Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling

Cited by (953)

Items 501–600 of 953

1. Natural Protection from Apoptosis by Surfactant Protein A in Type II Pneumocytes
   Martyn K. White, Vijayabhasker Baireddy, David S. Strayer · 2001 · Experimental Cell Research
2. Srcasm Corrects Fyn-induced Epidermal Hyperplasia by Kinase Down-regulation
   Weijie Li, Christine M. Marshall, Lijuan Mei, Joel M. Gelfand, John T. Seykora · 2006 · Journal of Biological Chemistry
3. Normalization of Prandial Blood Glucose and Improvement of Glucose Tolerance by Liver-Specific Inhibition of SH2 Domain–Containing Inositol Phosphatase 2 (SHIP2) in Diabetic KKAy Mice
   Rolf Grempler, Darya Zibrova, Corinna Schoelch, André van Marle, Joerg F. Rippmann, Norbert H. Redemann · 2007 · Diabetes
4. Novel functions of thyroid hormone receptor mutants: Beyond nucleus-initiated transcription
   Fumihiko Furuya, Hao Ying, Li Zhao, Sheue-yann Cheng · 2006 · Steroids
5. The dwarf mutation decreases high dose insulin responses in skeletal muscle, the opposite of effects in liver
   Fernando Pablo Dominici, Danila P. Argentino, Andrzej Bartke, Daniel Turyn · 2003 · Mechanisms of Ageing and Development
6. The mechanistic and ergogenic effects of phosphatidic acid in skeletal muscle
   Brandon J. Shad, Benoit Smeuninx, Philip James Atherton, Leigh Breen · 2015 · Applied Physiology, Nutrition, and Metabolism
7. Distinct Regulation of IRS Proteins in Adipose Tissue from Obese Aged and Dexamethasone-Treated Rats
   Luciana Chagas Caperuto, Gabriel Forato Anhê, Angélica M. Amanso, Luciene Maria Ribeiro, Mayrin Correa Medina, Lilian C. Souza, Olga Carvalho, Silvana Auxiliadora Bordin, Mário J.A. Saad, Carla Roberta de Oliveira Carvalho · 2006 · Endocrine
8. Knockdown of insulin receptor substrate 1 reduces proliferation and downregulates Akt/mTOR and MAPK pathways in K562 cells
   João Agostinho Machado‐Neto, Patricia M.B. Favaro, Mariana Lazarini, Fernando Ferreira Costa, Sara Teresinha Olalla Saad, Fabı́ola Traina · 2011 · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
9. Novel roles for insulin receptor (IR) in adipocytes and skeletal muscle cells via new and unexpected substrates
   Latha Ramalingam, Eunjin Oh, Debbie C. Thurmond · 2012 · Cellular and Molecular Life Sciences
10. Galangin Induces p53-independent S-phase Arrest and Apoptosis in Human Nasopharyngeal Carcinoma Cells Through Inhibiting PI3K−AKT Signaling Pathway
    Chuan‐Chun Lee, Meng‐Liang Lin, Menghsiao Meng, Shih‐Shun Chen · 2018 · Anticancer Research
11. δ‐Opioid receptors stimulate GLUT1‐mediated glucose uptake through Src‐ and IGF‐1 receptor‐dependent activation of PI3‐kinase signalling in CHO cells
    Maria C. Olianas, Simona Dedoni, Pierluigi Onali · 2011 · British Journal of Pharmacology
12. Adipose tissue compensates for defect of phosphatidylinositol 3′-kinase induced in liver and muscle by dietary fish oil in fed rats
    Charlotte Corporeau, Christelle Le Foll, Mohammed Taouis, Jean‐Paul Gouygou, J. P. Bergé, Jacques Delarue · 2005 · American Journal of Physiology-Endocrinology and Metabolism
13. Partial purification and characterization of a wortmannin-sensitive and insulin-stimulated protein kinase that activates heart 6-phosphofructo-2-kinase
    Johan Deprez, Luc Bertrand, Dario R. Alessi, U. Krause, Louis Hue, Mark H. Rider · 2000 · Biochemical Journal
14. Structure and function of phosphatidylinositol-3,4 kinase
