Cited by 373Plant biochemistry and biosynthesisLipid metabolism and biosynthesisPhotosynthetic Processes and Mechanisms

The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.

Biosynthesis of isoprenoids (carotenoids, sterols, prenyl side-chains of chlorophylls and plastoquinone) via a novel pyruvate/glyceraldehyde 3-phosphate non-mevalonate pathway in the green alga Scenedesmus obliquus

Open access

SCHWENDER, Jörg, SEEMANN, Myriam, LICHTENTHALER, Hartmut K., ROHMER, Michel·1996·Biochemical Journal

Open this paper in CoChat — free account Open PDF

Abstract

Isoprenoid biosynthesis was investigated in the green alga Scenedesmus obliquus grown heterotrophically on 13C-labelled glucose and acetate. Several isoprenoid compounds were isolated and investigated by 13C-NMR spectroscopy. According to the 13C-labelling pattern indicated by the 13C-NMR spectra, the biosynthesis of all plastidic isoprenoids investigated (prenyl side-chains of chlorophylls and plastoquinone-9, and the carotenoids β-carotene and lutein), as well as of the non-plastidic cytoplasmic sterols, does not proceed via the classical acetate/mevalonate pathway (which leads from acetyl-CoA via mevalonate to isopentenyl diphosphate), but via the novel glyceraldehyde 3-phosphate/pyruvate route recently detected in eubacteria. Formation of isopentenyl diphosphate involves the condensation of a C2 unit derived from pyruvate decarboxylation with glyceraldehyde 3-phosphate and a transposition yielding the branched C5 skeleton of isoprenic units.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1042/bj3160073

Cites

25 of 25 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Algal Physiology and Biochemistry.
Baalen, C. V., & Stewart, W. P. D. (1975) · Bulletin of the Torrey Botanical Club · doi:10.2307/2484419 · Cited by 1,453
Isoprenoid biosynthesis in bacteria: a novel pathway for the early steps leading to isopentenyl diphosphate
Rohmer, M., Knani, M., Simonin, P., Sutter, B., & Sahm, H. (1993) · Biochemical Journal · doi:10.1042/bj2950517 · Cited by 1,200
Self-citation
The Biochemistry of the Carotenoids
Goodwin, T. W. (1984) · Springer eBooks · doi:10.1007/978-94-009-5542-4 · Cited by 1,010
Terpenoid Metabolism
McGarvey, D. J., & Croteau, R. (1995) · The Plant Cell · doi:10.1105/tpc.7.7.1015 · Cited by 722
The Biochemistry of the Carotenoids
Goodwin, T. W. (1980) · Springer eBooks · doi:10.1007/978-94-009-5860-9 · Cited by 613
Biosynthesis of isoprenoid compounds
(1982) · Comparative Biochemistry and Physiology Part A Physiology · doi:10.1016/0300-9629(82)90284-5 · Cited by 557
Carbon-13nmr spectroscopy
Moore, G. R. (1989) · Spectrochimica Acta Part A Molecular Spectroscopy · doi:10.1016/0584-8539(89)80139-4 · Cited by 401
Biosynthesis of isoprenoid compounds
(1982) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(82)90032-5 · Cited by 372
Some new aspects of isoprenoid biosynthesis in plants—A review
Bach, T. J. (1995) · Lipids · doi:10.1007/bf02537822 · Cited by 301
Prokaryotic hopanoids: the biosynthesis of the bacteriohopane skeleton: Formation of isoprenic units from two distinct acetate pools and a novel type of carbon/carbon linkage between a triterpene and d‐ribose
FLESCH, G., & ROHMER, M. (1988) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1988.tb14210.x · Cited by 233
Self-citation

