Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling

Cited by (953)

Items 101–200 of 953

1. The Epithelial Na+ Channel: Cell Surface Insertion and Retrieval in Na+ Homeostasis and Hypertension
   Peter M. Snyder · 2002 · Endocrine Reviews
2. Increased p85/55/50 Expression and Decreased Phosphotidylinositol 3-Kinase Activity in Insulin-Resistant Human Skeletal Muscle
   Bandyopadhyay, Gautam K., Yu, Joseph G., Ofrecio, Jachelle, Olefsky, Jerold M. · 2005 · Diabetes
3. Phosphoinositides in membrane traffic
   Silvia Corvera, Antonello D’Arrigo, Harald Stenmark · 1999 · Current Opinion in Cell Biology
4. Reduced expression of the murine p85α subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes
   Mauvais-Jarvis, Franck, Ueki, Kohjiro, Fruman, David A., Hirshman, Michael F., Sakamoto, Kei, Goodyear, Laurie J., Iannacone, Matteo, Accili, Domenico, Cantley, Lewis C., Kahn, C. Ronald · 2002 · Journal of Clinical Investigation
5. Positive and Negative Roles of p85α and p85β Regulatory Subunits of Phosphoinositide 3-Kinase in Insulin Signaling
   Kohjiro Ueki, David A. Fruman, Claudine M. Yballe, Mathias Faßhauer, Johannes Christian Klein, Tomoichiro Asano, Lewis C. Cantley, C. Ronald Kahn · 2003 · Journal of Biological Chemistry · Retracted
6. Insulin-related peptides and their conserved signal transduction pathway
   Ilse Claeys, Gert Simonet, Jeroen Poels, Tom Van Loy, Linda Vercammen, Arnold DE LOOF, Jozef Vanden Broeck · 2002 · Peptides
7. SGK integrates insulin and mineralocorticoid regulation of epithelial sodium transport
   Jian Wang, Pascal Barbry, Anita C. Maiyar, David J. Rozansky, Aditi Bhargava, Meredith L.L. Leong, Gary L. Firestone, David Pearce · 2001 · American Journal of Physiology-Renal Physiology
8. Akt signaling in skeletal muscle: regulation by exercise and passive stretch
   Kei Sakamoto, William G. Aschenbach, Michael F. Hirshman, Laurie J. Goodyear · 2003 · American Journal of Physiology-Endocrinology and Metabolism
9. Modulation of Insulin Receptor Substrate-1 Tyrosine Phosphorylation by an Akt/Phosphatidylinositol 3-Kinase Pathway
   Jin‐Ping Li, Kathryn DeFea, Richard A. Roth · 1999 · Journal of Biological Chemistry
10. Scaffolding Protein Grb2-associated Binder 1 Sustains Epidermal Growth Factor-induced Mitogenic and Survival Signaling by Multiple Positive Feedback Loops
    Kiyatkin, Anatoly, Aksamitiene, Edita, Markevich, Nick I., Borisov, Nikolay M., Hoek, Jan B., Kholodenko, Boris N. · 2006 · Journal of Biological Chemistry
11. Regulation of sterol regulatory-element binding protein 1 gene expression in liver: role of insulin and protein kinase B/cAkt
    Mark M. Fleischmann, Patrick B. Iynedjian · 2000 · Biochemical Journal
12. The long-term consequences of intra-uterine protein malnutrition for glucose metabolism
    Susan Elizabeth Ozanne, Charles Nicholas Hales · 1999 · Proceedings of The Nutrition Society
13. Contraction Regulation of Akt in Rat Skeletal Muscle
    Kei Sakamoto, Michael F. Hirshman, William G. Aschenbach, Laurie J. Goodyear · 2002 · Journal of Biological Chemistry
14. A regulatory subunit of phosphoinositide 3-kinase increases the nuclear accumulation of X-box–binding protein-1 to modulate the unfolded protein response
    Jonathon N. Winnay, Jérémie Boucher, Marcelo A. Mori, Kohjiro Ueki, C. Ronald Kahn · 2010 · Nature Medicine
15. Phosphorylation of Insulin Receptor Substrate-1 (IRS-1) by Protein Kinase B Positively Regulates IRS-1 Function
    Keren Paz, Yanfang Liu, Hagai Shorer, Rina Hemi, Derek LeRoith, Michael Quan, Hannah Kanety, Rony Seger, Yehiel Zick · 1999 · Journal of Biological Chemistry
16. PPARγ and Atherosclerosis
    Willa A. Hsueh, Ronald E. Law · 2001 · Arteriosclerosis Thrombosis and Vascular Biology