    Makoto Funaki, Hideki Katagiri, Kouichi Inukai, Masotoshi Kikuchi, Tomoichiro Asano · 2000 · Cellular Signalling
15. Netrin 1 mediates protective effects exerted by insulin-like growth factor 1 on cochlear hair cells
    Kohei Yamahara, Takayuki Nakagawa, Juichi Ito, Kazuo Kinoshita, Koichi Omori, Norio Yamamoto · 2017 · Neuropharmacology
16. The non-saponin fraction of Korean Red Ginseng (KGC05P0) decreases glucose uptake and transport in vitro and modulates glucose production via down-regulation of the PI3K/AKT pathway in vivo
    Soo‐Jeung Park, Dasom Lee, Dakyung Kim, Minhee Lee, Gyo In, Sung-Tai Han, Sung Won Kim, Mi Hyang Lee, Ok‐Kyung Kim, Jeongmin Lee · 2019 · Journal of Ginseng Research
17. The skeletal muscle-specific glycogen-targeted protein phosphatase 1 plays a major role in the regulation of glycogen metabolism by adrenaline in vivo
    Barry J. Toole, Patricia T.W. Cohen · 2006 · Cellular Signalling
18. A Proanthocyanidin From Cinnamomum Zeylanicum Stimulates Phosphorylation Of Insulin Receptor In 3T3–L1 Adipocytes
    Muhammad Taher, Fadzilah Adibah Abdul Majid, Mohamad Roji Sarmidi · 2012 · Jurnal Teknologi
19. Novel vitamin K-dependent pathways regulating cell survival
    Satya P. Saxena, Esther D. Israels, Lyonel G. Israels · 2001 · APOPTOSIS
20. In Vitro Phosphorylation of Insulin Receptor Substrate 1 by Protein Kinase C-ζ: Functional Analysis and Identification of Novel Phosphorylation Sites
    Mark R. Sommerfeld, Sabine U Metzger, Magdalene Stosik, Norbert Tennagels, Jürgen Eckel · 2004 · Biochemistry
21. Survival Signaling in Type II Pneumocytes Activated by Surfactant Protein-A
    M WHITE, D S Strayer · 2002 · Experimental Cell Research
22. Expression of a Prenylation-Deficient Rab4 Interferes with Propagation of Insulin Signaling through Insulin Receptor Substrate-1
    John B. Knight, Kim T. Cao, George V. Gibson, Ann Louise Olson · 2000 · Endocrinology
23. E5 Oncoprotein Mutants Activate Phosphoinositide 3-Kinase Independently of Platelet-derived Growth Factor Receptor Activation
    Frank A. Suprynowicz, Jason Sparkowski, Astrid C. Baege, Richard Schlegel · 2000 · Journal of Biological Chemistry
24. Current targeted therapies in lymphomas
    Clement Chung · 2019 · American Journal of Health-System Pharmacy
25. Na+/Mg2+ exchange is functionally coupled to the insulin receptor
    Ana Catharyna Estrela Ferreira, Alicia Rivera, José R. Romero · 2003 · Journal of Cellular Physiology
26. Are transforming properties of the bovine papillomavirus E5 protein shared by E5 from high-risk human papillomavirus type 16?
    Frank A. Suprynowicz, Gary L. Disbrow, Vera Simić, Richard Schlegel · 2004 · Virology
27. Structural Studies of the Detergent-solubilized and Vesicle-reconstituted Insulin Receptor
    Christine N. Woldin, Frederick S. Hing, Jongsoon Lee, Paul F. Pilch, G. Graham Shipley · 1999 · Journal of Biological Chemistry
28. Exercise Training Eliminates Age-Related Differences in Skeletal Muscle Insulin Receptor and IRS-1 Abundance in Rats
    Edward B. Arias, Luc E. Gosselin, Gregory D. Cartee · 2001 · The Journals of Gerontology Series A
29. A Phosphatidylinositol 3-Kinase/p70 Ribosomal S6 Protein Kinase Pathway Is Required for the Regulation by Insulin of the p85α Regulatory Subunit of Phosphatidylinositol 3-Kinase Gene Expression in Human Muscle Cells
    Marina Roques, Hubert Vidal · 1999 · Journal of Biological Chemistry