Flagged first, then by citations

Show all 25 references

Research works printed but not linked: 10

Goodwin, T. W. (1977) in Lipid and Lipid Polymers of Higher Plants (Tevini, M. and Lichtenthaler, H. K., eds.), pp. 29-47, Springer Verlag, Berlin
Lichtenthaler, H. K. (1977) in Lipid and Lipid Polymers of Higher Plants (Tevini, M. and Lichtenthaler, H. K., eds.), pp. 231-258, Springer Verlag, Berlin
Bach, T. J. and Lichtenthaler, H. K. (1982) in Biochemistry and Metabolism of Plant Lipids (Wintermanns, J. F. G. M. and Kuiper, P. J. C., eds.), pp. 515-521, Elsevier Biochemical Press, Amsterdam 16
ll, M., Schindler, S., Lichtenthaler, H. K. and Bach, T. J. (1984) in Structure, Function and Metabolism of Plant Lipids (Siegenthaler, P. A. and Eichenberger, W., eds.), pp. 277-280, Elsevier Science Publishers, Amsterdam Received 16 November 1995/10 January 1996 ; accepted 15 January 1996
Rohmer, M., Seemann, M. Horbach, S., Bringer-Meyer, S. and Sahm, H. (1996) J. Am. Chem. Soc., in the press 21
Breitmeier, E. and Voelter, W. (1990) Carbon-13 NMR Spectroscopy, pp. 335 and 444, VCH Verlagsgesellschaft mbH, Weinheim, Germany 25
Seo, S., Uomori, A., Yoshimura, Y., Takeda, K., Seto, H., Ebizuka, Y., Noguchi, H. and Sankawa, U. (1989) J. Chem. Soc. Perkin Trans. 1 1969-1974
Broers, S. T. J. (1994) Ph.D. Thesis, Eidgeno$ ssische Technische Hochschule, Zu$ rich, Switzerland 37
Eichenberger, W. (1977) in Lipid and Lipid Polymers of Higher Plants (Tevini, M. and Lichtenthaler, H. K., eds.), pp. 169-179, Springer Verlag, Berlin 43
Schwarz, M. K. (1994) Ph.D. Thesis, Eidgeno$ ssische Technische Hochschule, Zu$ rich, Switzerland 51