17. PI3-kinase inhibition: a target for drug development?
    Robert C. Stein, Michael Derek Waterfield · 2000 · Molecular Medicine Today
18. Emerging Roles for MicroRNAs in Diabetic Microvascular Disease: Novel Targets for Therapy
    Yu Zhang, Xinghui Sun, Basak Icli, Mark W. Feinberg · 2017 · Endocrine Reviews
19. Insulin Receptor Substrate 3 Is Not Essential for Growth or Glucose Homeostasis
    Simon C.H. Liu, Qing Wang, Gustav E. Lienhard, Susanna R. Keller · 1999 · Journal of Biological Chemistry
20. Hypothalamic PI3K and MAPK differentially mediate regional sympathetic activation to insulin
    Kamal Rahmouni, Donald A. Morgan, Gina M. Morgan, Xuebo Liu, Curt D. Sigmund, Allyn L. Mark, William Geoffrey Haynes · 2004 · Journal of Clinical Investigation
21. Berberine stimulates glucose transport through a mechanism distinct from insulin
    Libin Zhou, Ying Yang, Xiao Wang, Shangquan Liu, Wenbin Shang, Guoyue Yuan, Fengying Li, Jinfeng Tang, Ming‐Dao Chen, Jialun Chen · 2007 · Metabolism
22. Caveolin 1-Mediated Regulation of Receptor Tyrosine Kinase-Associated Phosphatidylinositol 3-Kinase Activity by Ceramide
    Wayne Zundel, Lillian Marie Swiersz, Amato J. Giaccia · 2000 · Molecular and Cellular Biology
23. Regulation of glucose transport by hypoxia
    Jinzhong Zhang, Alireza Behrooz, Faramarz Ismail‐Beigi · 1999 · American Journal of Kidney Diseases
24. Phosphatidylinositol 3‐kinase inhibitors: promising drug candidates for cancer therapy
    Dexin Kong, Takao Yamori · 2008 · Cancer Science
25. Leptin inhibits epileptiform‐like activity in rat hippocampal neurones via PI 3‐kinase‐driven activation of BK channels
    Lynne J. Shanley, Dervla O’Malley, Andrew J. Irving, Michael L.J. Ashford, Jenni Harvey · 2002 · The Journal of Physiology
26. Metabolic programming in animals
    Susan Elizabeth Ozanne · 2001 · British Medical Bulletin
27. Caspase-3 activation induced by inhibition of mitochondrial complex I is facilitated by glycogen synthase kinase-3β and attenuated by lithium
    Taj D. King, Gautam N. Bijur, Richard Scott Jope · 2001 · Brain Research
28. PKCλ in liver mediates insulin-induced SREBP-1c expression and determines both hepatic lipid content and overall insulin sensitivity
    Michihiro Matsumoto, Wataru Ogawa, Kazunori Akimoto, Hiroshi Inoue, Kazuaki Miyake, Kensuke Furukawa, Yoshitake Hayashi, Haruhisa Iguchi, Yasushi Matsuki, Ryuji Hiramatsu et al. · 2003 · Journal of Clinical Investigation
29. Increased insulin sensitivity and upregulation of insulin receptor, insulin receptor substrate (IRS)-1 and IRS-2 in liver of Ames dwarf mice
    Fernando Pablo Dominici, Steven Hauck, DP Argentino, Andrzej Bartke, Daniel Turyn · 2002 · Journal of Endocrinology
30. Activation of the Mammalian Target of Rapamycin Pathway Acutely Inhibits Insulin Signaling to Akt and Glucose Transport in 3T3-L1 and Human Adipocytes
    Frédéric Tremblay, AnneMarie Gagnon, Alain Veilleux, Alexander Sorisky, André Marette · 2004 · Endocrinology
31. The Major Target of the Endogenously Generated Reactive Oxygen Species in Response to Insulin Stimulation Is Phosphatase and Tensin Homolog and Not Phosphoinositide-3 Kinase (PI-3 Kinase) in the PI-3 Kinase/Akt Pathway