30. Modulation of insulin effects on phosphorylation of protein kinase B and glycogen synthesis by tumor necrosis factor-α in HepG2 cells
    Dhananjay Gupta, Ramji L. Khandelwal · 2004 · Biochimica et Biophysica Acta (BBA) - General Subjects
31. Secreção da insulina: efeito autócrino da insulina e modulação por ácidos graxos
    Esther Piltcher Haber, Rui Curi, Carla Roberta de Oliveira Carvalho, Ângelo Rafael Carpinelli · 2001 · Arquivos Brasileiros de Endocrinologia & Metabologia
32. Genetic and Physiological Effects of Insulin-Like Growth Factor-1 (IGF-1) on Human Urate Homeostasis
    Asim K. Mandal, Megan Leask, Nicholas A. Sumpter, Hyon K. Choi, Tony Raymond Merriman, David Bruce Mount · 2023 · Journal of the American Society of Nephrology
33. Different Concentrations of Glucose Regulate Proliferation and Osteogenic Differentiation of Osteoblasts Via the PI3 Kinase/Akt Pathway
    Zhonghao Liu, Huanhuan Jiang, Kai Dong, Shutai Liu, Wenjuan Zhou, Jing Zhang, Lei Meng, Xiaohui Rausch‐Fan, Xin Wen Xu · 2015 · Implant Dentistry
34. Bilobalide regulates soluble amyloid precursor protein release via phosphatidyl inositol 3 kinase-dependent pathway
    Chun Shi, Fengming Wu, Jie Xu, Juntao Zou · 2011 · Neurochemistry International
35. Bisindolylmaleimides in anti-cancer therapy - more than PKC inhibitors
    Beata Pająk, S Orzechowska, B Gajkowska, A Orzechowski · 2008 · Advances in Medical Sciences
36. Insulin and exercise differentially regulate PI3-kinase and glycogen synthase in human skeletal muscle
    Donal J. O’Gorman, Luis F. Del Aguila, David L. Williamson, Raj K. Krishnan, John P. Kirwan · 2000 · Journal of Applied Physiology
37. Induction of EGFR-Dependent and EGFR-Independent Signaling Pathways by Ultraviolet A Irradiation
    Yiguo Zhang, Ziming Dong, Ann M. Bode, Weiya Ma, Nanyue Chen, Zigang Dong · 2001 · DNA and Cell Biology
38. Insulin Receptor Substrate 4 Supports Insulin- and Interleukin 4-Stimulated Proliferation of Hematopoietic Cells
    Valeria R. Fantin, Susanna R. Keller, Gustav E. Lienhard, Ling-Mei Wang · 1999 · Biochemical and Biophysical Research Communications
39. Expression of KCa channels in identified populations of developing vertebrate neurons: role of neurotrophic factors and activity
    Stuart E. Dryer · 2003 · Journal of Physiology-Paris
40. Dissociation between Insulin-Mediated Signaling Pathways and Biological Effects in Placental Cells: Role of Protein Kinase B and MAPK Phosphorylation
    Pascal Boileau, Michèle Caüzac, Marie Pereira, Jean R Girard, Sylvie Hauguel‐de Mouzon · 2001 · Endocrinology
41. Structural Perturbations due to Mutation (H1047R) in Phosphoinositide-3-kinase (PI3Kα) and Its Involvement in Oncogenesis: An in Silico Insight
    Jatin Sharma, Vijay Kumar Bhardwaj, Rituraj Purohit · 2019 · ACS Omega
42. Combination treatment of copanlisib and gemcitabine in relapsed/refractory PTCL (COSMOS): an open-label phase I/II trial
    Ho‐Young Yhim, T. Kim, Seung Ju Kim, Ho‐Jin Shin, Youngil Koh, Jin Sung Kim, Jinny Park, G.S. Park, Woo Seob Kim, Joon Ho Moon et al. · 2020 · Annals of Oncology
43. Zanthoxylum alkylamides ameliorate protein metabolism in type 2 diabetes mellitus rats by regulating multiple signaling pathways
    Xunyu Wei, Bing Yang, Xuhui Chen, Leyan Wen, Jianquan Kan · 2021 · Food & Function
44. Cyclooxygenase‐2 over‐expression inhibits liver apoptosis induced by hyperglycemia