Sorted by citations

Second Generation Biofuels: High-Efficiency Microalgae for Biodiesel Production
Schenk, P. M., Thomas‐Hall, S. R., Stephens, E., Marx, U. C., Mussgnug, J. H., Posten, C. H., Kruse, O., & Hankamer, B. D. (2008) · BioEnergy Research · doi:10.1007/s12155-008-9008-8 · Cited by 2,335
Biogenic Volatile Organic Compounds (VOC): An Overview on Emission, Physiology and Ecology
KESSELMEIER, J., & Staudt, M. (1999) · Journal of Atmospheric Chemistry · doi:10.1023/a:1006127516791 · Cited by 1,879
The return of metabolism: biochemistry and physiology of the pentose phosphate pathway
Stincone, A., Prigione, A., Cramer, T., Wamelink, M. M. C., Campbell, K., Cheung, E., Olin‐Sandoval, V., Grüning, N., Krüger, A., Tauqeer Alam, M., et al. (2015) · Biological Reviews · doi:10.1111/brv.12140 · Cited by 1,576
THE 1-DEOXY-D-XYLULOSE-5-PHOSPHATE PATHWAY OF ISOPRENOID BIOSYNTHESIS IN PLANTS
Lichtenthaler, H. K. (1999) · Annual Review of Plant Physiology and Plant Molecular Biology · doi:10.1146/annurev.arplant.50.1.47 · Cited by 1,403
Self-citation
The discovery of a mevalonate-independent pathway for isoprenoid biosynthesis in bacteria, algae and higher plants†
Rohmer, M., & Rohmer, M. (1999) · Natural Product Reports · doi:10.1039/a709175c · Cited by 1,193
Self-citation
Molecular Paleohydrology: Interpreting the Hydrogen-Isotopic Composition of Lipid Biomarkers from Photosynthesizing Organisms
Sachse, D., Billault, I., Bowen, G. J., Chikaraishi, Y., Dawson, T. E., Feakins, S. J., Freeman, K. H., Magill, C. R., McInerney, F. A., van der Meer, M. T. J., et al. (2012) · Annual Review of Earth and Planetary Sciences · doi:10.1146/annurev-earth-042711-105535 · Cited by 1,021
GENES AND ENZYMES OF CAROTENOID BIOSYNTHESIS IN PLANTS
Cunningham, F. X., & Gantt, E. (1998) · Annual Review of Plant Physiology and Plant Molecular Biology · doi:10.1146/annurev.arplant.49.1.557 · Cited by 966
Isoprenoid biosynthesis: The evolution of two ancient and distinct pathways across genomes
Lange, B. M., Rujan, T., Martin, W., & Croteau, R. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.240454797 · Cited by 881
Botryococcus braunii: a rich source for hydrocarbons and related ether lipids
Metzger, P., & Largeau, C. (2005) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-004-1779-z · Cited by 735
Biosynthesis of isoprenoids in higher plant chloroplasts proceeds via a mevalonate‐independent pathway
Lichtenthaler, H. K., Schwender, J., Disch, A., & Rohmer, M. (1997) · FEBS Letters · doi:10.1016/s0014-5793(96)01404-4 · Cited by 711
Self-citation
1-Deoxy-d-xylulose-5-phosphate Synthase, a Limiting Enzyme for Plastidic Isoprenoid Biosynthesis in Plants
Estévez, J. M., Cantero, A., Reindl, A., Reichler, S. A., & León, P. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100854200 · Cited by 672
GIBBERELLIN BIOSYNTHESIS: Enzymes, Genes and Their Regulation
Hedden, P., & Kamiya, Y. (1997) · Annual Review of Plant Physiology and Plant Molecular Biology · doi:10.1146/annurev.arplant.48.1.431 · Cited by 637
Biosynthesis of Cholesterol and Other Sterols
Nes, W. D. (2011) · Chemical Reviews · doi:10.1021/cr200021m · Cited by 657
Metabolic maps and functions of the Plasmodium falciparum apicoplast
Ralph, S. A., van Dooren, G. G., Waller, R. F., Crawford, M. J., Fraunholz, M. J., Foth, B. J., Tonkin, C. J., Roos, D. S., & McFadden, G. I. (2004) · Nature Reviews Microbiology · doi:10.1038/nrmicro843 · Cited by 646
Fractionation of hydrogen isotopes in lipid biosynthesis
Sessions, A. L., Burgoyne, T. W., Schimmelmann, A., & Hayes, J. M. (1999) · Organic Geochemistry · doi:10.1016/s0146-6380(99)00094-7 · Cited by 598
Insect pheromones—an overview of biosynthesis and endocrine regulation
Tillman, J. A., Seybold, S. J., Jurenka, R. A., & Blomquist, G. J. (1999) · Insect Biochemistry and Molecular Biology · doi:10.1016/s0965-1748(99)00016-8 · Cited by 547
Cyclization Enzymes in the Biosynthesis of Monoterpenes, Sesquiterpenes, and Diterpenes
Davis, E. M., & Croteau, R. (2000) · Topics in current chemistry · doi:10.1007/3-540-48146-x_2 · Cited by 507
Two independent biochemical pathways for isopentenyl diphosphate and isoprenoid biosynthesis in higher plants
Lichtenthaler, H. K., Rohmer, M., & Schwender, J. (1997) · Physiologia Plantarum · doi:10.1111/j.1399-3054.1997.tb01049.x · Cited by 473
Self-citation
A 1-deoxy- d -xylulose 5-phosphate reductoisomerase catalyzing the formation of 2- C -methyl- d -erythritol 4-phosphate in an alternative nonmevalonate pathway for terpenoid biosynthesis
Takahashi, S., Kuzuyama, T., Watanabe, H., & Seto, H. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.17.9879 · Cited by 470
Identification of a thiamin-dependent synthase in Escherichia coli required for the formation of the 1-deoxy- d -xylulose 5-phosphate precursor to isoprenoids, thiamin, and pyridoxol