    Ji Hae Seo, Younghee Ahn, Seung-Rock Lee, Chang‐Yeol Yeo, Kyu Chung Hur · 2004 · Molecular Biology of the Cell
32. Insulin regulates soluble amyloid precursor protein release via phosphatidyl inositol 3 kinase‐dependent pathway
    Daniela C. Solano, Marita Sironi, Claudia Bonfini, Sebastiano Bruno Solerte, Stefano M. Govoni, Marco Racchi · 2000 · The FASEB Journal
33. Genotype-specific responses in Atlantic salmon (Salmo salar) subject to dietary fish oil replacement by vegetable oil: a liver transcriptomic analysis
    Sofia Morais, Jarunan Pratoomyot, John Bernard Taggart, James E. Bron, D. R. Guy, John Gordon Bell, Douglas Redford Tocher · 2011 · BMC Genomics
34. Leptin and insulin stimulation of signalling pathways in arcuate nucleus neurones: PI3K dependent actin reorganization and KATPchannel activation
    Mirshamsi, Shirin, Laidlaw, Hilary A, Ning, Ke, Anderson, Erin, Burgess, Laura A, Gray, Alexander, Sutherland, Calum, Ashford, Michael LJ · 2004 · BMC Neuroscience
35. Eat to reproduce: a key role for the insulin signaling pathway in adult insects
    Badisco, Liesbeth, Van Wielendaele, Pieter, Vanden Broeck, Jozef · 2013 · Frontiers in Physiology
36. Membrane Estrogen Receptor-Dependent Extracellular Signal-Regulated Kinase Pathway Mediates Acute Activation of Endothelial Nitric Oxide Synthase by Estrogen in Uterine Artery Endothelial Cells
    Dong‐bao Chen, Ian M. Bird, Jing Juan Zheng, Ronald R. Magness · 2003 · Endocrinology
37. β-Arrestin1 Mediates Insulin-like Growth Factor 1 (IGF-1) Activation of Phosphatidylinositol 3-Kinase (PI3K) and Anti-apoptosis
    Thomas Joseph Povsic, Trudy A. Kohout, Robert J. Lefkowitz · 2003 · Journal of Biological Chemistry
38. Differential insulin-like growth factor I receptor signaling and function in estrogen receptor (ER)-positive MCF-7 and ER-negative MDA-MB-231 breast cancer cells.
    Monica Bartucci, Catia Morelli, Loredana Mauro, Sebastiano Andò, Ewa Surmacz · 2001 · PubMed
39. Randomized clinical trial to compare the effects of preoperative oral carbohydrate versus placebo on insulin resistance after colorectal surgery
    Z G Wang, Q Wang, Wei-Zhong Wang, Huanlong Qin · 2010 · British journal of surgery
40. Class I phosphatidylinositol 3-kinase inhibitors for cancer therapy
    Wennan Zhao, Yuling Qiu, Dexin Kong · 2016 · Acta Pharmaceutica Sinica B
41. Regulation of Glucose Transport and Glycogen Synthesis in L6 Muscle Cells during Oxidative Stress
    Anne S. Blair, Éric Hajduch, Gary J. Litherland, Harinder S. Hundal · 1999 · Journal of Biological Chemistry
42. A High Fructose Diet Affects the Early Steps of Insulin Action in Muscle and Liver of Rats
    Rosângela Maria Neves Bezerra, Mirian Ueno, Maria S. Silva, Débora Q. Tavares, Carla Roberta de Oliveira Carvalho, Mário J. A. Saad · 2000 · Journal of Nutrition
43. Fatty Acid-Induced Insulin Resistance: Decreased Muscle PI3K Activation But Unchanged Akt Phosphorylation
    Yolanta T. Kruszynska, Dorothy Sears Worrall, Jachelle M. Ofrecio, Juan P. Frías, Gina Macaraeg, Jerrold M. Olefsky · 2002 · The Journal of Clinical Endocrinology & Metabolism
44. The Role of Phosphoinositide 3-Kinase C2α in Insulin Signaling
    Marco Falasca, William E. Hughes, Veronica Dominguez, Gianluca Sala, Florentia Fostira, Michelle Q. Fang, Rosanna Cazzolli, Peter Robin Shepherd, David Ernest James, Tania Maffucci · 2007 · Journal of Biological Chemistry