    Daniel E. Francés, Paola I. Ingaramo, Rafael Mayoral, Paqui G. Través, Marta Casado, Ángela M. Valverde, Paloma Martín‐Sanz, Cristina Ester Carnovale · 2012 · Journal of Cellular Biochemistry
45. Heart 6-phosphofructo-2-kinase activation by insulin requires PKB (protein kinase B), but not SGK3 (serum- and glucocorticoid-induced protein kinase 3)
    Véronique Mouton, Louise Toussaint, Didier Vertommen, Marie-Agnès Gueuning, Liliane Maisin, Xavier Havaux, Cossette Sanchez Canedo, Luc Bertrand, Franck Dequiedt, Brian A. Hemmings et al. · 2010 · Biochemical Journal
46. Design, synthesis and biological evaluation of novel thieno[3,2-d]pyrimidine and quinazoline derivatives as potent antitumor agents
    Hao Hu, Yuhong Dong, Ming Li, Ruxin Wang, Xian Zhang, Ping Gong, Yanfang Zhao · 2019 · Bioorganic Chemistry
47. Hypoglycemic and insulin mimetic impact of catechin isolated from Cassia fistula: a substantiate in silico approach through docking analysis
    Pitchai Daisy, Manikkam Rajalakshmi · 2011 · Medicinal Chemistry Research
48. Reciprocal feedback regulation of insulin receptor and insulin receptor substrate tyrosine phosphorylation by phosphoinositide 3-kinase in primary adipocytes
    Ingeborg Hers, Christopher J. BELL, Alastair W. Poole, Donyang JIANG, Richard M. Denton, Erik Schaefer, Jeremy M. Tavaré · 2002 · Biochemical Journal
49. Insulin and insulin antagonists evoke phosphorylation of P20 at serine 157 and serine 16 respectively in rat skeletal muscle
    Yu Wang, Aimin Xu, Richard B. Pearson, Garth J. S. Cooper · 1999 · FEBS Letters
50. The Insulin Receptor Substrate (IRS)-1 Pleckstrin Homology Domain Functions in Downstream Signaling
    Inna Vainshtein, Kristina S. Kovacina, Richard A. Roth · 2001 · Journal of Biological Chemistry
51. Key Role of Cytochrome C for Apoptosis Detection Using Raman Microimaging in an Animal Model of Brain Ischemia with Insulin Treatment
    Vanessa Russo, Patrizio Candeloro, Natalia Malara, Gerardo Perozziello, Michelangelo Iannone, Miriam Scicchitano, Rocco Mollace, Vincenzo Musolino, Micaela Gliozzi, Cristina Carresi et al. · 2019 · Applied Spectroscopy
52. Phase I trial of copanlisib, a selective PI3K inhibitor, in combination with cetuximab in patients with recurrent and/or metastatic head and neck squamous cell carcinoma
    Grégoire Marret, Nicolás Isambert, Keyvan Rezaï, Jocelyn Gal, Esma Saâda-Bouzid, Frédéric Rolland, Maggy Chausson, Édith Borcoman, Marie Alt, Jerzy Klijanienko et al. · 2021 · Investigational New Drugs
53. PI3K regulates BMAL1/CLOCK-mediated circadian transcription from the Dbp promoter
    Yoshikazu Morishita, Daiki Miura, S. Kida · 2016 · Bioscience, biotechnology and biochemistry
54. Long-term denervation impairs insulin receptor substrate-1-mediated insulin signaling in skeletal muscle
    Munetaka Hirose, Masao Kaneki, Hiroki Sugita, Shingo Yasuhara, J. A. J. Martyn, Chikwendu Iebunjo · 2001 · Metabolism
55. Insulin receptor and insulin receptor substrate‐1 in rat retinae
    AD Gosbell, Ian Favilla, K. Baxter, Paula Jablonski · 2000 · Clinical and Experimental Ophthalmology
56. The relation among NGF, EGF and insulin is important for triggering pancreatic β cell apoptosis
    Selda Gezginci-Oktayoğlu, A. Karatug, Sema Bolkent · 2012 · Diabetes/Metabolism Research and Reviews
57. The diabetogenic effects of excessive ethanol: reducing β-cell mass, decreasing phosphatidylinositol 3-kinase activity and GLUT-4 expression in rats