Sprenger, G. A., Schörken, U., Wiegert, T., Grolle, S., de Graaf, A. A., Taylor, S. V., Begley, T. P., Bringer‐Meyer, S., & Sahm, H. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.24.12857 · Cited by 468
Flux balance analysis of primary metabolism in Chlamydomonas reinhardtii
Boyle, N. R., & Morgan, J. A. (2009) · BMC Systems Biology · doi:10.1186/1752-0509-3-4 · Cited by 455
Cross-talk between the Cytosolic Mevalonate and the Plastidial Methylerythritol Phosphate Pathways in Tobacco Bright Yellow-2 Cells
Hemmerlin, A., Hoeffler, J., Meyer, O., Tritsch, D., Kagan, I. A., Grosdemange‐Billiard, C., Rohmer, M., & Bach, T. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302526200 · Cited by 442
Self-citation
The deoxyxylulose phosphate pathway of terpenoid biosynthesis in plants and microorganisms
Eisenreich, W., Schwarz, M. K., Cartayrade, A., Arigoni, D., Zenk, M. H., & Bacher, A. (1998) · Chemistry & Biology · doi:10.1016/s1074-5521(98)90002-3 · Cited by 437
Fosmidomycin, a specific inhibitor of 1-deoxy-d-xylulose 5-phosphate reductoisomerase in the nonmevalonate pathway for terpenoid biosynthesis
Kuzuyama, T., Shimizu, T., Takahashi, S., & Seto, H. (1998) · Tetrahedron Letters · doi:10.1016/s0040-4039(98)01755-9 · Cited by 383
Terpenoid biosynthesis from 1-deoxy- d -xylulose in higher plants by intramolecular skeletal rearrangement
Arigoni, D., Sagner, S., Latzel, C., Eisenreich, W., Bacher, A., & Zenk, M. H. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.20.10600 · Cited by 367
Chemistry of the Retinoid (Visual) Cycle
Kiser, P. D., Golczak, M., & Palczewski, K. (2014) · Chemical Reviews · doi:10.1021/cr400107q · Cited by 353
A family of transketolases that directs isoprenoid biosynthesis via a mevalonate-independent pathway
Lange, B. M., Wildung, M. R., McCaskill, D. G., & Croteau, R. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.5.2100 · Cited by 360
The biosynthesis of C5–C25 terpenoid compounds
Dewick, P. M. (2002) · Natural Product Reports · doi:10.1039/b002685i · Cited by 371
A raison d’être for two distinct pathways in the early steps of plant isoprenoid biosynthesis?
Hemmerlin, A., Harwood, J. L., & Bach, T. J. (2011) · Progress in Lipid Research · doi:10.1016/j.plipres.2011.12.001 · Cited by 371
Cloning and characterization of a gene from Escherichia coli encoding a transketolase-like enzyme that catalyzes the synthesis of d -1-deoxyxylulose 5-phosphate, a common precursor for isoprenoid, thiamin, and pyridoxol biosynthesis
Lois, L. M., Campos, N., Putra, S. R., Danielsen, K., Rohmer, M., & Boronat, A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.5.2105 · Cited by 354
Self-citation
Enzymatic Aspects of Isoprenoid Chain Elongation
Ogura, K., & Koyama, T. (1998) · Chemical Reviews · doi:10.1021/cr9600464 · Cited by 347
Molecular docking as a popular tool in drug design, an in silico travel
de Ruyck, J., Brysbaert, G., Blossey, R., & Lensink, M. F. (2016) · Advances and Applications in Bioinformatics and Chemistry · doi:10.2147/aabc.s105289 · Cited by 365
Mechanistic Aspects of Carotenoid Biosynthesis
Moise, A. R., Al‐Babili, S., & Wurtzel, E. T. (2013) · Chemical Reviews · doi:10.1021/cr400106y · Cited by 332
Methylerythritol 4-phosphate (MEP) pathway metabolic regulation
Banerjee, A., & Sharkey, T. D. (2014) · Natural Product Reports · doi:10.1039/c3np70124g · Cited by 313
Metabolic engineering of the nonmevalonate isopentenyl diphosphate synthesis pathway inEscherichia coli enhances lycopene production
Kim, S.-W., & Keasling, J. D. (2001) · Biotechnology and Bioengineering · doi:10.1002/1097-0290(20000220)72:4 · Cited by 300
Biosynthetic effects on the stable carbon isotopic compositions of algal lipids: implications for deciphering the carbon isotopic biomarker record
Stefan Schouten, A., Breteler, W. C. M. K., Blokker, P., Schogt, N., Rijpstra, W. I. C., Grice, K., Baas, M., & Damsté, J. S. S. (1998) · Geochimica et Cosmochimica Acta · doi:10.1016/s0016-7037(98)00076-3 · Cited by 298
Squalene – biochemistry, molecular biology, process biotechnology, and applications
Spanova, M., & Daum, G. (2011) · European Journal of Lipid Science and Technology · doi:10.1002/ejlt.201100203 · Cited by 268
Colorful World of Microbes: Carotenoids and Their Applications
Kirti, K., Saini, A., Priti, S., Kumar, A. M., & Jyoti, S. (2014) · Advances in Biology · doi:10.1155/2014/837891 · Cited by 268
Identification, Evolution, and Essentiality of the Mevalonate Pathway for Isopentenyl Diphosphate Biosynthesis in Gram-Positive Cocci
Wilding, E. I., Brown, J. R., Bryant, A. P., Chalker, A. F., Holmes, D. J., Ingraham, K. A., Iordănescu, S., So, C. Y., Rosenberg, M. J., & Gwynn, M. N. (2000) · Journal of Bacteriology · doi:10.1128/jb.182.15.4319-4327.2000 · Cited by 261
