The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Biosynthesis of isoprenoids (carotenoids, sterols, prenyl side-chains of chlorophylls and plastoquinone) via a novel pyruvate/glyceraldehyde 3-phosphate non-mevalonate pathway in the green alga Scenedesmus obliquus
Open accessAbstract
Isoprenoid biosynthesis was investigated in the green alga Scenedesmus obliquus grown heterotrophically on 13C-labelled glucose and acetate. Several isoprenoid compounds were isolated and investigated by 13C-NMR spectroscopy. According to the 13C-labelling pattern indicated by the 13C-NMR spectra, the biosynthesis of all plastidic isoprenoids investigated (prenyl side-chains of chlorophylls and plastoquinone-9, and the carotenoids β-carotene and lutein), as well as of the non-plastidic cytoplasmic sterols, does not proceed via the classical acetate/mevalonate pathway (which leads from acetyl-CoA via mevalonate to isopentenyl diphosphate), but via the novel glyceraldehyde 3-phosphate/pyruvate route recently detected in eubacteria. Formation of isopentenyl diphosphate involves the condensation of a C2 unit derived from pyruvate decarboxylation with glyceraldehyde 3-phosphate and a transposition yielding the branched C5 skeleton of isoprenic units.
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“Research in eubacteria and plants then revealed a second metabolic route for IPP synthesis referred to as the methylerythritol 4-phosphate (MEP) or nonmevalonate pathway, which utilizes the triose derivative, d-glyceraldehyde 3-phosphate along with pyruvate as starting materials90−94”
From Chemistry of the Retinoid (Visual) Cycle (2014) · cites this paper as [92]
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The return of metabolism: biochemistry and physiology of the pentose phosphate pathway
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Metadata
- Authors
- SCHWENDER, J., SEEMANN, M., LICHTENTHALER, H. K., & ROHMER, M.
- Affiliations
- Karlsruhe Institute of Technology (DE)
- École nationale supérieure de chimie de Mulhouse (FR)
- Centre National de la Recherche Scientifique (FR)
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 1996-05-15
- Volume
- 316
- Issue
- 1
- Pages
- 73-80
- ISSN
- 0264-6021 (ISSN-L)
- 1470-8728
- PMC
- PMC1217352
- OpenAlex
- W1924177464
- Cited by
- 370
- References
- 25
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 5 · 2023: 6 · 2022: 8 · 2021: 7 · 2020: 7 · 2019: 7 · 2018: 8 · 2017: 9 · 2016: 6 · 2015: 8 · 2014: 10 · 2013: 11 · 2012: 12
- FWCI
- 11.99
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Biochemical Journal (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Centre National de la Recherche Scientifique
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant biochemistry and biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Photosynthetic Processes and Mechanisms
- Keywords
- isoprenoid biosynthesis, methylerythritol phosphate pathway, Scenedesmus obliquus, carotenoids, sterols, plastoquinone-9, beta-carotene, lutein, isopentenyl pyrophosphate, 13C labeling, green algae
- MeSH terms
- Chlorophyta, Carbon Isotopes, Carotenoids, Chlorophyll, Glyceraldehyde 3-Phosphate, Glyoxylates, Magnetic Resonance Spectroscopy, Pentose Phosphate Pathway, Plastoquinone, Pyruvates, Sterols, Terpenes
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