Physiological control of metabolic flux: the requirement for multisite modulation

Positional cloning of the mouse obese gene and its human homologue

Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419 · see citing works

The control of flux.

KACSER, H., & Ja, B. (1973) · PubMed · Cited by 1,452 · see citing works

A Linear Steady-State Treatment of Enzymatic Chains. General Properties, Control and Effector Strength

Heinrich, R., & Rapoport, T. A. (1974) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1974.tb03318.x · Cited by 1,400 · see citing works

Metabolic control analysis: a survey of its theoretical and experimental development

Fell, D. A. (1992) · Biochemical Journal · doi:10.1042/bj2860313 · Cited by 782 · see citing works

Amino Acid Biosynthesis and its Regulation

Umbarger, H. E. (1978) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.47.070178.002533 · Cited by 744 · see citing works

Adaptive Characteristics of Urea Cycle Enzymes in the Rat

SCHIMKE, R. T. (1962) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)93943-8 · Cited by 735 · see citing works

Physiological and molecular mechanisms involved in nutritional regulation of fatty acid synthesis

Hillgartner, F. B., Salati, L. M., & Goodridge, A. G. (1995) · Physiological Reviews · doi:10.1152/physrev.1995.75.1.47 · Cited by 459 · see citing works

Overproduction of glycolytic enzymes in yeast

Schaaff, I., Heinisch, J. X., & Zimmermann, F. K. (1989) · Yeast · doi:10.1002/yea.320050408 · Cited by 303 · see citing works

Regulation of Metabolism in Working Muscle in Vivo

Sacktor, B., & Wormser-Shavit, E. (1966) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)96883-3 · Cited by 217 · see citing works

Synchronous behavior pattern of key glycolytic enzymes: Glucokinase, phosphofructokinase, and pyruvate kinase

Weber, G., Singhal, R. L., Stamm, N. B., Lea, M. A., & Fisher, E. A. (1966) · Advances in Enzyme Regulation · doi:10.1016/0065-2571(66)90007-0 · Cited by 193 · see citing works

A universal method for achieving increases in metabolite production

KACSER, H., & Acerenza, L. (1993) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1993.tb18153.x · Cited by 177 · see citing works

Hepatic Gluconeogenesis/Glycolysis: Regulation And Structure/Function Relationships Of Substrate Cycle Enzymes

Pilkis, S. J., & Claus, T. H. (1991) · Annual Review of Nutrition · doi:10.1146/annurev.nu.11.070191.002341 · Cited by 177 · see citing works

Responses of metabolic systems to large changes in enzyme activities and effectors

SMALL, J. R., & KACSER, H. (1993) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1993.tb17801.x · Cited by 164 · see citing works

A strategy for increasing an in vivo flux by genetic manipulations. The tryptophan system of yeast

Niederberger, P., Prasad, R., Miozzari, G., & KACSER, H. (1992) · Biochemical Journal · doi:10.1042/bj2870473 · Cited by 162 · see citing works

Control theory of regulatory cascades

Kahn, D., & Westerhoff, H. V. (1991) · Journal of Theoretical Biology · doi:10.1016/s0022-5193(05)80426-6 · Cited by 160 · see citing works

Quantitative assessment of regulation in metabolic systems

Hofmeyr, J. S., & Cornish-Bowden, A. J. (1991) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1991.tb21071.x · Cited by 146 · see citing works

Studies on the mechanism of repression of arginine biosynthesis in Escherichia coli

Maas, W. K., & Clark, A. J. (1964) · Journal of Molecular Biology · doi:10.1016/s0022-2836(64)80200-x · Cited by 121 · see citing works

Effects of overexpression of phosphofructokinase on glycolysis in the yeast Saccharomyces cerevisiae

Davies, S., & Brindle, K. M. (1992) · Biochemistry · doi:10.1021/bi00134a028 · Cited by 113 · see citing works

Energy metabolism of the cell

Oldham, J. D. (1982) · Endeavour · doi:10.1016/0160-9327(82)90053-9 · Cited by 112 · see citing works

Isolation and characterization of the two structural genes coding for phosphofructokinase in yeast

Heinisch, J. J. (1986) · Molecular and General Genetics MGG · doi:10.1007/bf00330520 · Cited by 110 · see citing works

Transcriptional control of genes that regulate glycolysis and gluconeogenesis in adult liver

Lemaigre, F. P., & Rousseau, G. G. (1994) · Biochemical Journal · doi:10.1042/bj3030001 · Cited by 108 · see citing works

Optimal design of feedback control by inhibition

Savageau, M. A. (1974) · Journal of Molecular Evolution · doi:10.1007/bf01732019 · Cited by 97 · see citing works

