The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Angiotensin I-converting enzyme in human circulating mononuclear cells: genetic polymorphism of expression in T-lymphocytes
Open accessAbstract
The expression of angiotensin-I converting enzyme (ACE; EC 3.4.15.1) in human circulating mononuclear cells was studied. T-lymphocytes contained the highest level of enzyme, approx. 28 times more per cell than monocytes. No activity was detected in B-lymphocytes. ACE was present mainly in the microsomal fraction, where it was found to be the major membrane-bound bradykinin-inactivating enzyme. An mRNA for ACE was detected and characterized after reverse transcription and amplification by PCR in T-lymphocytes and several T-cell leukaemia cell lines. We have previously observed that the interindividual variability in the levels of ACE in plasma is, in part, genetically determined and influenced by an insertion/deletion polymorphism of the ACE gene. To investigate the mechanisms involved in the regulation of ACE biosynthesis, the ACE levels of T-lymphocytes from 35 healthy subjects having different ACE genotypes were studied. These levels varied widely between individuals but were highly reproducible and influenced by the polymorphism of the ACE gene. T-lymphocyte levels of ACE were significantly higher in subjects who were homozygote for the deletion than in the other subjects. These results show that ACE is expressed in T-lymphocytes and indicate that the level of ACE expression in cells synthesizing the enzyme is genetically determined.
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Cites
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Cited by
Marshall, R. P., Webb, S., Bellingan, G. J., Montgomery, H. E., Chaudhari, B., McAnulty, R. J., Humphries, S. E., Hill, M. R., & Laurent, G. J. (2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.2108086 · Cited by 412
[18] Peptidyl dipeptidase A: Angiotensin I-converting enzyme
Corvol, P., Williams, T. A., & Soubrier, F. (1995) · Methods in Enzymology · doi:10.1016/0076-6879(95)48020-x · Cited by 277
Benetos, A., Gautier, S., Ricard, S., Topouchian, J., Asmar, R., Poirier, O., Larosa, E., Guize, L., Safar, M., Soubrier, F., et al. (1996) · Circulation · doi:10.1161/01.cir.94.4.698 · Cited by 271
Regulation of T-cell function by endogenously produced angiotensin II
Hoch, N. E., Guzik, T. J., Chen, W., Deans, T., Maalouf, S. A., Gratze, P., Weyand, C., & Harrison, D. G. (2009) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.90521.2008 · Cited by 262
The ACE Gene and Human Performance: 12 Years On
Puthucheary, Z., Skipworth, J. R. A., Rawal, J., Loosemore, M., Van Someren, K., & Montgomery, H. E. (2011) · Sports Medicine · doi:10.2165/11588720-000000000-00000 · Cited by 220
Metadata
- Authors
- Costerousse, O., Allegrini, J., Lopez, M., & Alhenc-Gelas, F.
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 1993-02-15
- Volume
- 290
- Issue
- 1
- Pages
- 33-40
- ISSN
- 0264-6021 (ISSN-L)
- 1470-8728
- OpenAlex
- W48031782
- Cited by
- 507
- References
- 40
- FWCI
- 19.29
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Costerousse, O., Allegrini, J., Lopez, M., & Alhenc-Gelas, F. (1993). Angiotensin I-converting enzyme in human circulating mononuclear cells: genetic polymorphism of expression in T-lymphocytes. Biochemical Journal. https://doi.org/10.1042/bj2900033
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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