Long-lived reactive species on free-radical-damaged proteins
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We have demonstrated two novel reactive species on radical-modified proteins which are relatively long-lived, one oxidizing and one reducing. The two species are reactive with critical biological components, and so may be of physiological and pathological importance. The oxidizing species, which have been identified as protein hydroperoxides, can consume key cellular reductants, such as ascorbate and glutathione. The reducing species can act on both free and metalloprotein forms of copper and iron ions, which participate in radical generation. These findings suggest that proteins may act as traps for the chemical energy released by free radicals, with the capacity to pass it on to other molecules. The long-lived nature of both the reactive moieties indicates that they may be able to diffuse and transfer damaging reactions to distant sites.
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Under normal circumstances, the biological system releases an enzyme, superoxide dismutase SOD, which specifically maintains the O2 concentration at an optimal level of 10-10 M.
“Under normal circumstances, the biological system releases an enzyme, superoxide dismutase SOD, which specifically maintains the O2 concentration at an optimal level of 10–10 M [68].”
From Superoxide Anion Chemistry—Its Role at the Core of the Innate Immunity (2023) · cites this paper as [68]
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Cellular effects of peptide and protein hydroperoxides
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- Authors
- Simpson, J. A., Narita, S., Gieseg, S., Gebicki, S., Gebicki, J. M., & Dean, R. T.
- Affiliations
- The Heart Research Institute (AU)
- Macquarie University (AU)
- Corresponding author
- Gieseg, S
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 1992-03-15
- Volume
- 282
- Issue
- 3
- Pages
- 621-624
- ISSN
- 0264-6021 (ISSN-L)
- 1470-8728
- PMC
- PMC1130831
- OpenAlex
- W2404844012
- Cited by
- 225
- References
- 23
- Citations by year
- 2026: 2 · 2025: 4 · 2023: 5 · 2021: 6 · 2019: 5 · 2018: 2 · 2017: 5 · 2016: 7 · 2015: 4 · 2014: 7 · 2013: 8 · 2012: 9
- FWCI
- 4.10
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Biochemical Journal (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Heart Research Institute
- Medical Research Council
- Australian Research Council
- National Health and Medical Research Council
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Physical Sciences › Chemistry › Organic Chemistry › Free Radicals and Antioxidants
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Keywords
- reactive oxygen species, vitamin C, glutathione, copper ions, iron ions, metalloproteins, free radical generation, energy transfer, protein oxidation
- MeSH terms
- Amino Acids, Free Radicals, Metals, Oxidation-Reduction, Peroxides, Proteins
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