Regulation of Steroid Hydroxylase Gene Expression Is Multifactorial in Nature

Waterman, M. R., & Simpson, E. R. (1989) · Elsevier eBooks · doi:10.1016/b978-0-12-571145-6.50016-9 · Cited by 86 · see citing works

Responses of metabolic systems to large changes in enzyme activities and effectors

SMALL, J. R., & KACSER, H. (1993) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1993.tb17802.x · Cited by 85 · see citing works

Fine control of the glyoxylate cycle by allosteric inhibition of isocitrate lyase

Ashworth, J. M., & Kornberg, H. L. (1963) · Biochimica et Biophysica Acta (BBA) - Specialized Section on Enzymological Subjects · doi:10.1016/0926-6569(63)90145-7 · Cited by 85 · see citing works

ACTH and the Metabolism of Adrenal Cell Cultures

Kowal, J. (1970) · Elsevier eBooks · doi:10.1016/b978-0-12-571126-5.50020-0 · Cited by 76 · see citing works

Role of phosphate in the regulation of the Pasteur effect in Saccharomyces cerevisiae

Lagunas, R., & Gancedo, C. (1983) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1983.tb07851.x · Cited by 68 · see citing works

Regulation of stromal sedoheptulose 1,7-bisphosphatase activity by pH and Mg2+ concentration.

Woodrow, I. E., Murphy, D. J., & Latzko, E. (1984) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)43164-4 · Cited by 63 · see citing works

Complexities of metabolic regulation

Srere, P. A. (1994) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(94)90048-5 · Cited by 53 · see citing works

MUTANTS IN GLUCOSE METABOLISM

Fraenkel, D. G. (1986) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.55.070186.001533 · Cited by 50 · see citing works

Methyl-esterified proteins in a mammalian cell line

Chelsky, D., Ruskin, B., & Koshland, D. E. (1985) · Biochemistry · doi:10.1021/bi00344a053 · Cited by 48 · see citing works

Equilibria of two-partner reactions of energy supplying metabolism in muscle

Hohorst, H. J., Reim, M., & Bartels, H. (1962) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(62)90162-6 · Cited by 45 · see citing works

GENETICS AND INTERMEDIARY METABOLISM

Fraenkel, D. G. (1992) · Annual Review of Genetics · doi:10.1146/annurev.ge.26.120192.001111 · Cited by 43 · see citing works

17th Fritz Lipmann Lecture. Wanderings (wonderings) in metabolism.

Srere, P. A. (1993) · PubMed · Cited by 33 · see citing works

The effect of feedback on pathway transient response

Easterby, J. S. (1986) · Biochemical Journal · doi:10.1042/bj2330871 · Cited by 32 · see citing works

Genetic control of metabolism: enzyme studies of theobeseandadiposemutants in the mouse

Bulfield, G. (1972) · Genetics Research · doi:10.1017/s0016672300013586 · Cited by 30 · see citing works

Fine control of the glyoxylate cycle by allosteric inhibition of isocitrate lyase

Ashworth, J. M., & Kornberg, H. L. (1963) · Biochimica et Biophysica Acta · doi:10.1016/0006-3002(63)90457-8 · Cited by 9 · see citing works

Transition time control analysis of a glycolytic system under different glucose concentrations. Control of transition time versus control of flux

Torres, N., & Mel�ndez-Hevia, E. (1992) · Molecular and Cellular Biochemistry · doi:10.1007/bf00227567 · Cited by 6 · see citing works

Cellular energy utilization and molecular origin of standard metabolic rate in mammals

Rolfe, D. F., & Brown, G. C. (1997) · Physiological Reviews · doi:10.1152/physrev.1997.77.3.731 · Cited by 2,021 · see citing works

Short-Chain Fatty Acids Protect Against High-Fat Diet–Induced Obesity via a PPARγ-Dependent Switch From Lipogenesis to Fat Oxidation

den Besten, G., Bleeker, A., Gerding, A., van Eunen, K., Havinga, R., van Dijk, T. H., Oosterveer, M. H., Jonker, J. W., Groen, A. K., Reijngoud, D.-J., et al. (2015) · Diabetes · doi:10.2337/db14-1213 · Cited by 1,125 · see citing works

Glycolytic Enzymes Can Modulate Cellular Life Span

Kondoh, H., Lleonart, M. E., Gil, J., Wang, J., Degan, P., Peters, G., Martinez, D., Carnero, A., & Beach, D. (2005) · Cancer Research · doi:10.1158/0008-5472.177.65.1 · Cited by 647 · see citing works

Control of mitochondrial β-oxidation flux

Eaton, S. D. (2002) · Progress in Lipid Research · doi:10.1016/s0163-7827(01)00024-8 · Cited by 410 · see citing works

Arabidopsis and primary photosynthetic metabolism – more than the icing on the cake