    Lina Zhao, Liping Hao, Xuefeng Yang, Chenjiang Ying, Yu Dong, Xiufa Sun · 2008 · British Journal Of Nutrition
58. In vitro models of insulin resistance: Mitochondrial coupling is differently affected in liver and muscle cells
    Nina Krako Jakovljevic, Kasja Pavlović, Tijana Zujovic, Tamara Kravic‐Stevovic, Aleksandra Jotić, Ivanka Marković, Nebojsa M. Lalic · 2021 · Mitochondrion
59. Positive association of free triiodothyronine with pancreatic β‐cell function in people with prediabetes
    Tomoyasu Oda, Haruhito Taneichi, Kazuhiro Takahashi, Hirobumi Togashi, Mari Hangai, Riyuki Nakagawa, Mikiko Ono, Mizue Matsui, Takayoshi Sasai, Kan Nagasawa et al. · 2014 · Diabetic Medicine
60. Effect of progesterone and its synthetic analogs on reproduction and embryonic development of a freshwater invertebrate model
    Zita Zrínyi, Gábor Maász, Linwen Zhang, Ákos Vértes, Sándor Lovas, Tibor Kiss, Károly Elekes, Zsolt Pirger · 2017 · Aquatic Toxicology
61. Comparison of Gene Expression in Intra‐Abdominal and Subcutaneous Fat: A Study of Men with Morbid Obesity and Nonobese Men Using Microarray and Proteomics
    ABDOMINAL OBESITY STUDY GROUP, Finn Edler von Eyben, Jens Peter Kroustrup, Jens Fromholt Larsen, Julio E. Celis · 2004 · Annals of the New York Academy of Sciences
62. Potential Role of Growth Hormone in Impairment of Insulin Signaling in Skeletal Muscle, Adipose Tissue, and Liver of Rats Chronically Treated with Arginine
    Thaís de Castro Barbosa, José Edgar Nicoletti Carvalho, L. L. Poyares, Silvana Auxiliadora Bordin, Ubiratan Fabres Machado, Maria Tereza Nunes · 2008 · Endocrinology
63. Mechanisms involved in the nutritional regulation of mRNA translation: features of the avian model
    Sophie Tesseraud, Mourad Abbas, Sophie Duchêne, Karine Bigot, Pascal Vaudin, Joëlle Dupont · 2006 · Nutrition Research Reviews
64. Vanadium and the cardiovascular functions
    Lise Coderre, Ashok K. Srivastava · 2004 · Canadian Journal of Physiology and Pharmacology
65. Selective insulin-induced activation of class IA phosphoinositide 3-kinase in PIKfyve immune complexes from 3T3-L1 adipocytes
    Diego Sbrissa, Ognian Christov Ikonomov, Assia Shisheva · 2001 · Molecular and Cellular Endocrinology
66. Prospects for the treatment of endocrine-responsive tumours.
    Stephen Green, B.J.A. Furr · 1999 · Endocrine Related Cancer
67. The α‐isoform of class II phosphoinositide 3‐kinase is more effectively activated by insulin receptors than IGF receptors, and activation requires receptor NPEY motifs
    Birgitte Ursø, Richard A. Brown, Stephen O’Rahilly, Peter Robin Shepherd, Kenneth Siddle · 1999 · FEBS Letters
68. Phosphatidylinositol 3-Kinase Isoform-Specific Effects in Airway Mesenchymal Cell Function
    Lyn Margaret Moir, Thomas Trian, Qi Ge, Peter Robin Shepherd, Janette Kay Burgess, Brian Gregory George Oliver, Judith Lee Black · 2011 · Journal of Pharmacology and Experimental Therapeutics
69. β‐Adrenoceptor stimulation potentiates insulin‐stimulated PKB phosphorylation in rat cardiomyocytes via cAMP and PKA
    Jorid T. Stuenæs, Astrid Bolling, Ada Ingvaldsen, Camilla Rommundstad, Emina M. Sudar-Milovanovic, F.‐C. Lin, Yu‐Chiang Lai, Jørgen Jensen · 2010 · British Journal of Pharmacology
70. Mesenchymal stem cells suppress lung inflammation and airway remodeling in chronic asthma rat model via PI3K/Akt signaling pathway.
