The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Physiological control of metabolic flux: the requirement for multisite modulation
Open accessAbstract
Biochemists have long assumed that the flux through a metabolic pathway can be controlled by the activity of a key regulatory enzyme near the beginning of the pathway. We present the accumulating evidence that every step in this assumption is flawed. Instead, effective physiological control of metabolism is shown to involve simultaneous multisite modulation through action on a number of enzymes.
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“Although it has been suggested that the activity of complex metabolic pathways cannot be modulated by the abundance of a single component enzyme (49), our studies reveal the unexpected ease with which the glycolytic flux of mammalian cells can be genetically manipulated, at least in MEFs.”
From Glycolytic Enzymes Can Modulate Cellular Life Span (2005) · cites this paper as [49]
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Cites
Positional cloning of the mouse obese gene and its human homologue
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Metabolic control analysis: a survey of its theoretical and experimental development
Fell, D. A. (1992) · Biochemical Journal · doi:10.1042/bj2860313 · Cited by 782
Self-citationAmino Acid Biosynthesis and its Regulation
Umbarger, H. E. (1978) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.47.070178.002533 · Cited by 744
Adaptive Characteristics of Urea Cycle Enzymes in the Rat
SCHIMKE, R. T. (1962) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)93943-8 · Cited by 735
Physiological and molecular mechanisms involved in nutritional regulation of fatty acid synthesis
Hillgartner, F. B., Salati, L. M., & Goodridge, A. G. (1995) · Physiological Reviews · doi:10.1152/physrev.1995.75.1.47 · Cited by 459
Overproduction of glycolytic enzymes in yeast
Schaaff‐Gerstenschläger, I., Heinisch, J. J., & Zimmermann, F. K. (1989) · Yeast · doi:10.1002/yea.320050408 · Cited by 297
Regulation of Metabolism in Working Muscle in Vivo
Sacktor, B., & Wormser-Shavit, E. (1966) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)96883-3 · Cited by 217
Weber, G., Singhal, R. L., Stamm, N. B., Lea, M. A., & Fisher, E. A. (1966) · Advances in Enzyme Regulation · doi:10.1016/0065-2571(66)90007-0 · Cited by 193
Research works printed but not linked: 1
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Cellular energy utilization and molecular origin of standard metabolic rate in mammals
Rolfe, D. F., & Brown, G. C. (1997) · Physiological Reviews · doi:10.1152/physrev.1997.77.3.731 · Cited by 2,021
den Besten, G., Bleeker, A., Gerding, A., van Eunen, K., Havinga, R., van Dijk, T. H., Oosterveer, M. H., Jonker, J. W., Groen, A. K., Reijngoud, D.-J., et al. (2015) · Diabetes · doi:10.2337/db14-1213 · Cited by 1,125
Glycolytic Enzymes Can Modulate Cellular Life Span
Kondoh, H., Lleonart, M. E., Gil, J., Wang, J., Degan, P., Peters, G., Martinez, D., Carnero, A., & Beach, D. (2005) · Cancer Research · doi:10.1158/0008-5472.177.65.1 · Cited by 647
Control of mitochondrial β-oxidation flux
Eaton, S. D. (2002) · Progress in Lipid Research · doi:10.1016/s0163-7827(01)00024-8 · Cited by 420
Arabidopsis and primary photosynthetic metabolism – more than the icing on the cake
Stitt, M., Lunn, J. E., & Usadel, B. (2010) · The Plant Journal · doi:10.1111/j.1365-313x.2010.04142.x · Cited by 357
Metadata
- Authors
- Fell, D. A., & Thomas, S.
- Affiliations
- Oxford Brookes University (GB)
- ORCID
- Fell, D A
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 1995-10-01
- Volume
- 311
- Issue
- 1
- Pages
- 35-39
- ISSN
- 0264-6021 (ISSN-L)
- 1470-8728
- PMC
- PMC1136115
- OpenAlex
- W1864895841
- Cited by
- 218
- References
- 38
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 2 · 2023: 9 · 2022: 4 · 2021: 7 · 2020: 1 · 2019: 3 · 2018: 6 · 2017: 7 · 2016: 4 · 2015: 5 · 2014: 7 · 2013: 9 · 2012: 5
- FWCI
- 0.69
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Biochemical Journal (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Leverhulme Trust
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
- Keywords
- metabolic flux control, enzyme regulation, metabolic pathways, enzyme activity modulation
- MeSH terms
- Binding Sites, Enzyme Activation, Enzymes, Feedback, Homeostasis, Metabolism, Models, Biological
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