Stitt, M., Lunn, J. E., & Usadel, B. (2010) · The Plant Journal · doi:10.1111/j.1365-313x.2010.04142.x · Cited by 348 · see citing works

How can we make plants grow faster? A source–sink perspective on growth rate

White, A. C., Rogers, A., Rees, M., & Osborne, C. P. (2015) · Journal of Experimental Botany · doi:10.1093/jxb/erv447 · Cited by 335 · see citing works

A Small Decrease of Plastid Transketolase Activity in Antisense Tobacco Transformants Has Dramatic Effects on Photosynthesis and Phenylpropanoid Metabolism

Henkes, S., Sonnewald, U., Badur, R., Flachmann, R., & Stitt, M. (2001) · The Plant Cell · doi:10.1105/tpc.13.3.535 · Cited by 334 · see citing works

Membranes as Possible Pacemakers of Metabolism

Hulbert, A. J., & Else, P. L. (1999) · Journal of Theoretical Biology · doi:10.1006/jtbi.1999.0955 · Cited by 312 · see citing works

Effect of Calcium on the Oxidative Phosphorylation Cascade in Skeletal Muscle Mitochondria

Glancy, B. C., Willis, W. T., Chess, D. J., & Balaban, R. S. (2013) · Biochemistry · doi:10.1021/bi3015983 · Cited by 299 · see citing works

Flux control of sulphate assimilation in Arabidopsis thaliana : adenosine 5′‐phosphosulphate reductase is more susceptible than ATP sulphurylase to negative control by thiols

Vauclare, P., Kopřiva, S., Fell, D. A., Suter, M., Sticher, L., von Ballmoos, P., Krähenbühl, U., den Camp, R. O., & Brunold, C. (2002) · The Plant Journal · doi:10.1046/j.1365-313x.2002.01391.x · Cited by 282 · see citing works

The fluxes through glycolytic enzymes in Saccharomyces cerevisiae are predominantly regulated at posttranscriptional levels

Daran-Lapujade, P. A. S., Rossell, S., van Gulik, W. M., Luttik, M. A. H., de Groot, M. J. L., Slijper, M., Heck, A. J. R., Daran, J.-M. G., de Winde, J. H., Westerhoff, H. V., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707476104 · Cited by 248 · see citing works

Does autophagy have a license to kill mammalian cells?

Scarlatti, F., Granata, R., Meijer, A. J., & Codogno, P. (2008) · Cell Death and Differentiation · doi:10.1038/cdd.2008.101 · Cited by 240 · see citing works

Analysis of Selection on Enzyme Polymorphisms

Eanes, W. F. (1999) · Annual Review of Ecology and Systematics · doi:10.1146/annurev.ecolsys.30.1.301 · Cited by 223 · see citing works

UDP-glucose accelerates SNAI1 mRNA decay and impairs lung cancer metastasis

Wang, X., Liu, R., Zhu, W., Chu, H., Yu, H. T., Wei, P., Wu, X., Zhu, H., Gao, H., Liang, J., et al. (2019) · Nature · doi:10.1038/s41586-019-1340-y · Cited by 215 · see citing works

Metabolic Networks: How to Identify Key Components in the Regulation of Metabolism and Growth

Stitt, M., Ronan Sulpice, A., & Keurentjes, J. J. B. (2009) · PLANT PHYSIOLOGY · doi:10.1104/pp.109.150821 · Cited by 201 · see citing works

Computing the shortest elementary flux modes in genome-scale metabolic networks

de Figueiredo, L. F., Podhorski, A., Rubio, Á., Kaleta, C., Beasley, J. E., Schuster, S., & Planes, F. J. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp564 · Cited by 198 · see citing works

Transcriptional regulation is insufficient to explain substrate-induced flux changes in Bacillus subtilis

Chubukov, V., Uhr, M., Le Chat, L., Kleijn, R. J., Jules, M., Link, H., Aymerich, S., Stelling, J., & Sauer, U. (2013) · Molecular Systems Biology · doi:10.1038/msb.2013.66 · Cited by 191 · see citing works

Application of the “-Omic-” technologies in phytomedicine

Ulrich-Merzenich, G. S., Zeitler, H.-J., Jobst, D., Panek, D., Vetter, H., & Wagner, H. (2006) · Phytomedicine · doi:10.1016/j.phymed.2006.11.011 · Cited by 184 · see citing works

Sulfite Reductase Defines a Newly Discovered Bottleneck for Assimilatory Sulfate Reduction and Is Essential for Growth and Development in <i>Arabidopsis thaliana</i>

Khan, M. S., Haas, F. H., Allboje Samami, A., Moghaddas Gholami, A., Bauer, A., Fellenberg, K., Reichelt, M., HÄnsch, R., Mendel, R. R., Meyer, A. J., et al. (2010) · The Plant Cell · doi:10.1105/tpc.110.074088 · Cited by 182 · see citing works