Five Geranylgeranyl Diphosphate Synthases Expressed in Different Organs Are Localized into Three Subcellular Compartments in Arabidopsis
Okada, K., Saito, T., Nakagawa, T., Kawamukai, M., & Kamiya, Y. (2000) · PLANT PHYSIOLOGY · doi:10.1104/pp.122.4.1045 · Cited by 258
The pathway of biosynthesis of abscisic acid in vascular plants: a review of the present state of knowledge of ABA biosynthesis
Milborrow, B. V. (2001) · Journal of Experimental Botany · doi:10.1093/jexbot/52.359.1145 · Cited by 254
Isoprenoid biosynthesis in eukaryotic phototrophs: A spotlight on algae
Lohr, M., Schwender, J., & Polle, J. E. W. (2011) · Plant Science · doi:10.1016/j.plantsci.2011.07.018 · Cited by 246
Self-citation
Isoprenoids: Remarkable diversity of form and function
Holstein, S. A., & Hohl, R. J. (2004) · Lipids · doi:10.1007/s11745-004-1233-3 · Cited by 249
The role of lateral gene transfer in the evolution of isoprenoid biosynthesis pathways
Boucher, Y., & Doolittle, W. F. (2000) · Molecular Microbiology · doi:10.1046/j.1365-2958.2000.02004.x · Cited by 252
Biosynthesis, accumulation and emission of carotenoids, α-tocopherol, plastoquinone, and isoprene in leaves under high photosynthetic irradiance
Lichtenthaler, H. K. (2007) · Photosynthesis Research · doi:10.1007/s11120-007-9204-y · Cited by 247
Self-citation
Analysis of the Expression of CLA1, a Gene That Encodes the 1-Deoxyxylulose 5-Phosphate Synthase of the 2-C-Methyl- d -Erythritol-4-Phosphate Pathway in Arabidopsis
Estévez, J. M., Cantero, A., Romero, C., Kawaide, H., Jiménez, L. F., Kuzuyama, T., Seto, H., Kamiya, Y., & León, P. (2000) · PLANT PHYSIOLOGY · doi:10.1104/pp.124.1.95 · Cited by 239
Biosynthesis and regulation of carotenoids in Dunaliella: Progresses and prospects
Ye, Z.-W., Jiang, J.-G., & Wu, G.-H. (2008) · Biotechnology Advances · doi:10.1016/j.biotechadv.2008.03.004 · Cited by 238
Two distantly related genes encoding 1‐deoxy‐ d ‐xylulose 5‐phosphate synthases: differential regulation in shoots and apocarotenoid‐accumulating mycorrhizal roots
Walter, M. H., Hans, J., & Strack, D. (2002) · The Plant Journal · doi:10.1046/j.1365-313x.2002.01352.x · Cited by 223
Distribution of the mevalonate and glyceraldehyde phosphate/pyruvate pathways for isoprenoid biosynthesis in unicellular algae and the cyanobacterium Synechocystis PCC 6714
Disch, A., Schwender, J., Müller, C. R., Lichtenthaler, H. K., & Rohmer, M. (1998) · Biochemical Journal · doi:10.1042/bj3330381 · Cited by 217
Self-citation
Expression of an exogenous isopentenyl diphosphate isomerase gene enhances isoprenoid biosynthesis in Escherichia coli
Kajiwara, S., Fraser, P. D., Kondô, K., & Misawa, N. (1997) · Biochemical Journal · doi:10.1042/bj3240421 · Cited by 210
The effects of varying CO2 concentration on lipid composition and carbon isotope fractionation in Emiliania huxleyi
Riebesell, U., Revill, A. T., Holdsworth, D. G., & Volkman, J. K. (2000) · Geochimica et Cosmochimica Acta · doi:10.1016/s0016-7037(00)00474-9 · Cited by 209
Metabolic engineering of carotenoid accumulation in Escherichia coli by modulation of the isoprenoid precursor pool with expression of deoxyxylulose phosphate synthase
Matthews, P. D., & Wurtzel, E. T. (2000) · Applied Microbiology and Biotechnology · doi:10.1007/s002530051632 · Cited by 203
Feedback Inhibition of Deoxy-d-xylulose-5-phosphate Synthase Regulates the Methylerythritol 4-Phosphate Pathway
Banerjee, A., Wu, Y., Banerjee, R., Li, Y., Honggao Yan, A., & Sharkey, T. D. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.464636 · Cited by 193
Incorporation of 1‐deoxy‐ d ‐xylulose into isoprene and phytol by higher plants and algae
Schwender, J., Zeidler, J. G., Gröner, R., Müller, C. R., Focke, M., Braun, S., Lichtenthaler, F. W., & Lichtenthaler, H. K. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)01002-8 · Cited by 180
Self-citation
Dedicated Roles of Plastid Transketolases during the Early Onset of Isoprenoid Biogenesis in Pepper Fruits1
Bouvier, F., d’Harlingue, A., Suire, C., Backhaus, R. A., & Camara, B. (1998) · PLANT PHYSIOLOGY · doi:10.1104/pp.117.4.1423 · Cited by 171
Isoprenoid Biosynthesis via a Mevalonate-Independent Pathway in Plants: Cloning and Heterologous Expression of 1-Deoxy-d-xylulose-5-phosphate Reductoisomerase from Peppermint
Lange, B. M., & Croteau, R. (1999) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1999.1168 · Cited by 163
Characterization of the Arabidopsis clb6 Mutant Illustrates the Importance of Posttranscriptional Regulation of the Methyl- d -Erythritol 4-Phosphate Pathway
Guevara‐García, A., Román, C. S., Arroyo-Becerra, A., Cortés, M. E., Gutiérrez-Nava, M. D. L. L., & León, P. (2005) · The Plant Cell · doi:10.1105/tpc.104.028860 · Cited by 165
Carbon isotopic fractionation associated with lipid biosynthesis by a cyanobacterium: Relevance for interpretation of biomarker records