45. ZSTK474 is an ATP‐competitive inhibitor of class I phosphatidylinositol 3 kinase isoforms
    Dexin Kong, Takao Yamori · 2007 · Cancer Science
46. Casein kinase 2 as a potentially important enzyme in the nervous system
    P. Blanquet · 2000 · Progress in Neurobiology
47. Insulin signaling in the transcriptional and posttranscriptional regulation of CYP2E1 expression
    Kimberley J. Woodcroft, Mikehl S. Hafner, RAYMOND F. NOVAK · 2002 · Hepatology
48. Defective Signaling Through Akt-2 and -3 But Not Akt-1 in Insulin-Resistant Human Skeletal Muscle
    Joseph T. Brozinick, Brian R. Roberts, G. Lynis Dohm · 2003 · Diabetes
49. A drug targeting only p110α can block phosphoinositide 3-kinase signalling and tumour growth in certain cell types
    Stephen M. F. Jamieson, Jack U. Flanagan, Sharada Kolekar, Christina Maree Buchanan, Jackie D. Kendall, Woo Jung Lee, Gordon W. Rewcastle, William Alexander Denny, Ripudaman Singh, James M. J. J. Dickson et al. · 2011 · Biochemical Journal
50. Molecular connexions between dementia and diabetes
    Adam R. Cole, Arlene J. Astell, Charlotte Green, Calum D. Sutherland · 2007 · Neuroscience & Biobehavioral Reviews
51. Glucagon-Like Peptide-1 Gene Therapy in Obese Diabetic Mice Results in Long-Term Cure of Diabetes by Improving Insulin Sensitivity and Reducing Hepatic Gluconeogenesis
    Lee, Young-Sun, Shin, Seungjin, Shigihara, Toshikatsu, Hahm, Eunsil, Liu, Meng-Ju, Han, Jaeseok, Yoon, Ji-Won, Jun, Hee-Sook · 2007 · Diabetes
52. Dominant Role of the p110β Isoform of PI3K over p110α in Energy Homeostasis Regulation by POMC and AgRP Neurons
    Hind Al‐Qassab, Mark A. Smith, Elaine E. Irvine, Julie Guillermet‐Guibert, Marc Claret, Agharul I. Choudhury, Colin Selman, Kaisa Piipari, Melanie Clements, Steven J. Lingard et al. · 2009 · Cell Metabolism
53. Direct Effects of Caffeine and Theophylline on p110δ and Other Phosphoinositide 3-Kinases
    Lazaros C. Foukas, Nathalie Danièle, Chariklia Ktori, Karen E. Anderson, Jørgen Jensen, Peter Robin Shepherd · 2002 · Journal of Biological Chemistry
54. Insulin induces phosphatidylinositol‐3‐phosphate formation through TC10 activation
    Tania Maffucci, Anna Brancaccio, Enza Piccolo, Robert C. Stein, Marco Falasca · 2003 · The EMBO Journal
55. A Genome Scan for Positive Selection in Thoroughbred Horses
    Jingjing Gu, Nick Orr, Stephen D. Park, Lisa Michelle Katz, Г. Е. Сулимова, David Evan MacHugh, Emmeline Wynne Hill · 2009 · PLoS ONE
56. Mitogenic and Antiapoptotic Actions of Hepatocyte Growth Factor Through ERK, STAT3, and Akt in Endothelial Cells
    Hironori Nakagami, Ryuichi Morishita, Kei Yamamoto, Yoshiaki Taniyama, Motokuni Aoki, Kunio Matsumoto, Toshikazu Nakamura, Yasufumi Kaneda, Masatsugu Horiuchi, Toshio Ogihara · 2001 · Hypertension
57. Hyperinsulinemia, glucose intolerance, and dyslipidemia induced by acute inhibition of phosphoinositide 3-kinase signaling in the liver
    Kazuaki Miyake, Wataru Ogawa, Michihiro Matsumoto, Takehiro Nakamura, Hiroshi Sakaue, Masato Kasuga · 2002 · Journal of Clinical Investigation
58. Molecular Basis of Signaling Specificity of Insulin and IGF Receptors: Neglected Corners and Recent Advances