Dynamic simulation and metabolic re-design of a branched pathway using linlog kinetics

Visser, D., & Heijnen, J. J. (2003) · Metabolic Engineering · doi:10.1016/s1096-7176(03)00025-9 · Cited by 167 · see citing works

How aneuploidy affects metabolic control and causes cancer

Rasnick, D., & DUESBERG, P. H. (1999) · Biochemical Journal · doi:10.1042/bj3400621 · Cited by 164 · see citing works

Energy Metabolism during Insect Flight: Biochemical Design and Physiological Performance

Suarez, R. K. (2000) · Physiological and Biochemical Zoology · doi:10.1086/318112 · Cited by 160 · see citing works

Regulation of ATP supply during muscle contraction: theoretical studies

Korzeniewski, B. (1998) · Biochemical Journal · doi:10.1042/bj3301189 · Cited by 153 · see citing works

Network Analysis of Enzyme Activities and Metabolite Levels and Their Relationship to Biomass in a Large Panel ofArabidopsisAccessions

Ronan Sulpice, A., Trenkamp, S., Steinfath, M., Usadel, B., Gibon, Y., Witucka‐Wall, H., Pyl, E., Tschoep, H., Steinhauser, M. C., Guenther, M., et al. (2010) · The Plant Cell · doi:10.1105/tpc.110.076653 · Cited by 151 · see citing works

Simultaneous genomic overexpression of seven glycolytic enzymes in the yeast Saccharomyces cerevisiae

Hauf, J., Zimmermann, F. K., & Müller, S. (2000) · Enzyme and Microbial Technology · doi:10.1016/s0141-0229(00)00160-5 · Cited by 151 · see citing works

Metabolic management of brain cancer

Seyfried, T. N., Kiebish, M. A., Marsh, J., Shelton, L. M., Huysentruyt, L. C., & Mukherjee, P. (2010) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2010.08.009 · Cited by 146 · see citing works

Metabolomics, modelling and machine learning in systems biology – towards an understanding of the languages of cells

Kell, D. B. (2006) · FEBS Journal · doi:10.1111/j.1742-4658.2006.05136.x · Cited by 147 · see citing works

Multiple mechanisms controlling carbon metabolism in bacteria

Saier, M. H. (1998) · Biotechnology and Bioengineering · doi:10.1002/(sici)1097-0290(19980420)58:2/3 · Cited by 97 · see citing works

Unraveling the complexity of flux regulation: A new method demonstrated for nutrient starvation in Saccharomyces cerevisiae

Rossell, S., van der Weijden, C. C., Lindenbergh, A., van Tuijl, A., Francke, C., Bakker, B. M., & Westerhoff, H. V. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509831103 · Cited by 134 · see citing works

Regulation Analysis Of Energy Metabolism

Brand, M. D. (1997) · Journal of Experimental Biology · doi:10.1242/jeb.200.2.193 · Cited by 132 · see citing works

Allometric cascade: a model for resolving body mass effects on metabolism

Hochachka, P. W., Darveau, C.-A., Andrews, R. D., & Suarez, R. K. (2003) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/s1095-6433(02)00364-1 · Cited by 125 · see citing works

Role of Hexose Transport in Control of Glycolytic Flux in Saccharomyces cerevisiae

Elbing, K., Larsson, C., Bill, R. M., Albers, E., Snoep, J. L., Boles, E., Hohmann, S., & Gustafsson, L. (2004) · Applied and Environmental Microbiology · doi:10.1128/aem.70.9.5323-5330.2004 · Cited by 123 · see citing works

Optimal re-design of primary metabolism in Escherichia coli using linlog kinetics

Visser, D., Schmid, J. W., Mauch, K., Reuß, M., & Heijnen, J. J. (2004) · Metabolic Engineering · doi:10.1016/j.ymben.2004.07.001 · Cited by 112 · see citing works

No effects without causes: the Iron Dysregulation and Dormant Microbes hypothesis for chronic, inflammatory diseases

Kell, D. B., & Pretorius, E. (2018) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12407 · Cited by 113 · see citing works

13C NMR of Intermediary Metabolism: Implications for Systemic Physiology

Shulman, R. G., & Rothman, D. L. (2001) · Annual Review of Physiology · doi:10.1146/annurev.physiol.63.1.15 · Cited by 108 · see citing works

Changes in Photosynthetic Rates and Gene Expression of Leaves during a Source–Sink Perturbation in Sugarcane

McCormick, A. J., Cramer, M. D., & Watt, D. A. (2007) · Annals of Botany · doi:10.1093/aob/mcm258 · Cited by 107 · see citing works

The non-oxidative pentose phosphate pathway controls the fermentation rate of xylulose but not of xylose inSaccharomyces cerevisiaeTMB3001

Johansson, B., & Hähn‐Hägerdal, B. (2002) · FEMS Yeast Research · doi:10.1111/j.1567-1364.2002.tb00095.x · Cited by 105 · see citing works

Interrelations of ATP synthesis and proton handling in ischaemically exercising human forearm muscle studied by 31P magnetic resonance spectroscopy

Kemp, G. J., Roussel, M., Bendahan, D., Fur, Y. L., & Cozzone, P. J. (2001) · The Journal of Physiology · doi:10.1111/j.1469-7793.2001.00901.x · Cited by 102 · see citing works

Do mammals, birds, reptiles and fish have similar nitrogen conserving systems?