Sakata, S., Hayes, J. M., McTaggart, A. R., Evans, R. A., Leckrone, K. J., & Togasaki, R. K. (1997) · Geochimica et Cosmochimica Acta · doi:10.1016/s0016-7037(97)00314-1 · Cited by 160
Expression of prokaryotic 1‐deoxy‐ d ‐xylulose‐5‐phosphatases in Escherichia coli increases carotenoid and ubiquinone biosynthesis
Harker, M., & Bramley, P. M. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)00360-9 · Cited by 152
Aquatic Plants Exposed to Pharmaceuticals: Effects and Risks
Brain, R. A., Hanson, M. L., Solomon, K. R., & Brooks, B. W. (2008) · Reviews of Environmental Contamination and Toxicology · doi:10.1007/978-0-387-71724-1_3 · Cited by 153
Towards efficient terpenoid biosynthesis: manipulating IPP and DMAPP supply
Wang, Q., Quan, S., & Xiao, H. (2019) · Bioresources and Bioprocessing · doi:10.1186/s40643-019-0242-z · Cited by 158
Molecular Biosignatures
Summons, R. E., Albrecht, P., McDonald, G. D., & Moldowan, J. M. (2007) · Space Science Reviews · doi:10.1007/s11214-007-9256-5 · Cited by 155
Direct formation of 2-C-methyl-d-erythritol 4-phosphate from 1-deoxy-d-xylulose 5-phosphate by 1-deoxy-d-xylulose 5-phosphate reductoisomerase, a new enzyme in the non-mevalonate pathway to isopentenyl diphosphate
Kuzuyama, T., Takahashi, S., Watanabe, H., & Seto, H. (1998) · Tetrahedron Letters · doi:10.1016/s0040-4039(98)00802-8 · Cited by 147
Terpenoids from Marine Organisms: Unique Structures and their Pharmacological Potential
Gross, H., & König, G. M. (2006) · Phytochemistry Reviews · doi:10.1007/s11101-005-5464-3 · Cited by 147
BIOSYNTHESIS OF CONIFEROPHAGOUS BARK BEETLE PHEROMONES AND CONIFER ISOPRENOIDS: EVOLUTIONARY PERSPECTIVE AND SYNTHESIS
Seybold, S. J., Bohlmann, J., & Raffa, K. F. (2000) · The Canadian Entomologist · doi:10.4039/ent132697-6 · Cited by 145
Biosynthesis of the gibberellin plant hormones
MacMillan, J. (1997) · Natural Product Reports · doi:10.1039/np9971400221 · Cited by 141
Arabidopsis Genes Essential for Seedling Viability: Isolation of Insertional Mutants and Molecular Cloning
Budziszewski, G. J., Lewis, S. P., Glover, L. W., Reineke, J., Jones, G., Ziemnik, L. S., Lonowski, J., Nyfeler, B., Aux, G., Zhou, Q., et al. (2001) · Genetics · doi:10.1093/genetics/159.4.1765 · Cited by 141
Phototrophic production of heterologous diterpenoids and a hydroxy-functionalized derivative from Chlamydomonas reinhardtii
Lauersen, K. J., Wichmann, J., Baier, T., Kampranis, S. C., Pateraki, I., Møller, B. L., & Kruse, O. (2018) · Metabolic Engineering · doi:10.1016/j.ymben.2018.07.005 · Cited by 124
Sterol methyl transferase: enzymology and inhibition
Nes, W. R. (2000) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s1388-1981(00)00138-4 · Cited by 139
Mevalonate-derived isopentenyl diphosphate is the biosynthetic precursor of ubiquinone prenyl side chain in tobacco BY-2 cells
Disch, A., Hemmerlin, A., Bach, T. J., & Rohmer, M. (1998) · Biochemical Journal · doi:10.1042/bj3310615 · Cited by 134
Self-citation
Biosynthesis of the isoprene units of chamomile sesquiterpenes
Adam, K., & Zapp, J. (1998) · Phytochemistry · doi:10.1016/s0031-9422(97)00992-8 · Cited by 134
A Mevalonate-independent Route to Isopentenyl Diphosphate
Rohmer, M. (1999) · Elsevier eBooks · doi:10.1016/b978-0-08-091283-7.00036-9 · Cited by 133
Self-citation
Chlorophyta exclusively use the 1-deoxyxylulose 5-phosphate/2-C-methylerythritol 4-phosphate pathway for the biosynthesis of isoprenoids
Schwender, J., Gemünden, C., & Lichtenthaler, H. (2001) · Planta · doi:10.1007/s004250000409 · Cited by 137
Self-citation
Identification and Functional Analysis of Light-Responsive Unique Genes and Gene Family Members in Rice
Jung, K., Lee, J., Dardick, C. D., Seo, Y.-S., Cao, P., Canlas, P. E., Phetsom, J., Xu, X., Ouyang, S., An, K., et al. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000164 · Cited by 127
Simultaneous operation of the mevalonate and non-mevalonate pathways in the biosynthesis of isopentenly diphosphate in Streptomyces aeriouvifer
Seto, H., Watanabe, H., & Furihata, K. (1996) · Tetrahedron Letters · doi:10.1016/0040-4039(96)01787-x · Cited by 127
Isoprenoid biosynthesis in the diatoms Rhizosolenia setigera (Brightwell) and Haslea ostrearia (Simonsen)
Massé, G., Belt, S. T., Rowland, S. J., & Rohmer, M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400902101 · Cited by 127
Self-citation
Carbon isotope variability in monosaccharides and lipids of aquatic algae and terrestrial plants
van Dongen, B. E., Stefan Schouten, A., & Damsté, J. S. S. (2002) · Marine Ecology Progress Series · doi:10.3354/meps232083 · Cited by 125
Natural Abundance Carbon Isotope Composition of Isoprene Reflects Incomplete Coupling between Isoprene Synthesis and Photosynthetic Carbon Flow