    Haiyan Lin, Lei Xu, Shuanshuan Xie, Fei Yu, Hai-Yang Hu, Xiaolian Song, Changhui Wang · 2015 · PubMed Central
71. Insulin Resistance: Concepts, Controversies, and the Role of Nutrition
    John L. Sievenpiper, Alexandra L. Jenkins, Dana Whitham, Vladimir V.V. Vuksan · 2002 · Canadian Journal of Dietetic Practice and Research
72. The Lnk/SH2B adaptor provides a fail-safe mechanism to establish the Insulin receptor-Chico interaction
    Isabel Almudí, Ingrid Poernbacher, Ernst Hafen, Hugo Stocker · 2013 · Cell Communication and Signaling
73. Regulation of insulin signal transduction pathway by a small-molecule insulin receptor activator
    Victor D. H. Ding, Sajjad A. Qureshi, Deborah Szalkowski, Zhihua Li, Dawn E. Biazzo-Ashnault, Dan Xie, Kun Liu, A. Brian Jones, David E. Moller, Bei B. Zhang · 2002 · Biochemical Journal
74. Pre- and early postnatal nongenetic determinants of type 2 diabetes
    Susan Elizabeth Ozanne, C. Nick Hales · 2002 · Expert Reviews in Molecular Medicine
75. Multiple Signaling Pathways Mediate Interleukin-4-Induced 3 -Hydroxysteroid Dehydrogenase/ 5- 4 Isomerase Type 1 Gene Expression in Human Breast Cancer Cells
    Sébastien Gingras, Stéphanie Côté, Jacques Simard · 2000 · Molecular Endocrinology
76. Association Analysis Indicates That a Variant GATA-Binding Site in the PIK3CB Promoter Is a Cis-Acting Expression Quantitative Trait Locus for This Gene and Attenuates Insulin Resistance in Obese Children
    Catherine Le Stunff, Agnès Dechartres, Virginie Mariot, Chantal Lotton, Cecelia D. Trainor, Emanuele Miraglia del Giudice, David Meyre, Ivan Bièche, Ingrid Laurendeau, Philippe Froguel et al. · 2007 · Diabetes
77. Molecular mechanisms of contraction-regulated cardiac glucose transport
    Martin Till, D. Margriet Ouwens, Alexandra Kessler, Jürgen Eckel · 2000 · Biochemical Journal
78. In Vitro and In Vivo Studies of a Naturally Occurring Variant of the Human p85α Regulatory Subunit of the Phosphoinositide 3-Kinase
    Lars Bolvig Hansen, Björn Zethelius, Lars Berglund, Richard Reneland, Torben F. Hansen, Christian Berne, Hans Lithell, Brian A. Hemmings, Oluf Borbye Pedersen · 2001 · Diabetes
79. TNF-α induces protein synthesis through PI3-kinase-Akt/PKB pathway in cardiac myocytes
    Eiji Hiraoka, Seinosuke Kawashima, Tomosaburo Takahashi, Yoshiyuki Rikitake, Tadahiro Kitamura, Wataru Ogawa, Mitsuhiro Yokoyama · 2001 · American Journal of Physiology-Heart and Circulatory Physiology
80. Extended treatment with selective phosphatidylinositol 3‐kinase and mTOR inhibitors has effects on metabolism, growth, behaviour and bone strength
    Greg C. Smith, W. Ong, J. L. Costa, M. Watson, J. Cornish, A. Grey, G. Gamble, M. Dickinson, Sophie Leung, G. Rewcastle et al. · 2013 · The FEBS Journal
81. Establishment of phosphatidylinositol 3‐kinase inhibitor‐resistant cancer cell lines and therapeutic strategies for overcoming the resistance
    Sho Isoyama, Shingo Dan, Yumiko H. Nishimura, Naoki Nakamura, Gensei Kajiwara, Mariko Seki, Tatsuro Irimura, Takao Yamori · 2012 · Cancer Science
82. Impairment of insulin receptor substrate 1 signaling by insulin resistance inhibits neurite outgrowth and aggravates neuronal cell death
    Juhyun Song, S-M Kang, Eosu Kim, Chul Hoon Kim, Ho‐Taek Song, Jong Eun Lee · 2015 · Neuroscience
83. Gαq Binds Two Effectors Separately in Cells: Evidence for Predetermined Signaling Pathways
    Urszula P. Golebiewska, Suzanne Scarlata · 2008 · Biophysical Journal
84. c-Src Activation by the E5 oncoprotein enables transformation independently of PDGF receptor activation
    Frank A. Suprynowicz, Astrid C. Baege, Iruvanti Sunitha, Richard Schlegel · 2002 · Oncogene
85. Coordinate activation of intracellular signaling pathways by insulin-like growth factor-1 and platelet-derived growth factor in rat hepatic stellate cells
