The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Physiological control of metabolic flux: the requirement for multisite modulation
Open accessAbstract
Biochemists have long assumed that the flux through a metabolic pathway can be controlled by the activity of a key regulatory enzyme near the beginning of the pathway. We present the accumulating evidence that every step in this assumption is flawed. Instead, effective physiological control of metabolism is shown to involve simultaneous multisite modulation through action on a number of enzymes.
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“Although it has been suggested that the activity of complex metabolic pathways cannot be modulated by the abundance of a single component enzyme (49), our studies reveal the unexpected ease with which the glycolytic flux of mammalian cells can be genetically manipulated, at least in MEFs.”
From Glycolytic Enzymes Can Modulate Cellular Life Span (2005) · cites this paper as [49]
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Metadata
- Authors
- Fell, D. A., & Thomas, S.
- Affiliations
- Oxford Brookes University (GB)
- ORCID
- Fell, D A
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 1995-10-01
- Volume
- 311
- Issue
- 1
- Pages
- 35-39
- ISSN
- 0264-6021 (ISSN-L)
- 1470-8728
- PMC
- PMC1136115
- OpenAlex
- W1864895841
- Cited by
- 218
- References
- 38
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 2 · 2023: 9 · 2022: 4 · 2021: 7 · 2020: 1 · 2019: 3 · 2018: 6 · 2017: 7 · 2016: 4 · 2015: 5 · 2014: 7 · 2013: 9 · 2012: 5
- FWCI
- 0.69
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Biochemical Journal (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Leverhulme Trust
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
- Keywords
- metabolic flux control, enzyme regulation, metabolic pathways, enzyme activity modulation
- MeSH terms
- Binding Sites, Enzyme Activation, Enzymes, Feedback, Homeostasis, Metabolism, Models, Biological
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