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Effect of Neuropeptides on Production of Inflammatory Cytokines by Human Monocytes
Abstract
Two groups of mediators, the neuropeptides substance P and K and the monocyte-derived cytokines, interact in the neural regulation of immunological and inflammatory responses. Substance P, substance K, and the carboxyl-terminal peptide SP(4-11) induce the release of interleukin-1, tumor necrosis factor-α, and interleukin-6 from human blood monocytes. The neuropeptide effects occur at low doses, are specific as shown by inhibition studies with a substance P antagonist, and require de novo protein synthesis. Since monocyte-derived cytokines regulate multiple cellular functions in inflammation and immunity and since neuropeptides can be released from peripheral nerve endings into surrounding tissues, these findings identify a potent mechanism for nervous system regulation of host defense responses.
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Cited by
Immune-neuro-endocrine interactions: facts and hypotheses.
BESEDOVSKY, H. O., & REY, A. D. (1996) · Endocrine Reviews · doi:10.1210/edrv-17-1-64 · Cited by 1,564
Neural regulation of innate immunity: a coordinated nonspecific host response to pathogens
Sternberg, E. M. (2006) · Nature Reviews Immunology · doi:10.1038/nri1810 · Cited by 1,064
Stress Hormones, Proinflammatory and Antiinflammatory Cytokines, and Autoimmunity
ELENKOV, I. J., & CHROUSOS, G. P. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04229.x · Cited by 983
Rosenkranz, M. A., Davidson, R. J., MacCoon, D. G., Sheridan, J. F., Kalin, N. H., & Lutz, A. (2013) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2012.10.013 · Cited by 307
Elenkov, I. J. (2008) · Neurochemistry International · doi:10.1016/j.neuint.2007.06.037 · Cited by 273
Metadata
- Authors
- Lotz, M., Vaughan, J. H., & Carson, D. A.
- Venue
- Science
- Published
- 1988-09-02
- Volume
- 241
- Issue
- 4870
- Pages
- 1218-1221
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2073645604
- Cited by
- 915
- References
- 0
- FWCI
- 12.98
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lotz, M., Vaughan, J. H., & Carson, D. A. (1988). Effect of Neuropeptides on Production of Inflammatory Cytokines by Human Monocytes. Science. https://doi.org/10.1126/science.2457950
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