    Kenneth Siddle · 2012 · Frontiers in Endocrinology
59. Resistin inhibits glucose uptake in L6 cells independently of changes in insulin signaling and GLUT4 translocation
    Byoung C. Moon, Jamie J. Kwan, Noreen Duddy, Gary Sweeney, Najma Begum · 2003 · American Journal of Physiology-Endocrinology and Metabolism
60. The alcohol-inducible form of cytochrome P450 (CYP2E1): Role in toxicology and regulation of expression
    RAYMOND F. NOVAK, Kimberley J. Woodcroft · 2000 · Archives of Pharmacal Research
61. Nonradioactive methods for the assay of phosphoinositide 3-kinases and phosphoinositide phosphatases and selective detection of signaling lipids in cell and tissue extracts
    Alexander Gray, Henric Olsson, Ian H. Batty, Larisa Priganica, C. Peter Downes · 2003 · Analytical Biochemistry
62. Positive and Negative Regulation of Phosphoinositide 3-Kinase-Dependent Signaling Pathways by Three Different Gene Products of the p85α Regulatory Subunit
    Ueki, Kohjiro, Algenstaedt, Petra, Mauvais-Jarvis, Franck, Kahn, C. Ronald · 2000 · Molecular and Cellular Biology
63. Decreased Akt kinase activity and insulin resistance in C57BL/KsJ-Leprdb/db mice
    Jianhua Shao, Hitoshi Yamashita, Liping Qiao, JE Friedman · 2000 · Journal of Endocrinology
64. The Role of Ca2+ in Insulin-stimulated Glucose Transport in 3T3-L1 Cells
    Jonathan P. Whitehead, Juan Carlos Molero, Sharon F. Clark, Sally Martin, G S Meneilly, David Ernest James · 2001 · Journal of Biological Chemistry
65. Perspectives in bioinorganic chemistry of some metal based therapeutic agents
    Saeed Ahmad, Anvarhusein Abdulkadir Isab, Sajid Ali, Abdul Rahman Al‐Arfaj · 2005 · Polyhedron
66. Activation of phosphatidylinositol 3-kinase signaling by a mutant thyroid hormone β receptor
    Fumihiko Furuya, John A. Hanover, Sheue-yann Cheng · 2006 · Proceedings of the National Academy of Sciences
67. Tannins present in Cichorium intybus enhance glucose uptake and inhibit adipogenesis in 3T3-L1 adipocytes through PTP1B inhibition
    Velumani Muthusamy, S. Anand, K.N. Sangeetha, S. Sujatha, Balakrishnan Arun, Baddireddi Subhadra Lakshmi · 2008 · Chemico-Biological Interactions
68. The protein kinase C inhibitors bisindolylmaleimide I (GF 109203x) and IX (Ro 31‐8220) are potent inhibitors of glycogen synthase kinase‐3 activity
    Ingeborg Hers, Jeremy M. Tavaré, Richard M. Denton · 1999 · FEBS Letters
69. Increased P85α Is a Potent Negative Regulator of Skeletal Muscle Insulin Signaling and Induces in Vivo Insulin Resistance Associated with Growth Hormone Excess
    Linda A. Barbour, Shaikh Mizanoor Rahman, Inga Gurevich, J. Wayne Leitner, Stephanie J. Fischer, Michael D. Roper, Trina A. Knotts, Y. Vo, Carrie E. McCurdy, Shoshana Yakar et al. · 2005 · Journal of Biological Chemistry
70. Growth factor receptors as therapeutic targets: strategies to inhibit the insulin-like growth factor I receptor
    Eva Surmacz · 2003 · Oncogene
71. Class I phosphoinositide 3-kinase (PI3K) regulatory subunits and their roles in signaling and disease
    Manoj K Rathinaswamy, John E. Burke · 2019 · Advances in Biological Regulation
72. Metformin Regulates Glucose Transporter 4 (GLUT4) Translocation through AMP-activated Protein Kinase (AMPK)-mediated Cbl/CAP Signaling in 3T3-L1 Preadipocyte Cells
