josef·2015·Current Opinion in Endocrinology, Diabetes & Obesity
DOI 10.1097/med.0000000000000190
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Abstract

PURPOSE OF REVIEW: This article provides an update on the role of the essential trace element selenium and its interaction with the other trace elements iodine and iron that together contribute to adequate thyroid hormone status. Synthesis, secretion, metabolism and action of thyroid hormone in target tissues depend on a balanced nutritional availability or supplementation of these elements. Selenium status is altered in benign and malignant thyroid diseases and various selenium compounds have been used to prevent or treat widespread diseases such as goiter, autoimmune thyroid disease or thyroid cancer. RECENT FINDINGS: Several studies, most with still too low numbers of cases, indicate that selenium administration in both autoimmune thyroiditis (Hashimoto thyroiditis) and mild Graves' disease improves clinical scores and well-being of patients and reduces thyroperoxidase antibody titers. However, published results are still conflicting depending on basal selenium status, dose, time and form of selenium used for intervention. Evidence for sex-specific selenium action, lack of beneficial effects in pregnancy and contribution of genetic polymorphisms (selenoprotein S) has been presented. SUMMARY: Adequate nutritional supply of selenium that saturates expression of circulating selenoprotein P, together with optimal iodine and iron intake, is required for a healthy and functional thyroid during development, adolescence, adulthood and aging.

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Metadata

Authors
Köhrle, J.
Affiliations
Charité – Universitätsmedizin Berlin (DE)
Corresponding author
Köhrle, Josef
ORCID
Köhrle, Josef
Venue
Current Opinion in Endocrinology, Diabetes & Obesity
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2015-10
Volume
22
Issue
5
Pages
392-401
ISSN
1752-296X (ISSN-L)
DOI
10.1097/med.0000000000000190
OpenAlex
W2328618770
Cited by
195
References
156
Citations by year
2026: 11 · 2025: 10 · 2024: 18 · 2023: 16 · 2022: 23 · 2021: 22 · 2020: 19 · 2019: 17 · 2018: 14 · 2017: 15 · 2016: 14 · 2015: 5
FWCI
2.04
Type
journal article
Language
en
Open access
closed
Locations
  • Current Opinion in Endocrinology Diabetes and Obesity (publishedVersion)
  • PubMed (publishedVersion)
Funders
Deutsche Forschungsgemeinschaft
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Selenium in Biological Systems
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
Keywords
selenium, thyroid gland, iodine, iron, thyroid hormones, selenium supplementation, Hashimoto's thyroiditis, Graves' disease, autoimmune thyroid disease, thyroid cancer, goiter, thyroid peroxidase antibodies, selenoprotein P, selenoprotein S, genetic polymorphism, sex differences, pregnancy, trace elements
MeSH terms
Humans, Nutritional Status, Selenium, Thyroid Diseases, Thyroid Gland, Selenoprotein P

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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