    Kim R. Bridle, Lin Li, Rosemary O’Neill, Robert S. Britton, Bruce R. Bacon · 2006 · Journal of Laboratory and Clinical Medicine
86. Multiple signal transduction pathways mediate interleukin-4-induced 3β-hydroxysteroid dehydrogenase/Δ5–Δ4 isomerase in normal and tumoral target tissues
    Sébastien Gingras, Stéphanie Côté, Jacques Simard · 2001 · The Journal of Steroid Biochemistry and Molecular Biology
87. Expression of a prenylation-deficient Rab4 inhibits the GLUT4 translocation induced by active phosphatidylinositol 3-kinase and protein kinase B
    Mireille Cormont, Nadine Gautier, Karine Ilc, Yannick LE MARCHAND‐BRUSTEL · 2001 · Biochemical Journal
88. Astrocyte Resilience to Oxidative Stress Induced by Insulin-like Growth Factor I (IGF-I) Involves Preserved AKT (Protein Kinase B) Activity
    David Dávila, Silvia Fernández, Ignacio Torres‐Alemán · 2015 · Journal of Biological Chemistry · Retracted
89. Cudrania tricuspidatawater extract improved obesity-induced hepatic insulin resistance indb/dbmice by suppressing ER stress and inflammation
    Ok‐Kyung Kim, Da‐Eun Nam, Woojin Jun, Jeongmin Lee · 2015 · Food & Nutrition Research
90. Modulation of insulin signalling by insulin sensitizers
    Guoqiang Jiang, B.B. Zhang · 2005 · Biochemical Society Transactions
91. Extrapancreatic roles of glimepiride on osteoblasts from rat manibular bone in vitro: Regulation of cytodifferentiation through PI3-kinases/Akt signalling pathway
    Pan Ma, Wei Xiong, Hongchen Liu, Junli Ma, Bin Gu, Xia Wu · 2010 · Archives of Oral Biology
92. Mitogenic and Metabolic Effects of Type I IGF Receptor Overexpression in Insulin Receptor-Deficient Hepatocytes
    Jane J. Kim, Byung‐Chul Park, Yoshiaki Kido, Domenico Accili · 2001 · Endocrinology
93. Enzyme activity effects of N-terminal His-tag attached to catalytic sub-unit of phosphoinositide-3-kinase
    James M. J. J. Dickson, Woo-Jeong Lee, Peter Robin Shepherd, Christina Maree Buchanan · 2013 · Bioscience Reports
94. p110α and p110β isoforms of PI3K signaling: are they two sides of the same coin?
    Paramjeet Singh, M. S. Dar, Mohd Jamal Dar · 2016 · FEBS Letters
95. Synthesis and biological evaluation of novel phosphatidylinositol 3-kinase inhibitors: Solubilized 4-substituted benzimidazole analogs of 2-(difluoromethyl)-1-[4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]-1H-benzimidazole (ZSTK474)
    Gordon W. Rewcastle, Swarna A. Gamage, Jack U. Flanagan, Jackie D. Kendall, William Alexander Denny, Bruce C. Baguley, Christina Maree Buchanan, Mindy Chao, Philip Kestell, Sharada Kolekar et al. · 2013 · European Journal of Medicinal Chemistry
96. Hydrogen Peroxide-Induced Activation of SAPK/JNK Regulated by Phosphatidylinositol 3-Kinase in Chinese Hamster V79 Cells
    Osamu Inanami, Kenji Takahashi, Asuka Yoshito, Mikinori Kuwabara · 1999 · Antioxidants and Redox Signaling
97. Phosphatidylinositol 3-kinase p85α regulatory subunit gene PIK3R1 haplotype is associated with body fat and serum leptin in a female twin population
    Yalda Jamshidi, Harold Snieder, X. Wang, M. J. Pavitt, Tim D. Spector, N. D. Carter, Sandra D. O’Dell · 2006 · Diabetologia
98. Phosphoinositide lipid second messengers: new paradigms for transepithelial signal transduction
    Bonnie L. Blazer‐Yost, Charity Nofziger · 2004 · Pflügers Archiv - European Journal of Physiology
99. Synthesis and biological evaluation of sulfonamide analogues of the phosphatidylinositol 3-kinase inhibitor ZSTK474
    Swarna A. Gamage, Anna C. Giddens, Kit Yee Tsang, Jack U. Flanagan, Jackie D. Kendall, Woo-Jeong Lee, Bruce C. Baguley, Christina Maree Buchanan, Stephen M. F. Jamieson, Peter Robin Shepherd et al. · 2017 · Bioorganic & Medicinal Chemistry
100. In vivo insulin signaling through PI3-kinase is impaired in skeletal muscle of adult rat offspring exposed to ethanol in utero.
     Li Chen, Xing-Hai Yao, B. L. Grégoire Nyomba · 2005 · Journal of applied physiology