Cited by 218Biochemical and Molecular ResearchMicrobial Metabolic Engineering and BioproductionGene Regulatory Network Analysis

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Physiological control of metabolic flux: the requirement for multisite modulation

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Fell, D A, Thomas, S·1995·Biochemical Journal

DOI 10.1042/bj3110035PMC PMC1136115

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Abstract

Biochemists have long assumed that the flux through a metabolic pathway can be controlled by the activity of a key regulatory enzyme near the beginning of the pathway. We present the accumulating evidence that every step in this assumption is flawed. Instead, effective physiological control of metabolism is shown to involve simultaneous multisite modulation through action on a number of enzymes.

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Self-citation
Protein phosphorylation can regulate metabolite concentrations rather than control flux: The example of glycogen synthase
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Self-citation

Authors: Fell, D. A., & Thomas, S.
Affiliations: Oxford Brookes University (GB)
ORCID: Fell, D A
Venue: Biochemical Journal
Publisher: Portland Press Ltd.
Published: 1995-10-01
Volume: 311
Issue: 1
Pages: 35-39
ISSN: 0264-6021 (ISSN-L)
1470-8728
DOI: 10.1042/bj3110035
PMC: PMC1136115
OpenAlex: W1864895841
Cited by: 218
References: 38
Citations by year: 2026: 3 · 2025: 1 · 2024: 2 · 2023: 9 · 2022: 4 · 2021: 7 · 2020: 1 · 2019: 3 · 2018: 6 · 2017: 7 · 2016: 4 · 2015: 5 · 2014: 7 · 2013: 9 · 2012: 5
FWCI: 0.69
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Biochemical Journal (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Leverhulme Trust
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
Keywords: metabolic flux control, enzyme regulation, metabolic pathways, enzyme activity modulation
MeSH terms: Binding Sites, Enzyme Activation, Enzymes, Feedback, Homeostasis, Metabolism, Models, Biological

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Physiological control of metabolic flux: the requirement for multisite modulation

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