Cited by 118Selenium in Biological SystemsWound Healing and TreatmentsRedox biology and oxidative stress

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A novel type of glutathione peroxidase: expression and regulation during wound repair

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MUNZ, Barbara, FRANK, Stefan, HÜBNER, Griseldis, OLSEN, Eydfinnur, WERNER, Sabine·1997·Biochemical Journal

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Abstract

We have previously identified and cloned a novel keratinocyte growth factor (KGF)-regulated gene in human keratinocytes that encodes the human homologue of a bovine non-selenium glutathione peroxidase (GPx). To gain insight into the regulation of this gene in vivo, we isolated the murine homologue from a mouse skin cDNA library. In vitro transcription/translation demonstrated that the cDNA encodes a 27 kDa protein. Furthermore, we amplified by PCR a partial cDNA that most likely corresponds to a related gene. RNase protection analysis revealed tissue-specific expression of both genes and the occurrence of alternative splicing or RNA editing of at least one of the primary transcripts. Similar to that of KGF, expression of GPx was strongly induced after cutaneous injury, and each isoform displayed unique kinetics of expression during the repair process. In situ hybridization studies demonstrated high levels of GPx mRNA in keratinocytes of the hyperproliferative epithelium at the wound edge. Since these cells express functional KGF receptors, induction of GPx expression by KGF might also occur in vivo. These data suggest a role for GPx in the protection of epithelial cells against oxidative stress, particularly during the inflammatory phase of wound repair.

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Authors: MUNZ, B., FRANK, S., HÜBNER, G., OLSEN, E., & WERNER, S.
Affiliations: Max Planck Institute of Biochemistry (DE)
Danish Centre for Human Genome Research, Ole Worms Alle 170, DK-8000 Aarhus C, Denmark
Corresponding author: MUNZ, Barbara
FRANK, Stefan
WERNER, Sabine
ORCID: WERNER, Sabine
Venue: Biochemical Journal
Publisher: Portland Press Ltd.
Published: 1997-09-01
Volume: 326
Issue: 2
Pages: 579-585
ISSN: 0264-6021 (ISSN-L)
1470-8728
DOI: 10.1042/bj3260579
PMC: PMC1218708
OpenAlex: W2267571706
Cited by: 118
References: 32
Citations by year: 2026: 1 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 4 · 2018: 2 · 2017: 1 · 2016: 2 · 2015: 1 · 2014: 5 · 2013: 4 · 2012: 1
FWCI: 10.59
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Biochemical Journal (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Eli Lilly and Company
Verband der Chemischen Industrie
Deutsche Forschungsgemeinschaft
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Selenium in Biological Systems
Health Sciences › Medicine › Surgery › Wound Healing and Treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords: glutathione peroxidase, keratinocyte growth factor, keratinocytes, wound healing, skin wounds, gene expression regulation, alternative splicing, RNA editing, tissue-specific gene expression, oxidative stress, inflammatory phase, mouse skin
MeSH terms: Amino Acid Sequence, Animals, Base Sequence, Cattle, Cell Division, Cloning, Molecular, Epithelial Cells, Epithelium, Female, Gene Expression Regulation, Multigene Family, Glutathione Peroxidase, Humans, Mice, Inbred BALB C, Molecular Sequence Data, Molecular Weight, Organ Specificity, Wound Healing, Keratinocytes, Mice

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A novel type of glutathione peroxidase: expression and regulation during wound repair

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