Affek, H. P., & Yakir, D. (2003) · PLANT PHYSIOLOGY · doi:10.1104/pp.102.012294 · Cited by 123
Microbial production of isoprenoids
Chandran, S. S., Kealey, J. T., & Reeves, C. D. (2011) · Process Biochemistry · doi:10.1016/j.procbio.2011.05.012 · Cited by 121
Light-dependent regulation of carotenoid biosynthesis in plants
Stange, C., & Pizarro, L. (2009) · International Journal of Agriculture and Natural Resources · doi:10.4067/s0718-16202009000200001 · Cited by 122
Biochemistry and physiology of foliar isoprene production
Logan, B. A., Monson, R. K., & Potosnak, M. J. (2000) · Trends in Plant Science · doi:10.1016/s1360-1385(00)01765-9 · Cited by 111
The unicellular green alga Dunaliella salina Teod. as a model for abiotic stress tolerance: genetic advances and future perspectives
Ramos, A., Polle, J. E. W., Tran, D., Cushman, J. C., Jin, E., & Varela, J. C. S. (2011) · ALGAE · doi:10.4490/algae.2011.26.1.003 · Cited by 116
Molecular biology of gibberellin synthesis
Lange, T. (1998) · Planta · doi:10.1007/s004250050274 · Cited by 110
Some caveats for bioengineering terpenoid metabolism in plants
McCaskill, D. G., & Croteau, R. (1998) · Trends in biotechnology · doi:10.1016/s0167-7799(98)01231-1 · Cited by 110
The LS locus of pea encodes the gibberellin biosynthesis enzyme ent‐kaurene synthase A
Aït-Ali, T., Swain, S. M., Reid, J. B., Sun, T., & Kamiya, Y. (1997) · The Plant Journal · doi:10.1046/j.1365-313x.1997.11030443.x · Cited by 109
Only a Subset of Phosphoantigen-Responsive γ9δ2 T Cells Mediate Protective Tuberculosis Immunity
Spencer, C. T., Abate, G., Blazevic, A., & Hoft, D. F. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.7.4471 · Cited by 105
Thiamin-dependent enzymes as catalysts in chemoenzymatic syntheses
Schörken, U., & Sprenger, G. A. (1998) · Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology · doi:10.1016/s0167-4838(98)00071-5 · Cited by 105
Isoprenoid biosynthesis via 1-deoxy-D-xylulose 5-phosphate/2-C-methyl-D-erythritol 4-phosphate (DOXP/MEP) pathway.
Wanke, M., Skorupinska-Tudek, K., & Świeżewska, E. (2001) · Acta Biochimica Polonica · doi:10.18388/abp.2001_3901 · Cited by 103
Inverse relationship between D/H fractionation in cyanobacterial lipids and salinity in Christmas Island saline ponds
Sachse, D., & Sachs, J. P. (2007) · Geochimica et Cosmochimica Acta · doi:10.1016/j.gca.2007.11.022 · Cited by 102
Genetics of Capsular Polysaccharides and Cell Envelope (Glyco)lipids
Daffé, M., Crick, D. C., & Jackson, M. (2014) · Microbiology Spectrum · doi:10.1128/microbiolspec.mgm2-0021-2013 · Cited by 105
Eukaryotic microalgae as hosts for light-driven heterologous isoprenoid production
Lauersen, K. J. (2018) · Planta · doi:10.1007/s00425-018-3048-x · Cited by 100
From Molecular Fossils of Bacterial Hopanoids to the Formation of Isoprene Units: Discovery and Elucidation of the Methylerythritol Phosphate Pathway
Rohmer, M. (2008) · Lipids · doi:10.1007/s11745-008-3261-7 · Cited by 95
Self-citation
Biosynthesis of Organic Compounds Emitted by Plants
Kreuzwieser, J., Schnitzler, J., & Steinbrecher, R. (1999) · Plant Biology · doi:10.1055/s-2007-978501 · Cited by 97
Crystal Structure of Mycobacterium tuberculosis MenB, a Key Enzyme in Vitamin K2 Biosynthesis
Truglio, J. J., Theis, K. W., Feng, Y., Gajda, R., Machutta, C. A., Tonge, P. J., & Kisker, C. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m307399200 · Cited by 95
Hydrogen isotope fractionation in lipids of the methane-oxidizing bacterium Methylococcus capsulatus
Sessions, A. L., Jahnke, L. L., Schimmelmann, A., & Hayes, J. M. (2002) · Geochimica et Cosmochimica Acta · doi:10.1016/s0016-7037(02)00981-x · Cited by 94
Differential effects of nutrient limitations on biochemical constituents and docosahexaenoic acid production of Schizochytrium sp.
Sun, L., Ren, L., Zhuang, X., Ji, X., Yan, J., & Huang, H. (2014) · Bioresource Technology · doi:10.1016/j.biortech.2014.02.106 · Cited by 91
Isoprenoid biosynthesis in higher plants and in Escherichia coli: on the branching in the methylerythritol phosphate pathway and the independent biosynthesis of isopentenyl diphosphate and dimethylallyl diphosphate
Hoeffler, J., Hemmerlin, A., Grosdemange‐Billiard, C., Bach, T. J., & Rohmer, M. (2002) · Biochemical Journal · doi:10.1042/bj20020337 · Cited by 91
Self-citation
Biosynthesis of marine natural products: microorganisms and macroalgae
Moore, B. S. (1999) · Natural Product Reports · doi:10.1039/a805873c · Cited by 93
Sterols of freshwater microalgae: potential implications for zooplankton nutrition
Martin‐Creuzburg, D., & Merkel, P. (2016) · Journal of Plankton Research · doi:10.1093/plankt/fbw034 · Cited by 92
Incorporation of 1-[1-13C]Deoxy-d-xylulose in Chamomile Sesquiterpenes
Adam, K., Thiel, R., & Zapp, J. (1999) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1999.1346 · Cited by 91