    Jung Ok Lee, Soo Kyung Lee, Ji Hae Kim, Nami Kim, Ga Young You, Ji Wook Moon, Su Jin Kim, Sun Hwa Park, Hyeon Soo Kim · 2012 · Journal of Biological Chemistry
73. Sterol Regulatory Element-binding Protein-1 Is Regulated by Glucose at the Transcriptional Level
    Alyssa H. Hasty, Hitoshi Shimano, Naoya Yahagi, Michiyo Amemiya-Kudo, Stéphane Perrey, Tomohiro Yoshikawa, Jun-ichi Osuga, Hiroaki Okazaki, Yoshiaki Tamura, Yoko Iizuka et al. · 2000 · Journal of Biological Chemistry
74. Adipocytes from Munc18c-null mice show increased sensitivity to insulin-stimulated GLUT4 externalization
    Hajime Kanda, Yoshikazu Tamori, Hiroaki Shinoda, Mari Yoshikawa, Motoyoshi Sakaue, Jun Udagawa, Hiroki Otani, Fumi Tashiro, Jun‐ichi Miyazaki, Masato Kasuga · 2005 · Journal of Clinical Investigation
75. Essential Role of Phosphoinositide 3-Kinase in Leptin-inducedK ATP Channel Activation in the Rat CRI-G1 Insulinoma Cell Line
    Jenni Harvey, Neil G. McKay, Kay S. Walker, Jeroen VAN DER KAAY, C. Peter Downes, Michael L.J. Ashford · 2000 · Journal of Biological Chemistry
76. Lipid rafts and insulin signaling
    Perry E. Bickel · 2002 · American Journal of Physiology-Endocrinology and Metabolism
77. Insulin-mimetic and insulin-sensitizing activities of a pentacyclic triterpenoid insulin receptor activator
    Seung Ho Jung, Yun Jung Ha, Eun Kyung Shim, Soo Young Choi, Jingling Jin, Hye Sook Yun‐Choi, Jong Ran Lee · 2007 · Biochemical Journal
78. Evidence That 3-Phosphoinositide-dependent Protein Kinase-1 Mediates Phosphorylation of p70 S6 Kinase in Vivoat Thr-412 as well as Thr-252
    Anudharan Balendran, Richard A. Currie, Christopher G. Armstrong, Joseph Avruch, Dario R. Alessi · 1999 · Journal of Biological Chemistry
79. Engagement of the insulin-sensitive pathway in the stimulation of glucose transport by α-lipoic acid in 3T3-L1 adipocytes
    Karen Yaworsky, Romel Somwar, Toolsie Ramlal, Hans Tritschler, Amira Klip · 2000 · Diabetologia
80. Insulin Activates the α Isoform of Class II Phosphoinositide 3-Kinase
    Richard A. Brown, Jan Domin Y, Alexandre Arcaro, Michael Derek Waterfield, Peter Robin Shepherd · 1999 · Journal of Biological Chemistry
81. Liver-specific Protein-tyrosine Phosphatase 1B (PTP1B) Re-expression Alters Glucose Homeostasis of PTP1B–/–Mice
    Fawaz G. Haj, Janice M. Zabolotny, Young‐Bum Kim, Barbara B. Kahn, Benjamin G. Neel · 2005 · Journal of Biological Chemistry
82. Leptin in the CNS: much more than a satiety signal
    Jenni Harvey, Michael L.J. Ashford · 2003 · Neuropharmacology
83. Signalling through the insulin receptor
    Whitehead, Jonathan P, Clark, Sharon F, Ursø, Birgitte, James, David E · 2000 · Current Opinion in Cell Biology
84. Overview of Newer Agents: Where Treatment Is Going
    Ralph A. DeFronzo · 2010 · The American Journal of Medicine
85. Mechanisms regulating phosphoinositide 3‐kinase signalling in insulin‐sensitive tissues
    Peter Robin Shepherd · 2005 · Acta Physiologica Scandinavica
86. Characterisation of a plant 3‐phosphoinositide‐dependent protein kinase‐1 homologue which contains a pleckstrin homology domain
    Mária Deák, Antonio Casamayor, Richard A. Currie, C. Peter Downes, Dario R. Alessi · 1999 · FEBS Letters
87. Prospects for phosphoinositide 3-kinase inhibition as a cancer treatment.
    Robert C. Stein · 2001 · Endocrine Related Cancer
88. Insulin action and signalling in fat and muscle from dexamethasone-treated rats
    Burén, J., Lai, Y.C., Lundgren, M., Eriksson, J.W., Jensen, J. · 2008 · Archives of Biochemistry and Biophysics
89. Modulation of cellular apoptotic potential: contributions to oncogenesis
    Vuk Stambolic, Tak W. Mak, James Robert Woodgett · 1999 · Oncogene
90. Insulin/IGF-1 and ROS signaling pathway cross-talk in aging and longevity determination
    John Papaconstantinou · 2008 · Molecular and Cellular Endocrinology
91. Berberine Moderates Glucose and Lipid Metabolism through Multipathway Mechanism
    Qian Zhang, Xinhua Xiao, Kai Feng, Tong Wang, Wenhui Li, Tao Yuan, Xiaofang Sun, Qi Sun, Hongding Xiang, Heng Wang · 2010 · Evidence-based Complementary and Alternative Medicine
92. Phosphoinositide-Regulated Kinases and Phosphoinositide Phosphatases
    Nicholas R. Leslie, Ricardo M. Biondi, Dario R. Alessi · 2001 · Chemical Reviews
93. Intracellular Mechanisms Involved in Leptin Regulation of Sympathetic Outflow
    Rahmouni, Kamal, Haynes, William G., Morgan, Donald A., Mark, Allyn L. · 2003 · Hypertension
94. Regulation of rat Sertoli cell function by FSH: possible role of phosphatidylinositol 3-kinase/protein kinase B pathway
    Silvina Beatriz Meroni, María Fernanda Riera, Eliana Herminia Pellizzari, S.B. Cigorraga · 2002 · Journal of Endocrinology
95. Subcellular Compartmentalization and Trafficking of the Insulin-Responsive Glucose Transporter, GLUT4
    Robert Tony Watson, Jeffrey E. Pessin · 2001 · Experimental Cell Research
96. Akt2 Is Essential for the Full Effect of Calorie Restriction on Insulin-Stimulated Glucose Uptake in Skeletal Muscle
    Carrie E. McCurdy, Gregory D. Cartee · 2005 · Diabetes
97. Free fatty acid-induced muscle insulin resistance and glucose uptake dysfunction: Evidence for PKC activation and oxidative stress-activated signaling pathways
    Rafik Ragheb, Gamila M.L. Shanab, Amina M. Medhat, Dina M. Seoudi, Khosrow Adeli, I. George Fantus · 2009 · Biochemical and Biophysical Research Communications
98. Peroxisome proliferator-activated receptor gamma as a drug target in the pathogenesis of insulin resistance
    Liang Guo, Reza Tabrizchi · 2005 · Pharmacology & Therapeutics
99. Discovery and Optimization of a Series of Benzothiazole Phosphoinositide 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Dual Inhibitors
    Noel D. D’Angelo, Tae‐Seong Kim, Kristin L. Andrews, Shon K. Booker, Sean R. Caenepeel, Kui Chen, Derin C. D’Amico, Dan Freeman, Jian Wei Jiang, Longbin Liu et al. · 2011 · Journal of Medicinal Chemistry
100. Structural Basis for Recruitment of the Adaptor Protein APS to the Activated Insulin Receptor
     Junjie Hu, Jun Liu, Rodolfo Ghirlando, Alan R. Saltiel, Stevan R. Hubbard · 2003 · Molecular Cell