Singer, M. A. (2003) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/s1096-4959(03)00027-7 · Cited by 102 · see citing works

Control of glycolysis in contracting skeletal muscle. II. Turning it off

Crowther, G. J., Kemper, W. F., Carey, M. F., & Conley, K. E. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2002.282.1.e74 · Cited by 101 · see citing works

Gene targeting: technical confounds and potential solutions in behavioral brain research

Gerlai, R. T. (2001) · Behavioural Brain Research · doi:10.1016/s0166-4328(01)00282-0 · Cited by 101 · see citing works

Regulation of oxidative phosphorylation through parallel activation

Korzeniewski, B. (2007) · Biophysical Chemistry · doi:10.1016/j.bpc.2007.05.013 · Cited by 92 · see citing works

The modelling of metabolic systems. Structure, control and optimality

Heinrich, R., & Schuster, S. (1998) · Biosystems · doi:10.1016/s0303-2647(98)00013-6 · Cited by 92 · see citing works

Shuffling of Promoters for Multiple Genes To Optimize Xylose Fermentation in an Engineered Saccharomyces cerevisiae Strain

Lu, C., & Jeffries, T. W. (2007) · Applied and Environmental Microbiology · doi:10.1128/aem.00955-07 · Cited by 89 · see citing works

Energy metabolism design of the striated muscle cell

Glancy, B. C., & Balaban, R. S. (2021) · Physiological Reviews · doi:10.1152/physrev.00040.2020 · Cited by 83 · see citing works

Steps towards a mechanistic understanding of respiratory temperature responses

Kruse, J., Rennenberg, H., & Adams, M. A. (2011) · New Phytologist · doi:10.1111/j.1469-8137.2010.03576.x · Cited by 81 · see citing works

Calcium regulation of oxidative phosphorylation in rat skeletal muscle mitochondria

Kavanagh, N. I., Ainscow, E., & Brand, M. D. (2000) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(00)00054-2 · Cited by 80 · see citing works

Metabolic Control Analysis of glycolysis in tuber tissue of potato (Solanum tuberosum): explanation for the low control coefficient of phosphofructokinase over respiratory flux

THOMAS, S., MOONEY, P. J. F., Burrell, M. M., & Fell, D. A. (1997) · Biochemical Journal · doi:10.1042/bj3220119 · Cited by 80 · see citing works

Oxygen and the Upper Limits to Animal Design and Performance

Suarez, R. K. (1998) · Journal of Experimental Biology · doi:10.1242/jeb.201.8.1065 · Cited by 78 · see citing works

The urea cycle: Teaching intermediary metabolism in a physiological setting

Watford, M. (2003) · Biochemistry and Molecular Biology Education · doi:10.1002/bmb.2003.494031050249 · Cited by 76 · see citing works

Control of glycolysis in contracting skeletal muscle. I. Turning it on

Crowther, G. J., Carey, M. F., Kemper, W. F., & Conley, K. E. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2002.282.1.e67 · Cited by 71 · see citing works

A control analysis exploration of the role of ATP utilisation in glycolytic‐flux control and glycolytic‐metabolite‐concentration regulation

Thomas, S., & Fell, D. A. (1998) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.1998.2580956.x · Cited by 70 · see citing works

Control of the threonine-synthesis pathway in Escherichia coli: a theoretical and experimental approach

Chassagnole, C., Fell, D. A., RAÏS, B., Kudla, B., & Mazat, J. (2001) · Biochemical Journal · doi:10.1042/0264-6021:3560433 · Cited by 69 · see citing works

Hexokinase II Overexpression Improves Exercise-Stimulated But Not Insulin-Stimulated Muscle Glucose Uptake in High-Fat-Fed C57BL/6J Mice

Fueger, P. T., Bracy, D. P., Malabanan, C. M., Pencek, R., Granner, D. K., & Wasserman, D. H. (2004) · Diabetes · doi:10.2337/diabetes.53.2.306 · Cited by 69 · see citing works

Control of muscle glucose uptake: test of the rate‐limiting step paradigm in conscious, unrestrained mice

Fueger, P. T., Shearer, J., Bracy, D. P., Posey, K. A., Pencek, R., McGuinness, O. P., & Wasserman, D. H. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.076158 · Cited by 68 · see citing works

Metabolic control analysis of the Warburg-effect in proliferating vascular smooth muscle cells

Werle, M., Kreuzer, J., Hoefele, J., Elsässer, A., Ackermann, C., Katus, H. A., & Vogt, A. M. (2005) · Journal of Biomedical Science · doi:10.1007/s11373-005-9010-5 · Cited by 68 · see citing works

The role of multiple enzyme activation in metabolic flux control

Thomas, S., & Fell, D. A. (1998) · Advances in Enzyme Regulation · doi:10.1016/s0065-2571(97)00012-5 · Cited by 68 · see citing works

Efficient discovery of anti-inflammatory small-molecule combinations using evolutionary computing

Small, B. G., McColl, B. W., Allmendinger, R., Pahle, J., López‐Castejón, G., Rothwell, N. J., Knowles, J. D., Mendes, P., Brough, D., & Kell, D. B. (2011) · Nature Chemical Biology · doi:10.1038/nchembio.689 · Cited by 67 · see citing works

Mathematical modelling of metabolism

Giersch, C. (2000) · Current Opinion in Plant Biology · doi:10.1016/s1369-5266(00)80073-4 · Cited by 67 · see citing works

Nature's inordinate fondness for metabolic enzymes: why metabolic enzyme loci are so frequently targets of selection

Marden, J. H. (2013) · Molecular Ecology · doi:10.1111/mec.12534 · Cited by 65 · see citing works

Glyceraldehyde-3-Phosphate Dehydrogenase Has No Control over Glycolytic Flux in Lactococcus lactis MG1363

Solem, C., Koebmann, B. J., & Jensen, P. R. (2003) · Journal of Bacteriology · doi:10.1128/jb.185.5.1564-1571.2003 · Cited by 66 · see citing works

Expression of Genes Encoding F 1 -ATPase Results in Uncoupling of Glycolysis from Biomass Production in Lactococcus lactis

Koebmann, B. J., Solem, C., Pedersen, M. B., Nilsson, D., & Jensen, P. R. (2002) · Applied and Environmental Microbiology · doi:10.1128/aem.68.9.4274-4282.2002 · Cited by 66 · see citing works

Regulation of ATP supply in mammalian skeletal muscle during resting state→intensive work transition

Korzeniewski, B. (2000) · Biophysical Chemistry · doi:10.1016/s0301-4622(99)00120-9 · Cited by 66 · see citing works

Synergistic control of oscillations in the NF-B signalling pathway

Ihekwaba, A., Broomhead, D. S., Grimley, R. L., Benson, N., White, M., & Kell, D. B. (2005) · Systems Biology · doi:10.1049/ip-syb:20050050 · Cited by 54 · see citing works

Metabolic analysis reveals changes in the mevalonate and juvenile hormone synthesis pathways linked to the mosquito reproductive physiology

Rivera-Pérez, C., Nouzová, M., Lamboglia, I., & Noriega, F. G. (2014) · Insect Biochemistry and Molecular Biology · doi:10.1016/j.ibmb.2014.05.001 · Cited by 52 · see citing works

Control limits for accumulation of plant metabolites: brute force is no substitute for understanding

Morandini, P. A. (2013) · Plant Biotechnology Journal · doi:10.1111/pbi.12035 · Cited by 52 · see citing works

Regulation of oxidative phosphorylation in intact mammalian heart in vivo

Korzeniewski, B., Noma, A., & Matsuoka, S. (2005) · Biophysical Chemistry · doi:10.1016/j.bpc.2005.04.001 · Cited by 51 · see citing works

Mutant studies of phosphofructo-2-kinases do not reveal an essential role of fructose-2, 6-bisphosphate in the regulation of carbon fluxes in yeast cells

Müller, S., Zimmermann, F. K., & Boles, E. (1997) · Microbiology · doi:10.1099/00221287-143-9-3055 · Cited by 51 · see citing works

Mechanisms responsible for the acceleration of pulmonary V o 2on-kinetics in humans after prolonged endurance training

Zoladz, J. A., Grassi, B., Majerczak, J., Szkutnik, Z., Korostyński, M., Grandys, M., Jarmuszkiewicz, W., & Korzeniewski, B. (2014) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00046.2014 · Cited by 50 · see citing works

Tuning transcription of nutrient utilization genes to catabolic rate promotes growth in a gut bacterium

Raghavan, V., Lowe, E. C., Townsend, G. E., Bolam, D. N., & Groisman, E. A. (2014) · Molecular Microbiology · doi:10.1111/mmi.12714 · Cited by 50 · see citing works

Metabolomic biomarkers: search, discovery and validation

Kell, D. B. (2007) · Expert Review of Molecular Diagnostics · doi:10.1586/14737159.7.4.329 · Cited by 50 · see citing works

Sirtuins-Mediated System-Level Regulation of Mammalian Tissues at the Interface between Metabolism and Cell Cycle: A Systematic Review

Maissan, P., Mooij, E., & Barberis, M. (2021) · Biology · doi:10.3390/biology10030194 · Cited by 50 · see citing works

17 Metabolic Control Analysis as a Tool in the Elucidation of the Function of Novel Genes

Teusink, B., Baganz, F., Westerhoff, H. V., & Oliver, S. G. (1998) · Methods in microbiology · doi:10.1016/s0580-9517(08)70338-6 · Cited by 49 · see citing works

A Minimal Set of Glycolytic Genes Reveals Strong Redundancies in Saccharomyces cerevisiae Central Metabolism

Solis-Escalante, D., Kuijpers, N. G. A., Barrajón, N., van den Broek, M. A., Pronk, J. T., Daran, J.-M. G., & Daran-Lapujade, P. A. S. (2015) · Eukaryotic Cell · doi:10.1128/ec.00064-15 · Cited by 46 · see citing works

Genome-scale metabolic modeling underscores the potential of Cutaneotrichosporon oleaginosus ATCC 20509 as a cell factory for biofuel production

Pham, N., Reijnders, M. J. M. F., Diez, M. S., Nijsse, B., Springer, J., Eggink, G., & Schaap, P. J. (2021) · Biotechnology for Biofuels · doi:10.1186/s13068-020-01838-1 · Cited by 48 · see citing works

Finite change analysis of glycolytic intermediates in tuber tissue of lines of transgenic potato (Solanum tuberosum) overexpressing phosphofructokinase

THOMAS, S., MOONEY, P. J. F., Burrell, M. M., & Fell, D. A. (1997) · Biochemical Journal · doi:10.1042/bj3220111 · Cited by 45 · see citing works

Effects of Cadmium and Mercury on the Upper Part of Skeletal Muscle Glycolysis in Mice

Ramírez-Bajo, M. J., de Atauri, P., Ortega, F. G., Westerhoff, H. V., Gelpí, J. L., Centelles, J. J., & Cascante, M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0080018 · Cited by 44 · see citing works

Enzymatic phosphorylation of muscle glycogen synthase: a mechanism for maintenance of metabolic homeostasis.

Shulman, R. G., & Rothman, D. L. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.15.7491 · Cited by 44 · see citing works

Model-based metabolism design: constraints for kinetic and stoichiometric models

Stalidzāns, E., Seiman, A., Peebo, K., Komašilovs, V., & Pentjuss, A. (2018) · Biochemical Society Transactions · doi:10.1042/bst20170263 · Cited by 43 · see citing works

Regulation of Glycolytic Flux in Ischemic Preconditioning

Vogt, A. M., Poolman, M. G., Ackermann, C., Yıldız, M., Schoels, W., Fell, D. A., & Kübler, W. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201138200 · Cited by 41 · see citing works

Microevolution of intermediary metabolism: evolutionary genetics meets metabolic biochemistry

Zera, A. J. (2010) · Journal of Experimental Biology · doi:10.1242/jeb.046912 · Cited by 40 · see citing works

Transcription of hexose transporters of Saccharomyces cerevisiae is affected by change in oxygen provision

Rintala, E., Wiebe, M. G., Tamminen, A., Ruohonen, L., & Penttilä, M. E. (2008) · BMC Microbiology · doi:10.1186/1471-2180-8-53 · Cited by 40 · see citing works

Flight muscle enzymes and metabolic flux rates during hovering flight of the nectar bat, Glossophaga soricina: Further evidence of convergence with hummingbirds

Suarez, R. K., Welch, K. C., Hanna, S. K., & M., L. G. H. (2009) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/j.cbpa.2009.01.015 · Cited by 37 · see citing works

Metabolic control analysis: biological applications and insights.

Wildermuth, M. C. (2000) · Genome biology · doi:10.1186/gb-2000-1-6-reviews1031 · Cited by 37 · see citing works

Genome-Wide Association Mapping Reveals That Specific and Pleiotropic Regulatory Mechanisms Fine-Tune Central Metabolism and Growth in Arabidopsis

Fusari, C. M., Kooke, R., Lauxmann, M. A., Annunziata, M. G., Encke, B., Höhne, M., Krohn, N., Becker, F. F. M., Schlereth, A., Ronan Sulpice, A., et al. (2017) · The Plant Cell · doi:10.1105/tpc.17.00232 · Cited by 33 · see citing works

Running‐wheel activity delays mitochondrial respiratory flux decline in aging mouse muscle via a post‐transcriptional mechanism

Stolle, S., Čiapaitė, J., Reijne, A. C., Talarovičová, A., Wolters, J. C., Aguirre‐Gamboa, R., van der Vlies, P., de Lange, K., Neerincx, P. B. T., van der Vries, G. B., et al. (2017) · Aging Cell · doi:10.1111/acel.12700 · Cited by 36 · see citing works

Use and Limitations of Modular Metabolic Control Analysis in Medicine and Biotechnology

Schuster, S. (1999) · Metabolic Engineering · doi:10.1006/mben.1999.0119 · Cited by 36 · see citing works

Snapshots of Systems

Kell, D. B., & Mendes, P. (2000) · Springer eBooks · doi:10.1007/978-94-011-4072-0_1 · Cited by 36 · see citing works

Metabolic control over the oxygen consumption flux in intact skeletal muscle: in silico studies

Liguzinski, P., & Korzeniewski, B. (2006) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00078.2006 · Cited by 35 · see citing works

Evolution of design principles in biochemical networks

de Atauri, P., Bolouri, H., Ramsey, S. A., & Orrell, D. (2004) · Systems Biology · doi:10.1049/sb:20045013 · Cited by 34 · see citing works

Human aerobic performance: too much ado about limits to VO2

Lindstedt, S. L., & Conley, K. E. (2001) · Journal of Experimental Biology · doi:10.1242/jeb.204.18.3195 · Cited by 33 · see citing works

Oxygen availability regulates metabolism and gene expression in trout hepatocyte cultures

Rissanen, E., Tranberg, H. K., & Nikinmaa, M. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00025.2006 · Cited by 32 · see citing works

Integrating metabolic pathway fluxes with gene-to-enzyme expression rates

Hochachka, P. W., McClelland, G. B., Burness, G., Staples, J. F., & Suarez, R. K. (1998) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/s0305-0491(98)00019-4 · Cited by 32 · see citing works

Impact of kinetic isotope effects in isotopic studies of metabolic systems

Millard, P., Portais, J., & Mendes, P. (2015) · BMC Systems Biology · doi:10.1186/s12918-015-0213-8 · Cited by 31 · see citing works

Regulation of oxidative phosphorylation through each-step activation (ESA): Evidences from computer modeling

Korzeniewski, B. (2016) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2016.12.001 · Cited by 31 · see citing works

UDP-glucuronate metabolism controls RIPK1-driven liver damage in nonalcoholic steatohepatitis

Zhang, T., Zhang, N., Xing, J., Zhang, S., Chen, Y., Xu, D., & Gu, J. (2023) · Nature Communications · doi:10.1038/s41467-023-38371-2 · Cited by 30 · see citing works

(Im)Perfect robustness and adaptation of metabolic networks subject to metabolic and gene-expression regulation: marrying control engineering with metabolic control analysis

He, F., Fromion, V., & Westerhoff, H. V. (2013) · BMC Systems Biology · doi:10.1186/1752-0509-7-131 · Cited by 31 · see citing works

The responses of rat hepatocytes to glucagon and adrenaline

Ainscow, E., & Brand, M. D. (1999) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.1999.00820.x · Cited by 31 · see citing works

Increasing oil content in Brassica oilseed species

Weselake, R. J., Fell, D. A., Wang, X., Scofield, S., Chen, G., & Harwood, J. L. (2024) · Progress in Lipid Research · doi:10.1016/j.plipres.2024.101306 · Cited by 29 · see citing works

Protein phosphorylation can regulate metabolite concentrations rather than control flux: The example of glycogen synthase

Schafer, J. R. A., Fell, D. A., Rothman, D. L., & Shulman, R. G. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307299101 · Cited by 28 · see citing works

The role of multiple enzyme activation in metabolic flux control

Thomas, S., & Fell, D. A. (1998) · Advances in Enzyme Regulation · doi:10.1016/s0065-2571(97)00012-5 · Cited by 68 · see citing works

Design of Metabolic Control for Large Flux Changes

Thomas, S., & Fell, D. A. (1996) · Journal of Theoretical Biology · doi:10.1006/jtbi.1996.0166 · Cited by 44 · see citing works

Enzyme Catalysed Fluxes in Metabolic Systems. Why Control of Such Fluxes is Shared Among All Components of the System

Porteous, J. W. (1985) · Proceedings in life sciences · doi:10.1007/978-3-642-70610-3_20 · Cited by 5 · see citing works

Strategies for Manipulating Metabolic Fluxes in Biotechnology

Cornish-Bowden, A. J., Hofmeyr, J. H., & Cárdenas, M. L. (1995) · Bioorganic Chemistry · doi:10.1006/bioo.1995.1030 · Cited by 86 · see citing works

Rethinking metabolic control

Morandini, P. A. (2009) · Plant Science · doi:10.1016/j.plantsci.2009.01.005 · Cited by 55 · see citing works