Authors: SCHWENDER, J., SEEMANN, M., LICHTENTHALER, H. K., & ROHMER, M.
Affiliations: Karlsruhe Institute of Technology (DE)
École nationale supérieure de chimie de Mulhouse (FR)
Centre National de la Recherche Scientifique (FR)
ORCID: SCHWENDER, Jörg
SEEMANN, Myriam
ROHMER, Michel
Venue: Biochemical Journal
Publisher: Portland Press Ltd.
Published: 1996-05-15
Volume: 316
Issue: 1
Pages: 73-80
ISSN: 0264-6021 (ISSN-L)
1470-8728
DOI: 10.1042/bj3160073
PMC: PMC1217352
OpenAlex: W1924177464
Cited by: 370
References: 25
Citations by year: 2026: 3 · 2025: 3 · 2024: 5 · 2023: 6 · 2022: 8 · 2021: 7 · 2020: 7 · 2019: 7 · 2018: 8 · 2017: 9 · 2016: 6 · 2015: 8 · 2014: 10 · 2013: 11 · 2012: 12
FWCI: 11.99
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Biochemical Journal (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Centre National de la Recherche Scientifique
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant biochemistry and biosynthesis
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Photosynthetic Processes and Mechanisms
Keywords: isoprenoid biosynthesis, methylerythritol phosphate pathway, Scenedesmus obliquus, carotenoids, sterols, plastoquinone-9, beta-carotene, lutein, isopentenyl pyrophosphate, 13C labeling, green algae
MeSH terms: Chlorophyta, Carbon Isotopes, Carotenoids, Chlorophyll, Glyceraldehyde 3-Phosphate, Glyoxylates, Magnetic Resonance Spectroscopy, Pentose Phosphate Pathway, Plastoquinone, Pyruvates, Sterols, Terpenes

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Biosynthesis of isoprenoids (carotenoids, sterols, prenyl side-chains of chlorophylls and plastoquinone) via a novel pyruvate/glyceraldehyde 3-phosphate non-mevalonate pathway in the green alga Scenedesmus obliquus

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks